IMPORTANCE Appropriate antibiotic use is a key strategy to control antibacterial resistance.The first step in achieving this identify the major problems prescription health care facilities, especially primary settings, which where most patients receive medical care.OBJECTIVE To current patterns of and explore reasons for inappropriate settings China. DESIGN, SETTING, AND PARTICIPANTSA total 48 facilities China were randomly selected from 6 provinces at various levels economic...

<h3>Importance</h3> Perioperative respiratory adverse events (PRAEs) are the most common complication during pediatric anesthesia, and they may be affected by administration of preoperative sedatives. <h3>Objective</h3> To investigate effect intranasal dexmedetomidine or midazolam used for premedication on occurrence PRAEs. <h3>Design, Setting, Participants</h3> This single-center, double-blind, randomized clinical trial was conducted among children aged 0 to 12 years undergoing elective...

N-rGO enriches N -glycans/glycopeptides via HILIC and directly identifies them using MALDI-TOF MS.

Excessive CO 2 emissions and increased total costs of liner shipping are the two main problems affecting environmental economic benefits companies under European Union Emission Trading System (EU ETS). To address upcoming EU ETS, we propose a carbon cost accounting model for that accurately calculates shipping. We conduct case study containership operates on route from Far East to Northwest Europe. The results show sailing stage plays pivotal role in shipping, 94.70% emissions. Among four...

Importance The efficacy of a semirecumbent position (SRP) in reducing postoperative hypoxemia during anesthesia emergence is unclear despite its widespread use. Objective To determine the differences between patients an SRP and supine position. Design, Setting, Participants This randomized clinical trial was performed at tertiary hospital China March 20, 2021, May 10, 2022. Patients scheduled to undergo laparoscopic upper abdominal surgery under general were enrolled. Study recruitment...

The clinical application of macromolecular Gd(III) complexes as MRI contrast agents is impeded by their slow excretion and potential toxicity due to the release ions caused metabolism agents. A polymer chelate conjugate with a cleavable spacer has been designed solve this problem. Poly(l-glutamic acid)-cystamine-[Gd(III)-DOTA] was prepared conjugation DOTA PGA (MW = 50,000) via cystamine, disulfide spacer, followed complexation GdCl(3). derivative readily released from in incubation...

Tanshinone IIA (TanIIA)-an active constituent of Salvia miltiorrhiza, a traditional Chinese medicinal plant-is known to have blood circulation promotion and anti-tumor properties.Tan can induce tumor cell death inhibit growth.However, the functions underling molecular mechanisms Tan action on human liver cancer cells remain poorly understand.In this study, we found that mediates SMAD7-YAP interaction apoptosis growth migration by inactivating transforming factor beta (TGF-β) signaling...

Abstract Background Sarcopenia and frailty are both age‐related declines in functional reserve that linked to adverse health outcomes. It is critical know about the outcomes of a combination these conditions. The study aimed investigate effects sarcopenia on postoperative recovery elderly patients explore risk factors. Methods This prospective cohort was conducted among 608 aged ≥60 years, American Society Anesthesiologists I‐III, who were scheduled undergo thoracic (non‐cardiac) abdominal...

Biodegradable PEGylated Gd-DTPA l-cystine copolymers, PEG-g-poly(GdDTPA-co-l-cystine), were prepared and tested as a blood pool contrast agent in mice. The biodegradable macromolecular was designed to be broken down into smaller Gd complexes by endogenous thiols via the disulfide−thiol exchange reaction facilitate clearance of after contrast-enhanced MRI examination. copolymers synthesized condensation polymerization DTPA-dianhydride water followed chelating with Gd(OAc)3. MPEG-NH2 (MW =...

Ovarian cancer is one of the most common gynecological tumors worldwide. Despite availability multiple treatments for ovarian cancer, its resistance to chemotherapy remains a significant challenge. miRNAs play crucial roles in initiation and progression by affecting processes such as differentiation, proliferation, chemoresistance. According microarray qPCR analyses, miR-7704 significantly downregulated cisplatin-resistant cells compared parental cells. In this study, we found that inhibited...

