A5100705980- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Traditional Chinese Medicine Studies
- Cancer, Lipids, and Metabolism
- RNA Research and Splicing
- Tea Polyphenols and Effects
- Growth Hormone and Insulin-like Growth Factors
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Metabolism, Diabetes, and Cancer
- Ferroptosis and cancer prognosis
- Cancer Research and Treatments
- Cervical Cancer and HPV Research
- Traditional Chinese Medicine Analysis
- Microbial Metabolism and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Gut microbiota and health
- Angiogenesis and VEGF in Cancer
- Surgical site infection prevention
- Cytokine Signaling Pathways and Interactions
- Cancer-related gene regulation
- Physiological and biochemical adaptations
Affiliated Hospital of Guizhou Medical University
2020-2025
Guiyang Medical University
2020-2025
Jiangxi University of Traditional Chinese Medicine
2025
Jinzhong University
2024
Sixth Affiliated Hospital of Sun Yat-sen University
2019-2024
Sun Yat-sen University
2018-2024
China Medical University
2014-2024
Harbin Medical University
2014-2023
Hebei Medical University
2023
Second Hospital of Hebei Medical University
2023
Fubrick tea aqueous extract (FTEs) improved lipid metabolism by regulating gut microbiota and caffeine in high-fat diet induced obese mice.
Patients with peritoneal metastasis (PM) of colorectal cancer (CRC) have poorer overall survival outcomes than those without PM. Cancer-associated fibroblasts (CAFs) are a major component the tumor microenvironment and mediate CRC progression It is imperative to identify develop novel therapeutic targets for PM-CRC driven by CAFs. Using lipidomics, we reveal that abundance phosphatidylcholine (PC) unsaturated acyl chains was increased in clinical specimens. Additionally, found CAFs were...
Chemotherapy remains a major clinical option for the successful treatment of cancer by eliminating fast-growing populations cells. However, drug resistance causes failure antitumor treatment. Increasing evidence suggests that small subpopulation cells will enter "persister state" under pressure. The persister cell pool constitutes reservoir from which may emerge. Therefore, targeting presents therapeutic opportunity to prevent and impede tumor relapse. RT-qPCR, Western blot, Seahorse,...
Background and aim: Adenocarcinoma is a very common pathological subtype for lung cancer. We aimed to identify the gene signature associated with prognosis of smoking related adenocarcinoma using bioinformatics analysis. Methods: A total five expression profiles (GSE31210, GSE32863, GSE40791, GSE43458 GSE75037) have been identified from Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were analyzed GEO2R software functional pathway enrichment Furthermore, overall...
Estrogens are involved in the complex regulation of cell proliferation and apoptosis hormone sensitive tumors including breast endometrial cancers. Sulfation is main pathway for estrogen metabolism, which believed to be inactivation estrogens target tissues. SULT 1 E PAPSS ( 2) responsible sulfation by providing catalyzing enzyme universal sulfate donor. The present study showed expression patterns tissues tissue array analysis assessment clinical samples. enzymes were comparatively higher...
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). retracted at the request of Editor-in-Chief and authors. Panels from Figures 2C 2D appear similar to panels 4D 4F published by Hai-Xiang Yu, Xiao-Long Wang, Le-Ning Zhang, Ji Zhang Wei Zhao in Biomedicine & Pharmacotherapy 109 (2019) 751-761 https://doi.org/10.1016/j.biopha.2018.09.110. Figure 3B 3D previously Yuanyuan Meng, Qi Li,...
<b><i>Background/Aims: </i></b>To isolate key genes and pathways in renal cell carcinoma (RCC), which might reveal more evidences on the regulation network contribute to pathogenic mechanisms of RCC. <b><i>Methods: </i></b>Microarray data GSE34676, GSE23926 GSE48008 were downloaded from Gene Expression Omnibus. Differentially expressed (DEGs) differentially miRNAs respectively screened using Limma package, followed by selection CNV associated...
// Tao Li 1, * , Xiaoxia Liu 2, 3, Qin Shen 3 Wenjun Yang Zhenghao Huo Qilun 1 Haiyan Jiao Jing Chen Department of Oncology, General Hospital the Ningxia Medical University, Yinchuan 750004, China 2 Genetic and Cell Biology, Key Laboratory Fertility Preservation Maintenance (Ningxia University), Ministry Education, These authors contributed equally to this work Correspondence to: Chen, email: Chenjing1979@163.com Jiao, jiaohy65@163.com Keywords: gastric cancer, salinomycin, angiogenesis,...
Recent reports have shown that miR-145 concentration correlates with infarct size. In this paper, we attempt to predict heart failure and cardiovascular death after acute myocardial infarction using circulating concentration.We assessed 246 patients first ST-segment-elevation who underwent successful percutaneous coronary intervention. We measured miR-145, N-terminal fragment of the precursor B-type natriuretic peptide, myocardial-band creatine kinase, cardiac troponin-I concentrations on...
Abstract Background Most cancers favor glycolytic-based glucose metabolism. Hexokinase-2 (HK2), the first glycolytic rate-limiting enzyme, shows limited expression in normal adult tissues but is overexpressed many tumor tissues, including ovarian cancer. HK2 has been shown to be correlated with progression and chemoresistance of cancer could a therapeutic target. However, systemic toxicity inhibitors their clinical use. Since follicle-stimulating hormone (FSH) receptor (FSHR) not nonovarian...
Colorectal cancer (CRC) is presently a health challenge in China. Although clinical chemotherapy prescribed availably, the negative effects and poor prognoses still occur. Genistein has antitumor properties our previous studies. However, molecular mechanisms underlying anti-CRC of genistein remain unclear. Increasing evidences have indicated that induction autophagy, one cell death models, closely associated with formation development human cancer. In current study, systematic bioinformatics...
Colorectal cancer (CRC) is one of the top three malignant tumors in terms morbidity, and limited efficacy existing therapies urges discovery potential treatment strategies. Immunotherapy gradually becomes a promising method recent decades; however, less than 10% CRC patients could really benefit from immunotherapy. It pressing to explore combination therapy improve immunotherapy patients. reported that Farnesoid X receptor (FXR) deficiency associated with immunity. Herein, we found GW4064,...
Oncostatin M (OSM), a pleiotropic cytokine, has been shown to have distinctive effects in different tissues. In ovarian carcinoma, it is commonly co-expressed together with its receptors but precise role and the underlying molecular mechanism governing activity remains unclear. The aim of present study was investigate function recombinant human OSM (rH-OSM) cancer. demonstrated that rH-OSM promotes proliferation SKOV3 cancer cells. Western blot analysis showed phosphorylated-signal...
MicroRNAs (miRNAs) play essential roles in the development of COPD. In this study, we aimed to identify and validate potential miRNA biomarkers frequent non-frequent exacerbators COPD patients using bioinformatic analysis.The candidate were screened from Gene Expression Omnibus (GEO) dataset identified GEO2R online tool. Then, performed analyses including target prediction, gene ontology (GO), pathway enrichment analysis construction protein-protein interaction (PPI) network. Furthermore,...
The vascular endothelium is important in the physiological homeostasis of blood vessels. Increasing evidence demonstrates that oxidative stress‑induced endothelial damage involved pathogenesis several cardiovascular diseases, including atherosclerosis. Hyperoside, one major active components from Apocynum venetum L. (Luo‑Bu‑Ma), which a traditional Chinese herbal medicine commonly used for prevention exhibits diverse bioactivities, anti‑inflammatory and antioxidant effects. In present study,...