A5101724582- Retinal Imaging and Analysis
- Cyclopropane Reaction Mechanisms
- Retinal Diseases and Treatments
- Advanced Multi-Objective Optimization Algorithms
- Titanium Alloys Microstructure and Properties
- Catalytic C–H Functionalization Methods
- Additive Manufacturing Materials and Processes
- Advanced materials and composites
- Landslides and related hazards
- Aluminum Alloys Composites Properties
- Asphalt Pavement Performance Evaluation
- Metal and Thin Film Mechanics
- Nanoplatforms for cancer theranostics
- Glaucoma and retinal disorders
- High Entropy Alloys Studies
- Metal Alloys Wear and Properties
- Vehicle Routing Optimization Methods
- Optical Coherence Tomography Applications
- Geotechnical Engineering and Analysis
- Remote-Sensing Image Classification
- AI in cancer detection
- Infrastructure Maintenance and Monitoring
- Cancer Immunotherapy and Biomarkers
- Soil and Unsaturated Flow
- Catalytic Alkyne Reactions
Guangdong Polytechnic Normal University
2018-2025
Nanjing University
2025
Xi'an Jiaotong University
2025
State Intellectual Property Office
2024
Nanchang Hangkong University
2024
Shougang Institute of Technology
2024
Wuhan University of Technology
2024
Ministry of Transport
2023-2024
Pennsylvania State University
2023-2024
China Three Gorges University
2024
Abstract Background Conventional immunohistochemistry technologies were limited by the inability to simultaneously detect multiple markers and lack of identifying spatial relationships among cells, hindering understanding biological processes in cancer immunology. Methods Tissue slices primary tumours from 553 IA∼IIIB non‐small cell lung (NSCLC) cases stained multiplex immunofluorescence (mIF) assay for 10 markers, including CD4, CD38, CD20, FOXP3, CD66b, CD8, CD68, PD‐L1, CD133 CD163,...
Abstract Ferroptosis is a regulatory cell death that dependent on iron‐mediated lipid peroxidation and membrane damage. The use of iron‐based nanocarriers to activate ferroptosis great significance in oncotherapy. However, the limited endogenous hydrogen peroxide (H 2 O ) high expression glutathione (GSH) tumor cells restrict efficiency inducing ferroptosis. Herein, ferric phosphate nanotherapeutic system (denoted as FeP@HCPT‐HA) reported with H ‐supply GSH‐elimination properties for...
Abstract The development of thermally stable separators is a promising approach to address the safety issues lithium‐ion batteries (LIBs) owing serious shrinkage commercial polyolefin at elevated temperatures. However, achieving controlled nanopores with uniform size distribution in thermostable polymeric and high electrochemical performance still great challenge. In this study, nanoporous polyimide (PI) membranes excellent thermal stability as high‐safety developed for LIBs using...
The rheumatoid arthritis (RA) microenvironment is often followed by a vicious circle of high inflammation, endogenous gas levels imbalance, and poor treatment. To break the circle, we develop dual-gas-mediated injectable hydrogel for modulating immune RA simultaneously releasing therapeutic drugs. (DNRS gel) could be broken down on-demand consuming excessive nitric oxide (NO) hydrogen sulfide (H
Mesenchymal stem cell (MSC) administration is known to enhance the recovery of kidney following injury. Here we tested potential hypoxic-preconditioned-MSC transplantation efficacy therapy on acute injury (AKI) by improving MSC migration injured kidney. Cobalt was used as hypoxia mimetic preconditioning (HMP). were subjected HMP through 24 h culture in 200 µmol/L cobalt. Compared normoxia cultured (NP-MSC), significantly increased expression HIF-1α and CXCR4 enhanced vitro. This effect lost...
