A5100630068- Circular RNAs in diseases
- Clinical Nutrition and Gastroenterology
- MicroRNA in disease regulation
- Nutrition and Health in Aging
- Sepsis Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- Acute Ischemic Stroke Management
- Advanced Glycation End Products research
- Blockchain Technology Applications and Security
- Redox biology and oxidative stress
- Cancer Research and Treatments
- Enhanced Recovery After Surgery
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- Nanoplatforms for cancer theranostics
- Pluripotent Stem Cells Research
- Renal and related cancers
- Pneumonia and Respiratory Infections
- Hippo pathway signaling and YAP/TAZ
- Anesthesia and Neurotoxicity Research
- Virus-based gene therapy research
- Sirtuins and Resveratrol in Medicine
- Wnt/β-catenin signaling in development and cancer
- Cancer Mechanisms and Therapy
- Urological Disorders and Treatments
First Hospital of Jilin University
2017-2024
Jilin University
2017-2024
China Communications Construction Company (China)
2024
Chongqing Medical University
2024
Children's Hospital of Chongqing Medical University
2024
Beijing Jiaotong University
2023
Cangzhou Central Hospital
2022
Liaoning Shihua University
2022
Shandong First Medical University
2019-2021
Jining First People's Hospital
2020
Forced expression of selected transcription factors can transform somatic cells into embryonic stem cell (ESC)-like cells, termed induced pluripotent (iPSCs). There is no consensus regarding the preferred tissue from which to harvest donor for reprogramming iPSCs, and some types may be more prone than others accumulation epigenetic imprints mutations. Here, we present a simple, reproducible, noninvasive method generating human iPSCs renal tubular in urine. This procedure eliminates many...
Abstract Aberrant regulation in mesangial cell proliferation, extracellular matrix (ECM) accumulation, oxidative stress, and inflammation under hyperglycemic condition contributes significantly to the occurrence development of diabetic nephropathy (DN). However, mechanisms underlying hyperglycemia‐induced dysregulations have not been clearly elucidated. Here, we reported that high mobility group box 1 (HMGB1) was highly elevated glucose (HG)‐treated cells, induced phosphorylation, nuclear...
Abstract BACKGROUND : Although the prevalence of oral clefts in China is among highest countries worldwide, little known about its descriptive epidemiology. METHODS Data used this study were collected from 1996 to 2005 using nationwide hospital‐based registry, Chinese Birth Defects Monitoring Network. A total 4,891,472 newborns (live or still births with 28 weeks gestation more) delivered member hospitals assessed for birth defects within 7 days following birth. RESULTS The nonsyndromic,...
Papillary thyroid cancer (PTC) is a common malignancy in endocrine system worldwide. Increasing evidence has shown that dysregulation of circular RNAs (circRNAs) could contribute to PTC tumorigenesis. The aims this project are investigate the potential role and molecular mechanism hsa_circ_0039411 PTC. In project, RT-qPCR was performed measure expression profile tissues cells. Cell counting kit-8, clonogenic, flow cytometric, transwell experiments were used identify biological on cell...
Abstract Background DNA‐Dependent Protein Kinase Catalytic Subunit ( PRKDC ), a key component of the DNA damage repair pathway, is associated with chemotherapy resistance and tumor progression. Methods Here we analyzed transcriptome data ~2,000 breast cancer patients performed functional studies in vitro to investigate function cancer. Results Our results revealed overexpression multiple subtypes. Consistent patients’ data, was also observed cell lines compared normal epithelial cells....
Background/Aims: We sought to assess a consecutive number of patients with first-ever acute ischemic stroke (AIS), the clinical relevance in regard functional outcome serum uric acid (SUA) measured at admission. Methods: In 2 prospective centers for observational study, concentrations SUA were on admission 710 AIS. determined by high-performance liquid chromatography. SUA, NIH scale (NIHSS), and conventional risk factors evaluated determine their value predict within 3 months. Results:...
Glioma is the most common type of primary intracranial tumor. Dysregulation circular RNAs (circRNAs) plays a critical role in multiple solid tumors. However, expression profiles circRNAs and their functions glioma have been rarely studied. The current work aims to investigate clinical significance novel circRNA, circ-POSTN, explore its biological mechanisms progression glioma. We found that circ-POSTN was highly expressed tissue samples cells. High significantly linked larger tumor size,...
