A5100626916- Microbial Metabolites in Food Biotechnology
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- Antimicrobial Peptides and Activities
- Cancer Research and Treatments
- Bacteriophages and microbial interactions
- Influenza Virus Research Studies
- Toxin Mechanisms and Immunotoxins
- RNA and protein synthesis mechanisms
- Immunotherapy and Immune Responses
- Cervical Cancer and HPV Research
- vaccines and immunoinformatics approaches
- interferon and immune responses
- RNA modifications and cancer
- Respiratory viral infections research
- Nanoparticle-Based Drug Delivery
- Machine Learning in Bioinformatics
- Helicobacter pylori-related gastroenterology studies
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- Nanoplatforms for cancer theranostics
- Phytochemicals and Antioxidant Activities
- Hepatitis B Virus Studies
- Advanced biosensing and bioanalysis techniques
- Virus-based gene therapy research
Jilin University
2023-2025
Chinese University of Hong Kong
2025
Beijing National Laboratory for Molecular Sciences
2025
Peking University
2025
Johns Hopkins University
2024
Shanghai Ocean University
2024
Tianjin University of Science and Technology
2019-2024
China International Science and Technology Cooperation
2019-2024
Sun Yat-sen University
2024
Liaocheng University
2023
Some studies have shown that lyophilization significantly improves the stability of mRNA-LNPs and enables long-term storage at 2-8 °C. However, there is little research on process mRNA-lipid nanoparticles (LNPs). Most previous used empirical with only a single lyoprotectant, resulting in low efficiency, often requiring 40-100 h. In present study, an efficient method suitable for was designed optimized, shortening total length to 8-18 h, which reduced energy consumption production costs. When...
Abstract Background Antimicrobial resistance is one of our most serious health threats. peptides (AMPs), effecter molecules innate immune system, can defend host organisms against microbes and have shown a lowered likelihood for bacteria to form compared many conventional drugs. Thus, AMPs are gaining popularity as better substitute antibiotics. To aid researchers in novel discovery, we design computational approaches screen promising candidates. Results In this work, deep learning model...
A comprehensive analysis of the humoral immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential in understanding COVID-19 pathogenesis and developing antibody-based diagnostics therapy. In this work, we performed a longitudinal antibody responses SARS-CoV-2 proteins 104 serum samples from 49 critical patients using peptide-based proteome microarray. Our data show that binding epitopes IgM IgG antibodies differ across even within same protein. Moreover,...
In the present study, we prepared collagen liposomes with addition of polyol, which is expected to not only increase solubility but also improve skin penetration.Collagen were by film dispersion method, and their characteristics, integrity biosafety evaluated Fourier transform infrared spectroscopy (FTIR), UV-VIS spectroscopy, polyacrylamide gel electrophoresis (SDS-PAGE), dynamic light scattering (DLS) transmission electron microscope (TEM). The transdermal absorption tested an ex vivo...
Abstract Understanding viral replication and transcription mechanisms is critical for developing effective antiviral strategies. The study of gene regulation in host cellular environment an important bridge translating mechanistic discoveries from vitro studies to vivo but it remains stagnated due the absence technological advancement. Current methods studying have been limited capturing only mature RNAs, obscuring dynamic intermediates details these crucial processes. Here, we introduce...
Abstract Layered 2D semiconductors, when grown into 1D nanowires, can exhibit excellent optical and electronic properties, promising for nanoscale optoelectronics photonics. However, rational strategies to grow such nanowires are lacking. Here, we present a large family of quantum-well made from organic-inorganic hybrid metal halide perovskites with tunable well thickness, organic spacer cations, anions, achieved by harnessing directional nonvalent intermolecular interactions among certain...
Endoplasmic reticulum (ER) stress has been implicated in the pathophysiology of various pulmonary diseases via activation unfolded protein response. However, role ER arterial hypertension (PAH) remains unclear. The well-known chemical chaperone 4-phenylbutyric acid (4-PBA) inhibits signaling. We hypothesized that known chaperones, including 4-PBA, would inhibit and prevent and/or reverse PAH.
Abstract Background Membrane proteins play an important role in the life activities of organisms. Knowing membrane protein types provides clues for understanding structure and function proteins. Though various computational methods predicting have been developed, results still do not meet expectations researchers. Results We propose two deep learning models to process sequence information evolutionary information, respectively. Both obtained better than traditional machine models....
Chronic gastric infection by the Gram-negative bacterium Helicobacter pylori (H. pylori) is strongly associated with gastritis, ulcer and development of distal carcinoma mucosal lymphoma in humans. Antibiotic treatment H. becoming less effective because increasing antibiotic resistance; other approaches such as specifically targeted methods, etc. to destroy this organism would be beneficial. An epitope vaccine a promising option for protection against infection. In study, multi-epitope was...
This study aims to investigate the regulative effects of microRNA-451a (miR-451a) on cell proliferation and sensitivity tamoxifen in breast cancer cells. In culture experiments, lentiviral vectors pHBLV-miR-451a sponge were constructed used transfect MCF-7 LCC2 The transfection efficiency was tested by fluorescent observation, lines with stable over- or downregulated expression miR-451a established. target gene macrophage migration inhibitory factor (MIF) detected real-time reverse...
Background/aims The aim of this study was to develop and evaluate digital ray, based on preoperative postoperative image pairs using style transfer generative adversarial networks (GANs), enhance cataractous fundus images for improved retinopathy detection. Methods For eligible cataract patients, colour photographs (CFP) ultra-wide field (UWF) were captured. Then, both the original CycleGAN a modified (C 2 ycleGAN) framework adopted generation quantitatively compared Frechet Inception...
Background: Influenza causes significant morbidity and mortality. Mammalian β-defensins are small peptides of about 4.5–6 kDa in mass effectors the innate immune response with potent antimicrobial activity. In this paper, we focused on anti-influenza A activity recombinant mouse β-defensin 3 (rMBD-3) vivo vitro. Methods: The rMBD-3 peptide was added to Madin-Darby canine kidney (MDCK) cells at different stages influenza virus (IAV) A/PR/8/34 (H1N1) infection its inhibitory properties were...