A5060065405- Animal health and immunology
- Reproductive System and Pregnancy
- Infant Nutrition and Health
- Gut microbiota and health
- Diet and metabolism studies
- Digestive system and related health
- Reproductive Physiology in Livestock
- Biochemical Analysis and Sensing Techniques
- Identification and Quantification in Food
- Mass Spectrometry Techniques and Applications
- Reproductive Biology and Fertility
- Sensory Analysis and Statistical Methods
- Advanced Proteomics Techniques and Applications
- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Probiotics and Fermented Foods
- Helicobacter pylori-related gastroenterology studies
- Olfactory and Sensory Function Studies
- Biochemical effects in animals
Vanderbilt University Medical Center
2022-2024
New York State College of Agriculture & Life Sciences
2020-2023
Cornell University
2020-2023
Observational evidence suggests that human milk oligosaccharides (HMOs) promote the growth of commensal bacteria in early life and adulthood. However, mechanisms by which HMOs benefit health through modulation gut microbial homeostasis remain largely unknown. 2'-fucosyllactose (2'-FL) is most abundant oligosaccharide contributes to essential benefits associated with consumption. Here, we investigated how 2'-FL prevents colitis adulthood its effects on community. We found microbiota from...
Consumption of the milk fat globule membrane (MFGM) by infants is linked to enhanced neurodevelopment and sustained cognitive improvements later in life. Aging, contrast, often marked neurodegeneration decline- a growing concern U.S. as 6.9 million Americans live with Alzheimers disease (AD). As such, identifying interventions prevent impairment are imperative. The whey protein phospholipid concentrate (WPPC), dairy co-product, enriched MFGM glycoconjugates. Given health benefits conferred...
Whey protein phospholipid concentrate (WPPC), a byproduct of whey processing, is high in phospholipids and glycoconjugates which serve as substrates for fatty acids sugar monomers (e.g. sialic acid) critical to neuronal myelin synthesis the brain. This led us hypothesize that WPPC will improve cognitive impairment induced by fat (HF) diet promoting turnover improving myelin-dependent processes associated with encoding storing memory. Male Wistar rats were randomized one four diets starting...
Neonatal calf survival and health is predominantly dependent on sufficient consumption of immunoglobulin G (IgG) the resulting transfer passive immunity (TPI). In this study, we investigate potential for continued IgG secretion temporal kinetics mammary output in sequential milkings performed at 0, 4, 16, 28, 40, 52 hr postcalving Holstein dairy cows. For colostrum (0 hr), also scrutinize relationships between concentration, volume, refractometer readings (˚Bx values, Brix) concentration...
Serum-based biomarkers hold propitious applications for addressing livestock health, and management. However, discovery of protein in complex biological fluids like serum is wholly intractable due to the large dynamic range concentrations; that is, ˜10-12 high abundance proteins constitute >90% total content effectively mask proteomic detection low-abundance biomarkers. Toward this limitation, we test a continuous elution size-based fractionation method, two approaches use affinity...
Journal Article Contradictions on colostrum IgG levels and Brix values are real can be explained. Response to letter by Lombard et al. (2022) Get access Kasey M Schalich, Schalich Department of Animal Science, College Agriculture Life Sciences, Cornell University, Ithaca, NY 14853, USADepartment Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA https://orcid.org/0000-0001-6838-3755 Search for other works this author on: Oxford Academic PubMed Google Scholar Vimal...
Introduction Intestinal epithelial cells (IECs) provide the frontline responses to gut microbiota for maintaining intestinal homeostasis. Our previous work revealed that IEC-derived components promote beneficial effects of a commensal and probiotic bacterium, Lactobacillus rhamnosus GG (LGG). This study aimed elucidate regulatory on LGG at molecular level. Methods Differential gene expression in cultured with timepoint between exponential stationary phase was studied by RNA sequencing...
Conserved in female reproduction across all mammalian species is the estrous cycle and its regulation by hypothalamic-pituitary-gonadal (HPG) axis, a collective of intersected hormonal events that are crucial for ensuring uterine fertility. Nonetheless, knowledge direct mediators synchronously shape microenvironment successive yet distinct events, such as transit sperm support progressive stages preimplantation embryo development, remain principally deficient. Toward understanding timed...
Consumption of ultrapasteurized milk is marked by extensive global variability; in the U.S. and U.K., less than 10% fluid marketed as ultrapasteurized, compared to >80% France, Spain Portugal. Fluid taste perception amongst consumers that high-heat treatment milk, ultrapasteurization, generates undesirable differences low-temperature/conventional pasteurized treatment. Although highly trained experts can distinguish characteristics controlled studies, it remains unknown if general detect...
Abstract Maternal-offspring coevolution has introduced the biological concept of “neonatal programming,” in which soluble proteins varying abundance bovine colostrum can have targeted activities calf gut. Still, identities and developmental programming mechanisms full profile on transiently expressed gut receptors/transporters, as well ultimate functional responses calf, remain to be completely elucidated. The objective this study was address gap knowledge using systems biology. First, we...