A5032433044- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Glioma Diagnosis and Treatment
- Computational Drug Discovery Methods
- Bioinformatics and Genomic Networks
- Metabolomics and Mass Spectrometry Studies
- Trigeminal Neuralgia and Treatments
- Cytokine Signaling Pathways and Interactions
- Facial Nerve Paralysis Treatment and Research
- MicroRNA in disease regulation
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Functional Brain Connectivity Studies
- Melanoma and MAPK Pathways
- Sphingolipid Metabolism and Signaling
- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- Cancer Mechanisms and Therapy
- Cerebral Venous Sinus Thrombosis
- Immunotherapy and Immune Responses
- Advanced Neuroimaging Techniques and Applications
Hebei Medical University
2021-2025
Second Hospital of Hebei Medical University
2021-2025
Sphingosine kinase 1 (SPHK1) is a member of the SPHK family, enzymes essential for phosphorylation sphingosine to sphingosine-1-phosphate (S1P). Previous studies have revealed important roles SPHK1 in inflammatory, anti-apoptotic, immune processes, and cancer. Although predictive significance possible gliomas recently been examined, precise molecular mechanisms remain unclear. We comprehensively examined investigated its correlation with glioma survival time using different datasets. The...
Arylsulfatase D (ARSD) belongs to the sulfatase family and plays a crucial role in maintaining proper structure of bone cartilage matrix. Although several researches have revealed functions ARSD tumor progression, prognostic value glioma related mechanisms not been fully investigated.We performed pan-cancer analysis ARSD, investigated relationship between expression overall survival (OS) multiple datasets. ROC curves nomograms were created investigate predictive capacity ARSD. Immune...
Glioma is a common type of brain tumor with high incidence and mortality rates. Procollagen C-protease enhancer protein (PCOLCE) has been shown to regulate growth metastasis in several cancers. However, the role PCOLCE glioma unknown. This study aims assess association between prognosis glioma, investigated potential mechanisms.The prognostic value was determined using data from nine publicly available cohorts. We also relationship immune microenvironment predicted response immunotherapy...
Glioma, the most frequent and malignant central nervous system (CNS) cancer, has a bad outcome. Proteasome 26S subunit ATPase 2 (PSMC2) is an essential part of proteasome promotes development several tumors. However, pathway function PSMC2 in glioma have not been unelucidated. This study analyzed expression tissues its predictive significance for patients. We examined link between DNA methylation, immune cell infiltration, tumor cycle, homeostasis, checkpoints. Subsequently,...
STEAP3 is a metal reductase located on the plasma membrane close to nucleus and vesicles. Despite numerous studies indicating involvement of in tumor advancement, prognostic value glioma related mechanisms have not been fully investigated.Initially, we examined correlation between expression survival rate various datasets. To assess capability for one-year, three-year, five-year survival, created receiver operating characteristic (ROC) curves nomograms. Additionally, an investigation was...
ACSS3 (acyl-CoA synthetase short-chain family member 3) is found in numerous tissues and linked to tumor cell type development metastasis.
<title>Abstract</title> Background Glioma exhibits a high recurrence rate and unfavorable prognosis, with the mechanisms underlying regulation of glioma cell proliferation, invasion, migration remaining elusive. CAMK2B, crucial kinase involved in regulating growth synaptic plasticity, remains enigmatic terms its specific role glioma. Methods This study comprehensively analyzed correlation between expression level CAMK2B gliomas patient prognosis using immunohistochemistry, qRT-PCR, Western...
Abstract Mapping the localization of functional brain regions in trigeminal neuralgia (TN) patients is still lacking. The study aimed to explore alterations and influencing factors TN using imaging techniques. All participants underwent collect resting-state activity. significant differences regional homogeneity (ReHo) amplitude low frequency (ALFF) between control groups were calculated. After familywise error (FWE) correction, differential ReHo values two mainly located bilateral middle...
Background: Spinal cord glioma (SCG), a rare subset of central nervous system (CNS) glioma, represents complex challenge in neuro-oncology. There has been research showing that Retinol Dehydrogenase 10 (RDH10) may be tumor promoting factor brain but the biological effects RDH10 remain undefined SCG. Methods: We performed gene set enrichment analysis (GSEA) and unsupervised clustering to investigate roles EMT (epithelial-mesenchymal transition) glioma. DEG (differently expressed gene)...
Abstract Background: Glioma has a high mortality and can hardly be completely cured. Radix Paeoniae Rubra (RPR) is prevalent component in traditional Chinese medicine used for tumor treatments. We explored the mechanism of RPR treating glioma using network pharmacology experiments. Methods: A approach was to screen active ingredients, targets glioma. then constructed herb-active ingredient-target-pathway conducted Protein-Protein Interaction (PPI) analysis, as well Gene Ontology (GO) Kyoto...