A5100427296- Research in Cotton Cultivation
- Plant Virus Research Studies
- Plant Gene Expression Analysis
- Plant pathogens and resistance mechanisms
- Plant and Fungal Interactions Research
- Angiogenesis and VEGF in Cancer
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Insect-Plant Interactions and Control
- Plant Disease Resistance and Genetics
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Plant-Microbe Interactions and Immunity
- Plant biochemistry and biosynthesis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Peptidase Inhibition and Analysis
- Lipid metabolism and disorders
- Ginseng Biological Effects and Applications
- Liver Disease Diagnosis and Treatment
- Fungal Plant Pathogen Control
- Autophagy in Disease and Therapy
- Seed Germination and Physiology
- Sunflower and Safflower Cultivation
- Plant Pathogens and Fungal Diseases
- Cancer, Lipids, and Metabolism
Hebei Agricultural University
2018-2024
Ministry of Agriculture and Rural Affairs
2024
State Key Laboratory of Luminescent Materials and Devices
2021
South China University of Technology
2021
Jiangsu University
2021
University of California, Santa Cruz
2014-2020
Chizhou University
2020
First Hospital of Jilin University
2019
Jilin University
2019
Children's Hospital of Chongqing Medical University
2019
Abstract Cotton produces natural fiber for the textile industry. The genetic effects of genomic structural variations underlying agronomic traits remain unclear. Here, we generate two high-quality genomes Gossypium hirsutum cv. NDM8 and barbadense acc. Pima90, identify large-scale in species 1,081 G . accessions. density is higher D-subgenome than A-subgenome, indicating that undergoes stronger selection during formation variety development. Many genes and/or regulatory regions potentially...
Due to overcoming the limitation of aggregation caused quenching (ACQ) solid-state emitters, aggregation-induced emission (AIE) organic luminogens have become a promising candidate in aqueous electrochemiluminescence (ECL). However, restricted by physical nature fluorescence, current AIE luminogen-based ECL (AIECL) faces bottleneck low efficiency. Here, we propose construct de novo based on delayed fluorescence (AIDF) luminogens, called AIDF-ECL. Compared with previous purely AIDF integrate...
Strains of the chestnut blight fungus Cryphonectria parasitica harboring RNA viruses genus Hypovirus exhibit significantly reduced levels virulence (called hypovirulence). The accumulation a heterotrimeric GTP-binding protein (G protein) alpha subunit Gi class was found to be in hypovirus-containing C. strains. Transgenic cosuppression, phenomenon frequently observed transgenic plants, this virus-free fungal Significantly, resulting strains were also hypovirulent. These results indicate...
Oncogenic mutations drive anabolic metabolism, creating a dependency on nutrient influx through transporters, receptors, and macropinocytosis. While sphingolipids suppress tumor growth by downregulating macropinocytosis autophagy still provide cancer cells with fuel. Therapeutics that simultaneously disrupt these parallel access pathways have potential as powerful starvation agents. Here, we describe water-soluble, orally bioavailable synthetic sphingolipid, SH-BC-893, triggers transporter...
As the largest cultivated fiber crop in world, cotton (Gossypium hirsutum) is often exposed to various biotic stresses during its growth periods. Verticillium wilt caused by dahliae a severe disease cotton, and molecular mechanism of resistance for needs be further investigated. Here, we revealed that genome contains nine types GST genes. An evolutionary analysis showed newly identified cluster (including Gh_A09G1508, Gh_A09G1509 Gh_A09G1510) located on chromosome 09 A-subgenome was under...
Cotton (Gossypium hirsutum) is constantly attacked by pathogens and insects. The most efficient control strategy to develop resistant varieties using broad-spectrum gene resources. Several resistance loci harboured superior have been identified through genome-wide association studies. However, the key genes and/or not functionally identified. In this study, we a locus significantly associated with Verticillium wilt (VW) resistance, within 145.5-kb linkage disequilibrium, two non-specific...
Abstract Although recombination does not usually occur in the male Drosophila germline, site-specific can be induced at ends of P elements. This finding suggested that could used to map mutations. In this article, we describe general method and its application mapping two EMS-induced female-sterile mutations, grauzone cortex. Within months, gene was mapped relative seven different P-element insertion sites, cortex 23 P-elements. The results allowed us a region about 50 kb, distal chromosomal...
