A5101650532- Intracerebral and Subarachnoid Hemorrhage Research
- Robotic Locomotion and Control
- Microtubule and mitosis dynamics
- Cellular Mechanics and Interactions
- Photonic and Optical Devices
- Railway Engineering and Dynamics
- Advanced optical system design
- Soil Mechanics and Vehicle Dynamics
- Prosthetics and Rehabilitation Robotics
- Civil and Geotechnical Engineering Research
- Robotic Mechanisms and Dynamics
- Optical Systems and Laser Technology
- Graphene and Nanomaterials Applications
- Alzheimer's disease research and treatments
- Geotechnical Engineering and Underground Structures
- Advanced Nanomaterials in Catalysis
- Manufacturing Process and Optimization
- Neuroinflammation and Neurodegeneration Mechanisms
- Image Processing Techniques and Applications
- Electrowetting and Microfluidic Technologies
- Machine Learning in Bioinformatics
- Plant Molecular Biology Research
- Tactile and Sensory Interactions
- Infrastructure Maintenance and Monitoring
- Electromagnetic Fields and Biological Effects
Hebei Medical University
2018-2025
Second Hospital of Hebei Medical University
2018-2025
Dalian Minzu University
2025
Hebei University
2025
Tencent (China)
2023-2024
Southwest Jiaotong University
2024
Inner Mongolia University
2024
Chongqing Jiaotong University
2022-2024
Yanshan University
2024
Institute of Optics and Electronics, Chinese Academy of Sciences
2022-2023
Humans can perceive our complex world through multi-sensory fusion. Under limited visual conditions, people sense a variety of tactile signals to identify objects accurately and rapidly. However, replicating this unique capability in robots remains significant challenge. Here, we present new form ultralight multifunctional nano-layered carbon aerogel sensor that provides pressure, temperature, material recognition 3D location capabilities, which is combined with multimodal supervised...
This paper conducts a comparative study on the severity, development trends of rail corrugation, and suppression effects vibration absorbers small-radius curved track sections supported by two types typical fasteners. Firstly, finite element model (FEM) wheel-rail system for is established based field investigation data. Then, analysis conducted frictional coupling characteristics wear surface systems in fastener sections. Additionally, effect installing corrugation analyzed. The results...
The abuse of antibiotics has led to the emergence numerous super resistant bacteria, which pose a serious threat public health. Developing nanomaterials with novel modes bactericidal activity offers promise fighting pathogens without risk causing drug resistances. Here, we used reduced graphene oxide (rGO), bulk molybdenum disulfide (MoS2) and silver nitrate (AgNO3) synthesize ternary nanocomposite, rGO-MoS2-Ag, via simple one-pot method. resulting rGO-MoS2-Ag presented as crumpled...
To enrich legged robots with fast energy-efficient mobility on even terrain, wheeled-legged have emerged as a valued robot form in robotics research. This paper describes the complete development of new quadruped named Max, ranging from its mechanical design over system architecture to core algorithms implemented for it realize various motion behaviors. Instead attaching wheels distal ends legs existing designs, this has installed knees special switching mechanism convert leg between and...
Pink1 (PTEN-induced putative kinase 1) is a protein associated with maintaining mitochondrial function and integrity has been reported to mediate neurodegeneration neuroinflammation. While the role of in intracerebral hemorrhage (ICH)-related neurological deficits inflammatory responses not deciphered. Congenic blood was transfused into left corpus striatum construct ICH model C57/BL6 wild-type (WT) Pink1−/− mice. The relative expression Pink1, monocyte chemoattractant protein-1 (MCP-1),...
Background and Objective: Exosomes communicate inter-cellularly miRNAs play critical roles in this scenario. MiR-214-5p was implicated multiple tumors with diverse functions uncovered. However, whether miR-214-5p is mechanistically involved glioblastoma, especially via exosomal pathway, still elusive. Here we sought to comprehensively address the role of glioblastoma (GBM) microenvironment. Methods: The relative expression determined by real-time PCR. Cell viability migration were measured...
