A5101767806- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Force Microscopy Techniques and Applications
- Micro and Nano Robotics
- Microtubule and mitosis dynamics
- Microfluidic and Bio-sensing Technologies
- Lipid Membrane Structure and Behavior
- Hippo pathway signaling and YAP/TAZ
- Bacterial Genetics and Biotechnology
- Pickering emulsions and particle stabilization
- Bacteriophages and microbial interactions
- Spaceflight effects on biology
- Adhesion, Friction, and Surface Interactions
- Ovarian cancer diagnosis and treatment
- Surface Modification and Superhydrophobicity
- Endometrial and Cervical Cancer Treatments
- Nanopore and Nanochannel Transport Studies
- Modular Robots and Swarm Intelligence
- Bacterial biofilms and quorum sensing
- RNA modifications and cancer
- Magnetic and Electromagnetic Effects
- Cancer-related molecular mechanisms research
- Wnt/β-catenin signaling in development and cancer
- Optical Coatings and Gratings
- DNA and Nucleic Acid Chemistry
University of Science and Technology of China
2015-2025
Qingdao University
2024
Affiliated Hospital of Qingdao University
2024
Changhai Hospital
2023
Second Military Medical University
2023
Oxford Health NHS Foundation Trust
2021
University of Oxford
2021
Hefei National Center for Physical Sciences at Nanoscale
2019-2020
Center for Excellence in Education
2020
Obstetrics and Gynecology Hospital of Fudan University
2004-2020
In eukaryotic cells, small changes in cell volume can serve as important signals for proliferation, death, and migration. Volume shape regulation also directly impacts the mechanics of cells tissues. Here, we develop a mathematical model cellular pressure regulation, incorporating essential elements such water permeation, mechanosensitive channels, active ion pumps, stresses cortex. The fully explain recent experimental data, it predicts several models cortical mechanics. Moreover, show that...
Motivated by the observed coordination of nearby beating cilia, we use a scale model experiment to show that hydrodynamic interactions can cause synchronization between rotating paddles driven at constant torque in very viscous fluid. Synchronization is only when shafts supporting have some flexibility. The phase difference synchronized state depends on symmetry paddles. We method regularized stokeslets and find excellent agreement with experimental observations. also simple analytic theory...
Abstract Formation of telephone cord blisters as a result buckling delamination is widely observed in many compressed film-substrate systems. Here we report universal morphological feature such characterized by their sequential sectional profiles exhibiting butterfly shape using atomic force microscopy. Two kinds buckle morphologies, light and heavy blisters, are differentiated measurable geometrical parameters. Based on the Föppl-von Kármán plate theory, three-dimensional features blister...
Mechanical property of dumbbell-like Au−Fe3O4 nanoparticles (NPs) is investigated from a synthetic point view by overgrowing Au2 on the Au1−Fe3O4 NPs. The competitive growth preformed NPs induced an interesting "tug-of-war" between and Fe3O4 in formed Au2−Au1−Fe3O4 ternary nanostructure. An interpretation observed phenomena proposed based mechanical analysis stress strain distribution across nanoparticle, which further verified control experiments with particle size tuned.
Bacterial cells utilize a living peptidoglycan network (PG) to separate the cell interior from surroundings. The shape of is controlled by PG synthesis and cytoskeletal proteins that form bundles filaments underneath wall. layer also resists turgor pressure protects osmotic shock. We argue mechanical influences alter chemical equilibrium reversible assembly determine size. Using mechanochemical approach, we show can be regarded as steady state growing under influence stress. simple elastic...
The failure of reproductive success in polycystic ovary syndrome (PCOS) patients could be part due to endometrial dysfunction.However, no studies have investigated any causality between androgen, androgen receptor (AR) expression, and adenosine monophosphate activated protein kinase (AMPK) activation the endometrium under physiological pathological conditions.In present study, we show that 1) AR expression levels fluctuate non-PCOS PCOS during menstrual cycle; 2) phase-dependent alteration...
Tanshinone IIA (TanIIA)-an active constituent of Salvia miltiorrhiza, a traditional Chinese medicinal plant-is known to have blood circulation promotion and anti-tumor properties.Tan can induce tumor cell death inhibit growth.However, the functions underling molecular mechanisms Tan action on human liver cancer cells remain poorly understand.In this study, we found that mediates SMAD7-YAP interaction apoptosis growth migration by inactivating transforming factor beta (TGF-β) signaling...
The highly aligned extracellular matrix of metastatic breast cancer cells is considered to be the "highway" invasion, which strongly promotes directional migration break through basement membrane. However, how reorganized regulates cell remains unknown. Here, a single exposure femtosecond Airy beam followed by capillary-assisted self-assembly process was used fabricate microclaw-array, mimic oriented tumor and pores in or membrane during invasion. Through experiment, we found that MDA-MB-231...
The characteristics of the directed transport liquids based on Janus membranes play a crucial role in practical applications energy, materials, physics, chemistry, medicine, biology, and other fields. Although extensive progress has been made, it is still difficult to realize accurate controllability liquid directional transmembrane transport. current gating strategies for have some limitations: (a) using magnetic fluid may cause contamination due addition new substances (b) utilizing...
Abstract Membrane class I MHC molecules of Con-A activated and lymphoma murine cells have been labeled by exchange the cell's beta 2m with soluble fl-beta 2m. It has previously shown that this method labeling is specific does not affect biologic properties Ag. With it possible to demonstrate constitutive endocytosis fluorescence microscopy measuring resistance quenching crystal violet internalized molecules. We could also follow kinetics dissociation from at different pH. At pH 5.5, average...
In this paper, we present a focused femtosecond laser Bessel beam scanning technique for the rapid fabrication of large-area 3D complex microtube arrays. The is converted into several beams by two-dimensional phase modulation using spatial light modulator. By along designed route, microtubes with variable size and flexible geometry are rapidly fabricated two-photon polymerization. time reduced two orders magnitude in comparison conventional point-to-point scanning. Moreover, construct an...
For unresectable Hepatocellular carcinoma (HCC), chemotherapy is still an important treatment strategy. Oxaliplatin (Oxa) effective of HCC after sorafenib failure. However, the intrinsic or acquired resistance Oxa affected chemotherapeutic sensitivity. By analyzing data GEO Database, we found that aberrantly increased expression Cysteine-rich61 (Cyr61) in cell lines. Subsequently, Bel-7404 and SMMC-7721 cells treated with Oxa, it was verified Cyr61 Yes-associated protein (YAP) increased....
Cell division orientation plays an essential role in tissue morphogenesis and cell fate decision. Recent studies showed that either shape or adhesion geometry can regulate the of mitotic spindles thereby orientation. However, how they together spindle remains largely unclear. In this work, we use a general computational model to investigate competitive mechanism determining between intercellular epithelial cells. We find is dominated by when anisotropy small, but large. A strong moderate...
The effect of mechanical disturbance on one-dimensional nanocrystal growth in solution phase is investigated by controlled Au nanowires with and without stirring. While a static leads to straight, single-crystal nanowires, the mechanic stirring tends bend nanowire growth, yielding kinks abundant various types crystal defects including dislocations, twin boundaries, grain boundaries. Mechanical modeling analysis introduced elucidate mechanisms these two conditions. provided fundamental...
To investigate the immune mechanism of osteosarcoma (OS)-specific markers to mitigate bone destruction in aggressive OS, prone recurrence and metastasis.