A5008420358- Mesenchymal stem cell research
- Wound Healing and Treatments
- Acupuncture Treatment Research Studies
- Healthcare and Venom Research
- PI3K/AKT/mTOR signaling in cancer
- Hemostasis and retained surgical items
- TGF-β signaling in diseases
- Ubiquitin and proteasome pathways
- Sirtuins and Resveratrol in Medicine
- MicroRNA in disease regulation
- Electrospun Nanofibers in Biomedical Applications
- Immune Response and Inflammation
- Advanced Chemical Physics Studies
- Natural product bioactivities and synthesis
- Infant Health and Development
- 14-3-3 protein interactions
- Neonatal Respiratory Health Research
- Inflammation biomarkers and pathways
- Hedgehog Signaling Pathway Studies
- Connective Tissue Growth Factor Research
- Pharmacological Effects of Natural Compounds
- Phagocytosis and Immune Regulation
- Diabetic Foot Ulcer Assessment and Management
- Surgical Sutures and Adhesives
- Histone Deacetylase Inhibitors Research
Hunan University of Traditional Chinese Medicine
2025
Army Medical University
2010-2024
Daping Hospital
2008-2024
Jiangnan University
2023
Wuxi Fourth People's Hospital
2023
Guangdong Institute for Drug Control
2023
Fudan University
2005-2022
Huashan Hospital
2020-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2022
Peking Union Medical College Hospital
2015-2022
Stromal cell-derived factor-1 (SDF-1) is a potent chemokine for bone marrow-derived stromal stem cells (BMSCs) that express CXCR4, the receptor SDF-1. SDF-1 considered to play an important role in trafficking of BMSCs. We investigated contribution recruitment BMSCs wound area and its promotion repair neovascularization. were pretreated with or without anti-CXCR4 blocking antibody combined CM-DiI label, injected via tail vein into mice full-thickness skin wounds on dorsum. Simultaneously,...
Capsaicin is the major pungent ingredient in red peppers which world widely consumed.Except its potent pain relieving efficacy as reported, capsaicin also exerted antitumor activity several tumor models.Here, we reported that had a profound anti-proliferative effect on human colon cancer cells via inducing cell cycle G0/G1 phase arrest and apoptosis, was associated with an increase of p21, Bax cleaved PARP.The underlying mechanism capsaicin's potency mainly attributed to stabilization...
Metabolic reprogramming endows cancer cells with the ability to adjust metabolic pathways support heterogeneously biological processes. However, it is not known how reprogrammed activities are implemented during differentiation of stem (CSCs). In this study, we demonstrated that liver CSCs relied on enhanced mitochondrial function maintain stemness properties, which different from aerobic glycolysis playing main roles in differentiated non‐CSCs. We found exhibit increased respiratory...
The transplantation of bone marrow mesenchymal stem cells (BMSCs) is a promising therapeutic strategy for wound healing. However, the poor migration capacity and low survival rate transplanted BMSCs in wounds weaken their potential application.To identify optimal protocol preconditioned with H2O2 improve efficacy using H2O2-preconditioned healing.Mouse were exposed to various concentrations H2O2, key cellular functional properties assessed determine precondition H2O2. into mice...
Curcumin has exhibited a protective effect against development of renal fibrosis in animal models, however, its underlying molecular mechanisms are largely unclear. Therefore, we investigated the anti-fibrosis effects curcumin transforming growth factor-β1 (TGF-β1)-induced epithelial-to-mesenchymal transition (EMT), and mechanism by which it mediates phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Human kidney tubular epithelial cells (HKCs) were treated with TGF-β1 or alone, combination...
Acupuncture, a traditional Chinese therapeutic technique, has been put into practice for more than 4000 years and widely used pain management since 1958. However, what is the mechanism underlying acupuncture analgesia effects by stimulation of acupoints, substances receive original mechanical signals from or transforms these effective biological are not well understood. In this work, role collagen fibers at acupoints during on rats was investigated. When structure Zusanli (ST36) destroyed...
Abstract Background The circadian rhythm is an endogenous clock that governs a wide range of physiological functions. In the skin, rhythmic changes in skin barrier function have been investigated at level; however, few studies molecular level reported. Additionally, there no study on lipidomic profile variations surface lipid (SSL), which could potentially explain status. Objectives SSL healthy young women was analysed to assess and status during cycle. Methods Ultra performance liquid...
Self-reported skin discomfort is a common problem during pregnancy, but it not clear whether barrier function altered in the process. Few studies have described pregnancy. In this work, we used highly sensitive and high-resolution ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) to distinguish surface lipid (SSL) combined with multivariate analysis of lipids metabolic changes determine relationship between SSL physiology pregnancy order...