Abstract Lipids are major and essential constituents of plant cells provide energy for various metabolic processes. However, the function lipid signal in defence against Verticillium dahliae , a hemibiotrophic pathogen, remains unknown. Here, we characterized 19 conserved stearoyl‐ACP desaturase family proteins from upland cotton ( Gossypium hirsutum ). We further confirmed that GhSSI2 isoforms, including GhSSI2‐A GhSSI2‐B GhSSI2‐C located on chromosomes A10, D10, A12, respectively, played...
Liver has numerous critical metabolic functions including lipid metabolism, which is usually dysregulated in obesity, the syndrome, and non-alcoholic fatty liver disease (NAFLD). Increasing evidence indicates bone morphogenetic proteins (BMPs) play an important role adipogenesis thermogenic balance adipogenic progenitors adipose tissue. However, direct impact of BMPs on hepatic steatosis possible association with NAFLD are poorly understood. Here, we found that BMP4 was up-regulated oleic...
Verticillium wilt (VW), a fungal disease caused by dahliae, currently devastates cotton fiber yield and quality seriously, yet few resistance germplasm resources have been discovered in Gossypium hirsutum. The variety Nongda601 with suitable VW high was developed our lab, which supplied elite for discovering resistant genes. Early nodulin-like protein (ENODL) is mainly related to nodule formation, its role regulating defense response has seldom studied. Here, 41 conserved ENODLs G. hirsutum...
Glioma is the most common type of primary intracranial tumor. Dysregulation circular RNAs (circRNAs) plays a critical role in multiple solid tumors. However, expression profiles circRNAs and their functions glioma have been rarely studied. The current work aims to investigate clinical significance novel circRNA, circ-POSTN, explore its biological mechanisms progression glioma. We found that circ-POSTN was highly expressed tissue samples cells. High significantly linked larger tumor size,...
Abstract Background Dirigent (DIR) proteins mediate regioselectivity and stereoselectivity during lignan biosynthesis are also involved in lignin, gossypol pterocarpan biosynthesis. This gene family plays a vital role enhancing stress resistance secondary cell-wall development, but systematical understanding is lacking cotton. Results In this study, 107 GbDIRs GhDIRs were identified Gossypium barbadense hirsutum , respectively. Most of these genes have classical structure without intron...
Fiber quality is a major breeding goal in cotton, but phenotypically direct selection often hindered. In this study, we identified fiber and yield related loci using GWAS based on 2.97 million SNPs obtained from 10.65× resequencing data of 1081 accessions. The results showed that 585 novel loci, including two stable SNP peaks associated with length chromosomes At12 Dt05 one genome regions linked strength chromosome Dt12 were identified. Furthermore, by means gene expression analysis,...
In this study, the inhibitory and apoptosis-inducing effect of ginsenoside F4 (GF4) from steamed notoginseng was investigated by using human lymphocytoma Jurkat (JK) cell. Cell Counting Kit-8 method then used to assess anti-proliferative GF4, Western blotting run detect expression level two apoptosis-related proteins including Bax Bcl-2. The results suggested that GF4 can effectively inhibit proliferation cells, increased gradually, but Bcl-2 reduced with increase concentration. conclusion,...
The most common cancer among humans is lung cancer. Non-small cell (NSCLC) comprises the majority of these cases. In development and progression cancers across spectrum, tumor abnormal protein (TAP) plays crucial roles. Additionally, in advancement bladder colorectal cancers, involvement glycoproteins like TAP present. However, it worth noting that current literature has yet to clarify clinical significance NSCLC.In present study, evaluate relative level TAP, we utilized a detection agent...
Employing salicylic acids and substituted 3-butyn-2-ones as the substrates, a morpholine catalyzed tandem dual Michael addition afforded benzodioxin skeleton.
12-Lipoxygenase (12-LO) and angiotensin II (Ang II) are involved in the development of diabetic renal hypertrophy, which cyclin-kinase inhibitors, p21 p27 play pivotal roles. Here, we study effects 12-LO its interaction with Ang on glomerular expression conditions.Models used current include mesangial cells (MCs); glomeruli from (1) type 2 db/db mice; (2) rats induced by high-fat diet feeding followed streptozotocin injection; (3) knockout (12-LOKO) (4) normal infused or...