A5103103052- Microtubule and mitosis dynamics
- Ocular Oncology and Treatments
- Facial Trauma and Fracture Management
- Ophthalmology and Eye Disorders
- Cancer-related Molecular Pathways
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Traumatic Ocular and Foreign Body Injuries
- Mesenchymal stem cell research
- Traumatic Brain Injury and Neurovascular Disturbances
- Ocular Surface and Contact Lens
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- Liver physiology and pathology
- Nanoparticle-Based Drug Delivery
- Wound Healing and Treatments
- Glaucoma and retinal disorders
- Plant nutrient uptake and metabolism
- Corneal Surgery and Treatments
- Wnt/β-catenin signaling in development and cancer
- Dendrimers and Hyperbranched Polymers
- Chemokine receptors and signaling
- Pluripotent Stem Cells Research
- Cerebral Venous Sinus Thrombosis
- Ocular Infections and Treatments
Daping Hospital
2012-2022
Army Medical University
2012-2022
University of Southern California
2019
Academy of Military Medical Sciences
2006-2007
Abstract Islet cell replacement is considered as the optimal treatment for type I diabetes. However, availability of human pancreatic islets transplantation limited. Here, we show that bone marrow‐derived mesenchymal stem cells (hMSCs) could be induced to differentiate into functional insulin‐producing by introduction duodenal homeobox‐1 (PDX‐1). Recombinant adenoviral vector was used deliver PDX‐1 gene hMSCs. After being infected with Ad‐PDX‐1, hMSCs were successfully insulin‐secreting...
The high incidence rate of hepatocellular carcinoma (HCC) is mainly the result frequent metastasis and tumor recurrence. Unfortunately, underlying molecular mechanisms driving HCC are still not fully understood. It has been demonstrated that stroma cells contribute to primary growth metastasis. Within environment, activated hepatic stellate (HSCs) can release a number molecules enhance cancer cell proliferation invasiveness in paracrine manner. Here, for first time, we demonstrate epimorphin...
Chronic inflammation-induced metastases have long been regarded as one of the significant obstacles in treating cancer. Tumor necrosis factor-α (TNF-α), a main inflammation mediator within tumor microenvironment, affects development by inducing multiple chemokines to establish complex network. Recent reports revealed that CXCL10/CXCR3 axis cancer cells invasiveness and metastases, Epithelial-mesenchymal transition (EMT) is reason for frequent proliferation distant organ colon (CC) cells,...
SPINDLIN1, a new member of the SPIN/SSTY gene family, was first identified as highly expressed in ovarian cancer cells. We have previously shown that it is involved process spindle organization and chromosomal stability plays role development cancer. Nevertheless, mechanisms underlying its oncogenic are still largely unknown. Here, we showed expression SPINDLIN1 upregulated clinical tumors. Ectopic promoted cell proliferation activated WNT/T-cell factor (TCF)-4 signaling. The Ser84 Ser99...
The intraorbital wooden foreign body is often misdiagnosed or missed on computed tomog- raphy (CT) scan, due to the invisible unclear images. residual bodies occur during surgical removal. clinical manifestations, imaging features and treatment of were discussed in this study.We retrospectively analyzed 14 cases managed at our hospital between January 2007 May 2015. All patients underwent orbital CT examination before surgery, surgery was performed under general anesthesia with wound...
Abstract Spin/Ssty gene family is high conserved and very abundant transcript involved in gametogenesis, which was repeatedly detected early embryo. Nevertheless, the biologic roles of members are still largely unknown. Previously we have identified human spindlin1 as a homologue from ovarian cancer cells, reported that stable overexpression could transform NIH3T3 cells induce tumorigenesis nude mouse. Here, showed spindlin1, nuclear protein, relocated during mitosis. A fraction proteins...
Thyroid associated ophthalmopathy (TAO), characterized by T cell infiltration and orbital fibroblast activation, is an organ-specific autoimmune disease which still short of effective safety therapeutic drugs. The PD-1/PD-L1 pathway has been reported hindering the progression Graves’ to some extent inhibiting activity, tumor therapy with a PD-1 inhibitor caused adverse effects similar symptoms TAO. These findings suggest that may be pathogenesis However, it remains unknown whether involved...
Epimorphin/syntaxin 2 is a high conserved and very abundant protein involved in epithelial morphogenesis various organs. We have shown recently that epimorphin (EPM), exclusively expressed on the surface of hepatic stellate cells myofibroblasts liver, induces bile duct formation stem-like (WB-F344 cells) putative biophysical way. Therefore, aim this study was to present some molecular mechanisms by which EPM mediates formation. established biliary differentiation model co-culture...
Bi-potential hepatic progenitor cells can give rise to both hepatocytes and cholangiocytes, which is the last phase critical juncture in terms of sequentially lineage restriction from any kind stem cells. If their differentiation be controlled, it might access functional develop pharmaceutical biotechnology industries as well cell therapies for end-stage liver diseases.In this study, we investigated influence Cx32 Cx43 on hepatocyte WB-F344 by vitro gain loss function analyses. An inhibitor...
The expression of CD24 has been detected in a wide variety human malignancies. Downregulation inhibits proliferation and induces apoptosis tumor cells, whereas its upregulation increases growth metastasis. However, no data on protein levels retinoblastoma are available, the mechanism involvement progress not elucidated. aim this study was to explore profile samples correlate with clinicopathological parameters.Immunohistochemistry performed for archival paraffin sections correlated features....
To investigate the risk factors of retinoblastoma in Chongqing and offer bases for scientific measures.One hundred thirty-three patients were taken as case group, 133 children control group 1:1 ratio. The relevant collected from a questionnaire survey which was made by our research group. First, Chi-square t-test used to discuss various factors, then logistic regression analysis statistics software SPSS17.0 based on result 266 people.Single factor results showed differences between two...
We aimed to evaluate the effect of inferior rectus muscle thickening on intraocular pressure (IOP) in patients with thyroid-associated ophthalmopathy (TAO).We analyzed 33 TAO (50 eyes) who presented hypotropia primary position. There was significant eyeball movement restriction and confirmed computed tomography or magnetic resonance imaging. measured IOP changes normal participants position upgaze using Icare tonometer. Moreover, we preoperative postoperative 13 underwent recession.The...
<b><i>Purpose:</i></b> This study was aimed to investigate the safety and feasibility of umbilical cord-derived mesenchymal stem cell (MSC) transplantation in patients with traumatic optic neuropathy (TON). <b><i>Methods:</i></b> is a single-center, prospective, open-labeled phase 1 that enrolled 20 TON. Patients consecutively underwent either canal decompression combined MSC local implantation treatment (group 1) or only 2). were evaluated on...
The endoscopic transethmoidal approach is favored for the lack of external scars, a wide field view, and rapid recovery time. But effect iatrogenic trauma should not be ignored due to removal uncinate process anterior posterior ethmoidal sinus. Anatomically, optic nerve close sphenoid sinus Onodi cell. In order preserve sinus, we perform transsphenoidal canal decompression (ETOCD), which less invasive. However, anatomy quite variable, anatomical landmarks are rare. Therefore, identifying...