A5101848938- Gut microbiota and health
- Probiotics and Fermented Foods
- Helicobacter pylori-related gastroenterology studies
- Digestive system and related health
- Infant Nutrition and Health
- NF-κB Signaling Pathways
- Cytokine Signaling Pathways and Interactions
- Berberine and alkaloids research
- Inflammatory Bowel Disease
- Cancer Research and Treatments
- Phytochemical Studies and Bioactivities
- Immune Response and Inflammation
- Gastrointestinal motility and disorders
- Glycosylation and Glycoproteins Research
- Colorectal Cancer Treatments and Studies
- Cell death mechanisms and regulation
- Inflammatory mediators and NSAID effects
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Plant-based Medicinal Research
- Epigenetics and DNA Methylation
- Microtubule and mitosis dynamics
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related Molecular Pathways
Jilin Agricultural University
2025
Vanderbilt University Medical Center
2015-2024
Vanderbilt University
2008-2024
Guizhou University
2024
Guizhou Provincial People's Hospital
2020-2024
Guiyang Medical University
2020-2024
China Pharmaceutical University
2022
Monroe Carell Jr. Children's Hospital
2010-2020
Hebei Medical University
2020
Second Hospital of Hebei Medical University
2020
Probiotic bacteria are microorganisms that benefit the host by preventing or ameliorating disease. However, little information is known regarding scientific rationale for using probiotics as alternative medicine. The purpose of this paper to investigate mechanisms probiotic beneficial effects on intestinal cell homeostasis. We now report one such probiotic,<i>Lactobacillus rhamnosus</i> GG (LGG), prevents cytokine-induced apoptosis in two different epithelial models. Culture LGG with either...
Probiotics promote intestinal epithelial integrity and reduce infection diarrhea. We evaluated the effect of Lactobacillus rhamnosus GG-produced soluble proteins (p40 p75) on hydrogen peroxide-induced disruption tight junctions barrier function in Caco-2 cell monolayers. Pretreatment monolayers with p40 or p75 attenuated decrease transepithelial resistance increase inulin permeability a time- dose-dependent manner. also prevented redistribution occludin, ZO-1, E-cadherin, beta-catenin from...
Probiotic bacteria can potentially have beneficial effects on the clinical course of several intestinal disorders, but our understanding probiotic action is limited. We identified a bacteria-derived soluble protein, p40, from Lactobacillus rhamnosus GG (LGG), which prevents cytokine-induced apoptosis in epithelial cells. In current study, we analyzed mechanisms by p40 regulates cellular responses cells and p40's experimental colitis using mouse models. show that recombinant protein activated...
Chronic constipation is a prevalent functional gastrointestinal disorder accompanied with intestinal dysbiosis. However, causal relationship between dysbiosis and remains poorly understood. Serotonin transporter (SERT) transmembrane transport protein which re-uptakes excessive 5-hydroxytryptamine (5-HT) from effective location to terminate its physiological effects involves in regulating motility. In this study, fecal microbiota patients healthy controls were transplanted into the antibiotic...
The gut microbiota plays an important role in maintaining intestinal homeostasis. Dysbiosis is associated with tumorigenesis. Deoxycholic acid (DCA), a secondary bile increased by western diet, correlates carcinogenesis. However, evidence relating acids, and tumorigenesis are limited. In our study, we investigated the effect of DCA on induction dysbiosis its roles Alteration composition was induced DCA-treated APCmin/+ mice, which accompanied impaired barrier, low grade inflammation tumor...
Inflammatory bowel disease (IBD) results from dysregulation of intestinal mucosal immune responses to microflora in genetically susceptible hosts. A major challenge for IBD research is develop new strategies treating this disease. Berberine, an alkaloid derived plants, alternative medicine bacterial diarrhea and parasite infections. Recent studies suggest that berberine exerts several other beneficial effects, including inducing anti-inflammatory responses. This study determined the effect...
p40, a Lactobacillus rhamnosus GG (LGG)-derived protein, transactivates epidermal growth factor receptor (EGFR) in intestinal epithelial cells, leading to amelioration of injury and inflammation. To elucidate mechanisms by which p40 regulates mucosal immunity prevent inflammation, this study aimed determine the effects on regulation proliferation-inducing ligand (APRIL) expression cells for promoting immunoglobulin A (IgA) production. upregulated April gene protein production mouse small...
Berberine, an isoquinoline alkaloid derived from plants, is a traditional medicine for treating bacterial diarrhea and intestinal parasite infections. Although berberine has recently been shown to suppress growth of several tumor cell lines, information regarding the effect on colon limited. Here, we investigated mechanisms underlying effects regulating fate cells, specifically mouse immorto-Min colonic epithelial (IMCE) cells carrying Apcmin mutation, normal namely young adult epithelium...
Observational evidence suggests that human milk oligosaccharides (HMOs) promote the growth of commensal bacteria in early life and adulthood. However, mechanisms by which HMOs benefit health through modulation gut microbial homeostasis remain largely unknown. 2'-fucosyllactose (2'-FL) is most abundant oligosaccharide contributes to essential benefits associated with consumption. Here, we investigated how 2'-FL prevents colitis adulthood its effects on community. We found microbiota from...
Purpose of review Recent evidence has shown that commensal bacteria regulate intestinal physiology, development, and function. This focuses on new insights into the effects these organisms health disease. findings Gastrointestinal tract development function is determined by communication between epithelium bacteria. Important regulatory interactions cells are being defined with early indicating both beneficial harmful consequences to host. A subgroup overlaps probiotic have preventative...
Helicobacter pylori is the strongest identified risk factor for gastric adenocarcinoma. One H. virulence constituent that augments cancer cag secretion system, which translocates CagA and peptidoglycan into host cells, eventuating in activation of signal transduction pathways. AKT a target phosphatidylinositol 3-kinase (PI3K) activated cancer, but relationship between PI3K-AKT pylori-induced cellular responses with carcinogenic potential remains unclear. We defined molecular pathways...
The genomes of <i>Lactobacillus casei/paracasei </i>and rhamnosus</i> strains carry two genes encoding homologues p40 and p75 from <i>L. GG, secreted proteins which display anti-apoptotic cell protective effects on human intestinal epithelial cells. cysteine, histidine-dependent aminohydrolase/peptidase (CHAP) NLPC/P60 domains, respectively, are characteristic with cell-wall hydrolase activity. In casei</i> BL23 both were to the growth medium also located at...
Hybrid hydrogels from biopolymers have been applied for various indications across a wide range of biomedical, pharmaceutical, and functional food industries. In particular, hybrid synthesized two attracted increasing attention. The inclusion second biopolymer strengthens the stability resultant enriches its functionalities by bringing in new groups or optimizing micro-environmental conditions certain biological biochemical processes. This article presents approaches that used our to...