Cell division orientation plays an essential role in tissue morphogenesis and cell fate decision. Recent studies showed that either shape or adhesion geometry can regulate the of mitotic spindles thereby orientation. However, how they together spindle remains largely unclear. In this work, we use a general computational model to investigate competitive mechanism determining between intercellular epithelial cells. We find is dominated by when anisotropy small, but large. A strong moderate...
In this paper, the adaptive liquid (AL) lenses are introduced into double-sided telecentric zoom system, which could greatly decrease mechanical motion group compared with traditional and only one movable aperture stop (STO) is retained. Firstly, paper derived Gaussian brackets used in we found appropriate screening method to get suitable initial structure parameters from solution space. Then lens module design create system. Finally, CODEV further optimize got an excellent result,...
Accumulating studies have demonstrated that neuronal autophagy and inflammation are crucial for hippocampus development in rats subjected to traumatic brain injury (TBI). Therefore, we investigated whether resveratrol is protective against damage through the attenuation of inflammation, explored underlying mechanisms.Rats were injected with (50 mg/kg, i.p.), following controlled cortical impact (CCI) injury. Brain water content, behavioral studies, mNSS score measured assess effects...
Objectives: Our study aimed to explore the effects of quercetin on glioma stem cells in patients with brain tumors. Methods: Human glioblastoma cell line, U373MG, or lines, were treated quercetin. Cell viability was determined by using counting kit 8 assays. apoptosis Annexin-V reagent. Western blotting and qPCR used detect protein mRNA levels cyclindependent kinase inhibitor 2A (p16INK4a). Chromatin immunoprecipitation analysis determine enrichment H3K27me3 p16-INK4 locus without Results:...
Rheumatoid arthritis (RA) is a prevalent autoimmune disease, affecting approximately 1% of the global population. Methotrexate (MTX) most widely prescribed drug for RA treatment; however, its efficacy often limited, with resistance frequently observed. Fibroblast-like synoviocytes (FLS) play pivotal role in progression and are closely linked to resistance, although underlying mechanisms remain poorly understood. In this study, we conducted comprehensive analysis public single-cell...
Epithelial monolayers are subjected to various mechanical forces, such as stretching, shearing, and compression. Thus, its response external loadings is essential for biological functions. However, the mechanism of fracture failure epithelial monolayer remains poorly understood. Here, by introducing a new type topological transition, i.e., detach transition or T4 we develop modified cellular vertex model investigate rupture cell monolayer. Interestingly, find brittle-to-ductile in...
Intracerebral hemorrhage (ICH) causes neurotransmitter release, oligemia, membrane depolarization, mitochondrial dysfunction, and results in the high rate of mortality functional disability. Here, we focus on PTEN-induced kinase 1 (PINK1), a mitochondrial-targeted protein kinase, explore its role ICH progression.The qPCR Western blot were performed to examine expression PINK1 patients mouse model. gain- loss-of-function mice used evaluate their protective brain injury behavioral disorders....
One of the major topics in magnetobiology is biological effects strong static magnetic field (SMF) on living organisms. However, there has been a paucity comprehensive study long-term SMF an animal's development. Here, we explored this question with zebrafish, excellent model organism for developmental study. In our research, zebrafish eggs, just after fertilization, were exposed to 9.0 T 24 h, critical period post-fertilization development from cleavage segmentation. The exposure following...
Multipolar spindles are very rare in normal tissues, but they much more prevalent many tumors, which might be induced by the mechanical confinements from overcrowding microenvironments tumors. However, little is known about what difference between various forms of that cells encounter tissues and tumor how affect multipolarity chromosome segregation fidelity. Here, we use microchannels with different heights widths to mimic diverse degrees constraints within tissue architecture. We find...
The working distance of the high numerical aperture visible video microscope is extremely short, which greatly limits its application scenarios. To solve this problem, paper proposes an unobstructed design method double-sided telecentric with and long distance. First, aiming at obstruction problem image-side catadioptric objective, structure optical system improved. Then, aspheric based on best aberration compensation analyzed theoretically to better correct primary high-numerical objective....