Background The protective effects of metformin (Met) against doxorubicin (Dox)-induced cardiotoxicity via potential hypotheses mechanisms action with unknown reliability and credibility. Objectives This study aimed to investigate the Met Dox-induced underlying action, as well examine their Methods A comprehensive search was conducted within PubMed, Embase, Web Science, Science Direct, Scopus, CNKI databases from inception 31 December 2023. Animal experiments evaluating efficacy were included...

Abstract The clinical application of macromolecular gadolinium (Gd) complexes as MRI contrast agents is limited by the slow excretion Gd(III) and consequent long‐term tissue accumulation toxic Gd ions. To alleviate problem excretion, biodegradable polydisulfide‐based were designed prepared based on disulfide‐thiol exchange to allow degradation macromolecules endogenous thiols facilitate after examination. in vitro study showed that polydisulfide agent was readily degraded cysteine at plasma...

Abstract The structures of polydisulfide‐based biodegradable macromolecular Gd(III) complexes were modified to improve their in vivo retention time and MRI contrast enhancement. Steric hindrance was introduced around the disulfide bonds control access free thiols order alter degradation rate copolymers. Two new agents, (Gd‐DTPA)‐cystine copolymers (GDCP) diethyl ester (GDCEP), prepared. Both agents readily degraded vitro by disulfide‐thiol exchange reaction, but at a slow rate. introduction...

The effects of food on the pharmacokinetics and safety metformin hydrochloride (MH) are unclear.To discover MH, its influence factors.English Chinese databases, grey (unpublished) literature were searched for eligible studies (registration No. CRD 42022321067 in PROSPERO network). summary weighted mean difference continuous variables, risk ratio dichotomous variables was calculated main pharmacokinetic parameters. Heterogeneity among included analyzed using I2 test. Subgroup analyses,...

Abstract Glycosylation alterations have emerged as significant indicators in the landscape of cancer diagnosis, with aberrant N-glycans standing out potential biomarkers. The existing methods for purifying mainly rely on their hydrophilicity, affinity, and size. These exhibit relatively weak binding forces low specificity based non-covalent interactions. Moreover, current liquid chromatography-based N-glycan purification detection techniques must be bettered clinical settings' rapid...

To explore the effect of transcutaneous auricular vagus nerve stimulation (taVNS) combined with patient-controlled intravenous analgesia (PCIA) on postoperative pain in patients undergoing total knee arthroplasty (TKA). A 140 TKA were randomly divided into taVNS group (n=70, 5 dropped-out) and sham 6 dropped-out). The received at left ear conchae PCIA treatment, while treatment. time-weighted average (TWA) score, visual analogue scale (VAS) score 1-7 days after surgery, occurrence adverse...

Background This research aimed to compare the bioequivalence of a test formulation (regorafenib produced by Beijing SL Pharmaceutical Co., Ltd.) with reference (the original drug Stivarga ® ) in Chinese healthy subjects under fasting conditions and two postprandial states: after low-fat high-fat meals. Methods The design was randomized, open-label, two-period crossover trial involving single 40 mg oral dose. Three separate studies were conducted. Study 1 enrolled 64 who dosed conditions; 2...

To investigate the effect of intravenous lidocaine on postoperative fatigue syndrome (POFS) in laparoscopic radical colorectal cancer surgery patients, a randomized controlled trial enrolled 86 patients aged over 18 with preoperative Christensen score ≤ 4 at Xuzhou Central Hospital from September 2023 to June 2024. The group (group L) received an infusion 1.5 mg·kg-1 for 15 min, 30 min prior anesthetic induction, followed by sustained mg·kg- 1·h- 1 until surgical closure. control C) equal...

Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors. Upregulation metastasis-associated protein 1 (MTA1) has been reported to contribute development esophageal carcinoma. Therefore, objective our study was identify molecular mechanisms MTA1 underlying invasion and metastasis ESCC. We overexpressed in ESCC cells examine role regulation invasion. In addition, using luciferase reporter assay electrophoretic mobility shift assays, we evaluated binding promoter...