Abstract Atherosclerosis is one of the most common and crucial heart diseases involving brain. At present, atherosclerosis its major complications comprise leading causes death worldwide. Our purpose was to identify role ciRS‐7 in atherosclerosis. Tubulogenesis HMEC‐1 cell evaluated utilizing tube formation assay. Cell Counting Kit‐8 assay flow cytometry were utilized test viability apoptosis. Migration determine migration capacity experimental cells. Western blot applied examine apoptosis...
This study aims to investigate the relationship between blood-based pathologies and established risk factors for cognitive decline in community-based population of Chongqing, a region with significant aging. A total 26,554 residents aged 50 years older were recruited. Multinomial logistic regression models applied assess cognition levels. Propensity score matching linear mixed effects used evaluate key circulating biomarkers. Shared distinct MCI dementia identified. Age, lower education,...
Altered microRNA (miRNA/miR) expression regulates tumor development and progression in triple‑negative breast cancer (TNBC). The present study examined the effect of miR‑27a on proliferation, migration invasion TNBC cells vitro vivo. An MTT assay was performed to examine proliferation MDA‑MB‑231 MDA‑MB‑468 with either overexpression or downregulation miR‑27a, presence absence radiation. migratory invasive abilities were assessed by Transwell Matrigel assays. protein levels western blotting....
The gene solute carrier family 34 (sodium phosphate), member 2 ( SLC34A2 ), is a of the SLC34 family. Increasing evidence suggests that involved in development many human carcinomas. However, its role hepatocellular carcinoma (HCC) still unclear. Therefore, this study we investigated HCC and explored underlying mechanism. We found expression upregulated cell lines. Knockdown obviously inhibited proliferation, migration/invasion, epithelial‐mesenchymal transition (EMT) phenotype. Furthermore,...
This prospective study compared clinical characteristics and prognosis between primary (P) secondary (S) acute gastrointestinal injury (AGI) (P-AGI)/(S-AGI) in critically ill patients. was a prospective, single-center observational study. Patients were included if they had been hospitalized for at least 72 h before the AGI diagnosis. classified according to severity of dysfunction, while P-AGI or S-AGI defined whether system directly indirectly involved. Clinical characteristics, Acute...
To assess the functional significance of tethering actin to myosin by caldesmon in regulation smooth muscle contraction, we investigated effects synthetic peptides, containing myosin-binding sequences N-terminal region caldesmon, on force directly recorded from single permeabilized cells ferret portal vein. Two peptides were used, IK29C and MY27C, residues Ile<sup>25</sup> Lys<sup>53</sup> Met<sup>1</sup> Tyr<sup>27</sup> human chicken sequence, respectively, plus an added cysteine at C...
Abstract The present study aimed to investigate the regulatory roles of microRNA-451 (miR-451) on inflammation and proliferation glomerular mesangial cells (GMCs) under high-glucose condition, reveal potential mechanisms related 26S proteasome non-ATPase subunit 11 (PSMD11) nuclear factor-κ B (NF-κB) signaling. interaction between PSMD11 miR-451 was identified by dual luciferase reporter (DLR) gene assay. GMCs were treated with 5.6 mmol/l (normal, L-GMCs) 30 glucose (high-glucose, H-GMCs),...
Abstract This study aimed to explore the changes of pharmacokinetic parameters after meropenem in patients with abdominal septic shock gastrointestinal perforation, and simulate probability different dosing regimens achieving pharmacodynamic goals. The included 12 patients, utilized high performance liquid chromatography-tandem mass spectrometry monitor plasma concentration meropenem. target attainment (PTA) for minimum inhibitory (MIC) values %fT > 4MIC was compared among simulated...
Objective To evaluate and explore the feasibility of using quality control indicators for nutritional therapy in critically ill patients as evaluation criteria. Methods This study focused on intensive care unit (ICU) conducted a cross-sectional investigation (the proportion with application enteral nutrition pump, risk assessment rate, start within 48 hours, caloric protein target achievement rate 7th day) 13 hospitals Jilin Province. After training according to critical related guidelines...
Abstract Background Gestational diabetes mellitus is a risk factor for congenital heart defects. The article aimed to investigate the expression and roles of MST1, YAP1, Last1/2 Survivin in modulating HG-induced cardiomyocyte apoptosis maternal diabetes-induced abnormality. Methods Diabetes was induced rats using streptozotocin. protein phosphorylation analysis fetal tissue assessed by western blot immunohistochemical staining. Hoechst 33342 staining assay performed explore H9C2 apoptosis....