A5100340685- Endoplasmic Reticulum Stress and Disease
- Hippo pathway signaling and YAP/TAZ
- Microtubule and mitosis dynamics
- MicroRNA in disease regulation
- RNA modifications and cancer
- Plant Pathogens and Fungal Diseases
- Caveolin-1 and cellular processes
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Plant Disease Management Techniques
- melanin and skin pigmentation
- Pancreatic and Hepatic Oncology Research
- Ubiquitin and proteasome pathways
- Ferroptosis and cancer prognosis
- Plant-Microbe Interactions and Immunity
- Hemoglobin structure and function
- Proteoglycans and glycosaminoglycans research
- Genomics and Phylogenetic Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Glycosylation and Glycoproteins Research
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- Cancer Cells and Metastasis
- Lipid metabolism and biosynthesis
- Circular RNAs in diseases
Hunan Normal University
2023-2025
Henan Institute of Science and Technology
2024
Shanghai University of Traditional Chinese Medicine
2023-2024
Shanghai Jiao Tong University
2024
Xi'an Medical University
2023-2024
Shanghai Sixth People's Hospital
2024
Xi'an Jiaotong University
2017-2023
Hunan Provincial People's Hospital
2023
North China University of Science and Technology
2023
Qingdao University
2023
With the rapid advancements in computer vision, using deep learning for strawberry disease recognition has emerged as a new trend. However, traditional identification methods heavily rely on manual discernment, consuming valuable time and imposing significant financial losses growers. To address these challenges, this paper presents BerryNet-Lite, lightweight network designed precise identification. First, comprehensive dataset, encompassing various diseases at different maturity levels, is...
The kinesin family member C1 (KIFC1, also known as HSET) is a superfamily protein (KIFs). Although KIFC1 acts crucial role in the development of several human cancers, expression profile and functional remain unclear non-small cell lung cancer (NSCLC).We collected fresh NSCLC samples paired normal tissue patients with operation, detected using quantitative reverse-transcription polymerase chain reaction (qRT-PCR) Western blotting. To expand on previous smaller-scale studies, microarrays...
Rab14 is a member of RAS oncogene family, and its dysfunction has been reported to be involved in various types human cancer. However, expression function were still unclear gastric The aim this study was investigate the mechanism cancer cell lines. Quantitative real-time PCR (qRT-PCR) performed 17 adenocarcinoma tissues 4 lines detect Rab14. 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT), colony formation flow cytometry assays employed determine proliferative ability,...
Endoplasmic reticulum (ER) stress has been implicated in the pathophysiology of various pulmonary diseases via activation unfolded protein response. However, role ER arterial hypertension (PAH) remains unclear. The well-known chemical chaperone 4-phenylbutyric acid (4-PBA) inhibits signaling. We hypothesized that known chaperones, including 4-PBA, would inhibit and prevent and/or reverse PAH.
MicroRNAs (miRNAs) have been demonstrated to be critical in regulating tumor development and progression. The present study investigated the expression of miR‑588 using reverse transcription‑quantitative polymerase chain reaction analysis 85 cases lung squamous cell carcinoma (SCC), observed correlation between with clinical pathologic features. results indicated that was predominantly lower samples, compared non‑tumorous negatively associated stages lymph node invasion. also examined...
This study investigated the effect of methyl-CpG-binding protein 2 (MeCP2) on miRNA transcription. Our results chip assay and ChIP-seq showed that MeCP2 inhibited expressions numerous miRNAs by binding to their upstream elements, including not only promoter but also distal enhancer. Among affected miRNAs, miR-22 was identified remarkably suppress gastric cancer (GC) cell proliferation, arrest G1-S cycle transition, induce apoptosis targeting MeCP2, MTHFD2, MTHFR. Understanding GC metabolism...
Objective The aim of this study was to identify the expression miRNA and lymphocyte subsets in blood gastric cancer (GC) patients, elucidate their clinical significance GC, establish novel biomarkers for early diagnosis prognosis GC. Methods miRNAs serum GC patients screened using second-generation sequencing detected qRT-PCR. correlation between clinicopathological characteristics analyzed, molecular markers predicting were identified. Additionally, flow cytometry used detect proportion...
