A5025615610- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- Light effects on plants
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Cancer-related molecular mechanisms research
- Antimicrobial Peptides and Activities
- Gallbladder and Bile Duct Disorders
- RNA modifications and cancer
- Breast Cancer Treatment Studies
- AI in cancer detection
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- HER2/EGFR in Cancer Research
- MRI in cancer diagnosis
- Global Cancer Incidence and Screening
- Circular RNAs in diseases
- Endometrial and Cervical Cancer Treatments
- Immune Response and Inflammation
- Mitochondrial Function and Pathology
Ningbo Medical Center Lihuili Hospital
2023-2025
Tianjin University
2025
Changsha Medical University
2015-2024
Wuhan Textile University
2024
Second Affiliated Hospital of Zhejiang University
2024
Tsinghua University
2006-2024
Geological Survey of Canada
2024
University of Victoria
2024
Gansu Provincial Hospital
2022-2024
Dalian Medical University
2017-2024
Abstract Background High invasion and metastasis are the primary factors causing poor prognosis of patients with hepatocellular carcinoma (HCC). However, molecular mechanisms underlying these biological behaviors have not been completely elucidated. In this study, we investigate mechanism by which hypoxia promotes HCC through inducing epithelial-mesenchymal transition (EMT). Methods The expression EMT markers was analyzed immunohistochemistry. Effect on induction ability cell migration were...
Significance CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) and ELONGATED HYPOCOTYL 5 (HY5) are two central regulators of photomorphogenesis. COP1 destabilizes HY5 to repress photomorphogenesis in darkness. On light illumination, accumulated regulates the expression a large number genes optimize Thus, COP1-HY5 defines regulatory hub for control seedling development. In this work, our data indicate that BBX21 is key component involved hub. controlled by via its E3 ubiquitin ligase activity light,...
Light is one of the most important environmental cues regulating multiple aspects plant growth and development, abscisic acid (ABA) a hormone that plays roles during many phases life cycle in plants' responses to various stresses. How plants integrate external light signal with endogenous ABA pathway for better adaptation survival remains poorly understood. Here, we show BBX21 (also known as SALT TOLERANCE HOMOLOG 2), B-box (BBX) protein previously shown positively regulate seedling...
Plants have evolved a delicate molecular system to fine-tune their growth and development in response dynamically changing light environments. In this study, we found that BBX28, B-box domain protein, negatively regulates photomorphogenic dose-dependent manner Arabidopsis thaliana. BBX28 interferes with the binding of transcription factor HY5 promoters its target genes through physical interactions, thereby repressing activity affecting HY5-regulated gene expression. darkness, associates...
// Jian-Jie Zhao 1 , Shuai Hao Ling-Li Wang Chun-Yan Hu Shu Zhang Ling-Ji Guo Gang Bo Gao Yan Jiang Wu-Guo Tian Dong-Lin Luo Department of Breast, Thyroid, and Vascular Surgery, Research Institute Daping Hospital, Third Military Medical University, Chongqing, 400042, P. R. China Correspondence to: Luo, email: LDL_dongDD@163.com Keywords: long non-coding RNA ANRIL, thyroid cancer, p15I NK4b TGF-β/Smad signaling pathway, TPC-1 Received: March 11, 2016 ...
B-box-containing (BBX) proteins play critical roles in a variety of cellular and developmental processes plants. BBX21 (also known as SALT TOLERANCE HOMOLOG2), which contains two B-box domains tandem at the N terminus, has been previously demonstrated key component involved COP1-HY5 signaling hub. However, exact molecular physiological are largely unclear. Here, we found that structurally disruption second domain, but not first one, completely abolishes its biological activity conferring...
Light-mediated seedling development is coordinately controlled by a variety of key regulators. Here, we identified two B-box (BBX)-containing proteins, BBX30 and BBX31, as repressors photomorphogenesis. ELONGATED HYPOCOTYL5, central regulator light signaling, directly binds to the G-box cis-element present in promoters BBX31 negatively controls their transcription levels light. Seedlings with mutations or are hypersensitive light, whereas overexpression leads hypo-photomorphogenic growth...
Light is one of the key environmental cues controlling photomorphogenic development in plants. A group B-box (BBX) proteins play critical roles this developmental process through diverse regulatory mechanisms. In study we report that BBX29 acts as a negative regulator light signaling. interacts with CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) and undergoes COP1-mediated degradation dark. Mutant seedlings loss function show shortened hypocotyls, while transgenic plants overexpressing display...
Phytochrome B (phyB) absorbs red light signals and subsequently initiates a set of molecular events in plant cells to promote photomorphogenesis. Here we show that phyB directly interacts with B-BOX CONTAINING PROTEIN 4 (BBX4), positive regulator signaling, positively controls its abundance light. BBX4 associates PHYTOCHROME INTERACTING FACTOR 3 (PIF3) represses PIF3 transcriptional activation activity PIF3-controlled gene expression. The degradation darkness is dependent on CONSTITUTIVELY...
Abstract Background MicroRNA 942-5p (miR-942-5p) has been reported to promote migration and invasion in non-small cell lung cancer (NSCLC), but the underlying mechanism is not completely understood. The interplay between long non-coding RNAs (lncRNAs) miRNAs plays a crucial role tumor progression. Methods In present study, we performed bioinformatic biochemical analyses identify miR-942-5p-interacting lncRNAs. function clinical significance of candidate lncRNA(s) NSCLC were determined....
<h3>Importance</h3> Physicians are required to work with rapidly growing amounts of medical data. Approximately 62% time per patient is devoted reviewing electronic health records (EHRs), clinical data review being the most time-consuming portion. <h3>Objective</h3> To determine whether an artificial intelligence (AI) system developed organize and display new referral would improve a clinician’s ability extract information compared current standard care. <h3>Design, Setting,...
This study explored teacher questioning as a formative assessment strategy by examining the practices of teachers English Foreign Language in Chinese tertiary institutions. It investigated how deployed questions to stimulate student thinking, uncover students’ current level learning, and allow responses inform pedagogic decisions. The research methods were classroom observations interviews. paper highlights practice one experienced who conducted quality gauge facilitate learning. provides...
CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) functions as an E3 ubiquitin ligase in both plants and animals. In dark-grown Arabidopsis thaliana seedlings, COP1 targets photomorphogenesis-promoting factors for degradation to repress photomorphogenesis. Little is known, however, about how itself regulated. Here, we identify SUPPRESSOR1 (CSU1), a RING-finger ligase, regulator of COP1. Genetic evidence demonstrates that csu1 mutations suppress cop1-6 phenotypes completely the dark. Furthermore, CSU1...
Abstract Numerous long noncoding RNAs (lncRNAs) are aberrantly expressed in pancreatic cancer (PC); however, their functions and mechanisms progression largely unknown. In this study, we identified a novel PC-associated lncRNA, RUNX1-IT1, that was significantly upregulated PC patient samples from multiple centers associated with poor prognosis. vitro vivo, alterations RUNX1-IT1 expression markedly affected proliferation, migration invasion. contributed to the of by interacting adjacent gene...
Phytophthora capsici is a broad-host range oomycete pathogen that can cause severe phytophthora blight disease of pepper and hundreds other plant species worldwide. Natural resistance against P. inadequate, it very difficult to control by most existing chemical fungicides. Therefore, urgent develop alternative strategies this pathogen. Recently, host-induced or spray-induced gene silencing essential virulent genes provided an effective strategy for controls. Here, we demonstrate effectively...