Abstract Background Due to the lack of research on pathological mechanism temporomandibular joint osteoarthritis (TMJOA), there are few effective treatment measures in clinic. In recent years, microRNAs (miRs) have been demonstrated play an important role pathogenesis (OA) by regulating a variety target genes, and latest evidence shows that miR-21-5p is specifically overexpressed OA. The purpose this project was clarify whether can regulate TMJOA process targeting Spry1. Methods induced...
The conversion of inexpensive aqueous ammonia (NH3·H2O) into value-added primary amines by N-H insertion persists as a longstanding challenge in chemistry because the tendency Lewis basic (NH3) to bind and inhibit metal catalysts. Herein, we report chemoselective carbene NH3·H2O using TpBr3Ag-catalyzed two-phase system. Coordination homoscorpionate TpBr3 ligand renders silver compatible with NH3 H2O enables generation electrophilic carbene. Water promotes subsequent [1,2]-proton shift...
Friction stir lap welding (FSLW) was adopted to join successfully dissimilar AZ31B Mg alloy and TC4 Ti with Sn foil addition of 30 µm thickness. Interfacial microstructure, tensile shear performances bonding mechanism the joints obtained using three different rotation speeds were studied. High-performance FSLW Mg/Ti maximum strength 593.3 N/mm produced at 1180 r/min, which mainly attributed ultrastrong reaction interlayer consisting 125.9 nm thick (Mg2Sn+Mg) transition layer discontinuous...
The cellular dynamics in the tumour microenvironment (TME) along with non-small cell lung cancer (NSCLC) progression remain unclear.Multiplex immunofluorescence test detecting 10 immune-related markers on 553 primary (PT) samples of NSCLC was conducted and spatial information TME assessed by StarDist depth learning model. single-cell transcriptomic atlas PT (n = 4) paired tumour-draining lymph nodes (TDLNs) 5 for tumour-invaded, n 3 tumour-free) profiled. Various bioinformatics analyses...
High Temperature may exert a great impact on the service life and reliability of friction materials during sliding. Tribological behavior new developed copper metal matrix composite (Cu-MMC) against steel disc was investigated using home-built pin-on-disc tribometer in ambient temperature range 25–800 °C. Detailed analyses worn surfaces subsurfaces were performed scanning electron microscope, optical X-ray diffractometer 3D profiler. The surface Cu-MMC exhibited different features at various...
The construction of allylic quaternary sp3 -carbon centers has long been a formidable challenge in transition-metal-catalyzed alkyl-allyl coupling reactions due to the severe steric hindrance. Herein, we report an effective carbene strategy that employs well-defined vinyl-N-triftosylhydrazones as versatile allylating reagent enable direct assembly these medicinally desirable structural elements from low-cost alkane feedstocks. reaction exhibited excellent site selectivity for tertiary C-H...
Background/aims The aim of this study was to develop and evaluate digital ray, based on preoperative postoperative image pairs using style transfer generative adversarial networks (GANs), enhance cataractous fundus images for improved retinopathy detection. Methods For eligible cataract patients, colour photographs (CFP) ultra-wide field (UWF) were captured. Then, both the original CycleGAN a modified (C 2 ycleGAN) framework adopted generation quantitatively compared Frechet Inception...
Knowledge-aware recommendation systems often face challenges owing to sparse supervision signals and redundant entity relations, which can diminish the advantages of utilizing knowledge graphs for enhancing performance. To tackle these challenges, we propose a novel model named Dual-Intent-View Contrastive Learning network (DIVCL), inspired by recent advancements in contrastive intent learning. DIVCL employs dual-view representation learning approach using Graph Neural Networks (GNNs),...
Diabetic macular edema (DME) stands as a leading cause for vision loss among the working-age population. Anti-vascular endothelial growth factor (VEGF) agents are currently recognized first-line treatment. However, significant portion of patients remain insensitive to anti-VEGF, resulting in sustained visual impairment. Therefore, it's imperative predict prognosis and formulate personalized therapeutic regimens. Generative adversarial networks (GANs) have demonstrated remarkably forecasting...