Numerous xenobiotics, including therapeutics agents, are substrates for bioactivation to electrophilic reactive intermediates that may covalently modify biomolecules. Selective estrogen receptor modulators (SERMs) in clinical use long-term therapy of postmenopausal syndromes and chemoprevention provide a potential alternative hormone replacement (HRT). Raloxifene, common with many SERMs other is polyaromatic phenol has been shown be metabolically bioactivated redox active quinoids. Nucleic...
Although Neurexins, which are cell adhesion molecules localized predominantly to the presynaptic terminals, known regulate synapse formation and synaptic transmission, their roles in regulation of vesicle release during repetitive nerve stimulation unknown. Here, we show that nrx mutant synapses exhibit rapid short term depression upon tetanic stimulation. Moreover, demonstrate intracellular region NRX is essential for Using a yeast two-hybrid screen, find interacts with...
Polysaccharides from wampee have been reported to process various biological activities, while the relationship between structure and bioactivities has barely addressed. Pectin, an abundant water-soluble polysaccharide in wampee, showed significant antioxidant activity, which was associated with anti-melanogenic activity. Therefore, this study investigated physicochemical characteristics anti-melanogenesis effect of pectin extracted fruit A375 cells.The characterization by gel chromatography...
Liver cancer is a serious global health problem and associated with poor spiritual health. Bibliotherapy beneficial in improving outcomes patients, yet there lack of empirical evidence its effect on the liver patients China. The study aimed to investigate effects bibliotherapy based Chinese traditional culture This was approved by Ethics Committee Hunan Normal University School Medicine registered Clinical Trial Registry registration (No: 2021260), which June 30th 2021.A total 60 were...
Abstract Background Numerous factors influence the growth and development of cashmere. Existing research on cashmere has predominantly emphasized a single omics level. Integrating multi-omics analyses can offer more comprehensive understanding by encompassing entire spectrum. This study accurately comprehensively identified key influencing fineness using analysis. Methods used skin tissues coarse type (CT_LCG) fine Liaoning goats (FT_LCG) for employed an integrated approach involving...
Abstract Myogenic differentiation 1 (MyoD1) is a transcription factor that promotes expression of muscle-specific genes. MyoD1 expressed at significantly lower levels in gastric cancer (GC) tissues and cells, it induces apoptosis GC cells. However, functions for cell migration gene have not been documented. We show knockdown promoted invasion whereas overexpression suppressed invasion. performed chromatin immunoprecipitation (ChIP)-sequencing to identify target genes MKN-45 The 2-kb upstream...
Transient receptor potential melastatin 8 (TRPM8) modulates tumor biology and sensitivity to treatment. The present study aimed determine the part it plays in immunity physiology using pan-cancer analysis.Data from GTEx, CCLE, TISIDB, GSCA, cBioportal, TCGA databases were collected Estimate, Scanneo, GSEA, associations between TRPM8 prognosis, molecular subtypes, mutational burden, microsatellite instability, immune gene functions, drug analyzed 33 types.TRPM8 levels found be elevated most...
Hu-antigen R (HuR) is involved in the carcinogenesis and progression of multiple types cancer. However, its precise role gastric cancer (GC) relevant molecular mechanism remain largely unclear. In present study, we found that HuR expression level was higher GC tissues cell lines than adjacent normal epithelial lines, this elevated to have a significant association with lymph node metastasis. Moreover, silencing RNA interference inhibited viability induced apoptosis through apoptosis-related...
Cell division cycle-associated 2 (CDCA2) plays an important role in regulating chromosome structure during mitosis. It is highly expressed oral squamous cell carcinoma, neuroblastoma and lung adenocarcinoma, its upregulation positively associated with tumor progression. However, the expression, biological function underlying mechanisms of CDCA2 clear renal carcinoma (ccRCC) remain poorly understood. In present study, was demonstrated to be upregulated ccRCC tissues compared normal kidney...
Abstract Background Gestational diabetes mellitus is a risk factor for congenital heart defects. The article aimed to investigate the expression and roles of MST1, YAP1, Last1/2 Survivin in modulating HG-induced cardiomyocyte apoptosis maternal diabetes-induced abnormality. Methods Diabetes was induced rats using streptozotocin. protein phosphorylation analysis fetal tissue assessed by western blot immunohistochemical staining. Hoechst 33342 staining assay performed explore H9C2 apoptosis....