Background/Objective: Sinomenine hydrochloride (SH), a natural anti–rheumatic drug derived from the Chinese medicinal plant Sinomenium acutum, demonstrates disease–modifying properties but lacks comprehensive safety and toxicokinetic (TK) comparisons between physiological pathological states. This study evaluated SH’s profile, TK parameters, intestinal absorption differences in adjuvant–induced arthritis (AIA) normal rats. Methods: Safety assessments determined median lethal doses (LD50)...
Osteosarcoma is a common malignant bone tumour in adolescents and old people, with highly invasive metastatic features poor prognosis. This study aimed to explore the role of miR-384 osteosarcoma MG63 cells by targeting SLBP. Cell viability, migration invasion, apoptosis, as well apoptosis-related factors were evaluated CCK-8 assay, Transwell flow cytometer Western blotting, respectively. Dual-luciferase reporter assay was used determine target miR-384. SLBP level analyzed using qRT-PCR...
Multipotent mesenchymal stem cells (MSCs) have high self-renewal and multi-lineage differentiation potentials low immunogenicity, so they attracted much attention in the field of regenerative medicine a promising clinical application. MSCs originate from mesoderm can differentiate not only into osteoblasts, cartilage, adipocytes, muscle but also ectodermal endodermal cell lineages across embryonic layers. To design therapy for replacement damaged tissues, it is essential to understand...
Paclitaxel resistance is a major obstacle for the treatment of ovarian cancer. The chemoresistance mechanisms are partly related to mitochondria. Identification relevant proteins in mitochondria will help clarifying possible and selecting effective chemotherapy patients with paclitaxel resistance. In present study, from two paclitaxel-sensitive human cancer cell lines (SKOV3 A2780) their corresponding resistant (SKOV3-TR A2780-TR) were isolated. Guanidine-modified acetyl-stable isotope...
Procaine (PCA) is a conventional chemotherapeutic agent for osteosarcoma. Recent studies have proposed that the growth-inhibitory effect of PCA through regulation microRNAs (miRNAs). miR-133b has been proven to be tumor suppressor in osteosarcoma, but whether it involved antitumor effects on osteosarcoma not investigated. In this study, we aimed explore MG63 cells by miR-133b, as well its underlying mechanisms. were treated with different concentrations PCA, and cell viability, apoptosis,...
Ligustrazine (TMP) has recently been used for the treatment of various cancers. However, its exact mechanisms action, particularly functions and in human hormone-refractory prostate cancer (HRPC), have not yet extensively studied. Recently, our findings suggest that dose- time-dependently inhibits growth HRPC cells by reducing their proliferation promoting apoptosis. Interestingly, (PC-3) with results a significant inhibition activation mTOR related downstream targets, which are critical...
The transcription factor SOX9 is frequently amplified in diverse advanced-stage human tumors. Its stability has been shown to be tightly controlled by ubiquitination-dependent proteasome degradation. However, the exact underlying molecular mechanisms remain unclear. This work reports that protein abundance regulated Cullin 3-based ubiquitin ligase KEAP1 via proteasome-mediated Loss-of-function mutations compromise polyubiquitination-mediated degradation, leading increased levels, which...
Abstract Aims Coagulation abnormality is one of the primary concerns for patients with spontaneous intracerebral hemorrhage admitted to ER. Conventional laboratory indicators require hours coagulopathy diagnosis, which brings difficulties appropriate intervention within optimal window. This study evaluates possibility building efficient prediction models using data mining and machine learning algorithms. Methods A retrospective cohort enrolled 1668 cases acute from three medical centers,...
Abstract Aims Hypokalemia is a common complication following traumatic brain injury, which may complicate treatment and lead to unfavorable outcomes. Identifying patients at risk of hypokalemia on the first day admission helps implement prophylactic treatment, reduce complications, improve prognosis. Methods This multicenter retrospective study was performed between January 2017 December 2020 using electronic medical records admitted due injury. A propensity score matching approach adopted...
Hemostasis in vivo is a key to success minimally invasive surgery (MIS). However, solid hemostatic materials cannot pass through the sheath tube of MIS apparatus, while liquid ones are restricted by their low adhesion, which leads them peeling off tissue. To tackle dilemma fluidity and formulation containing multifunctional sucrose allyl ether (SAE) monomer an alpha-hydroxyketone photoinitiator (HMPP) was applied as lead material for MIS. Real-time infrared results showed that SAE initiated...