A5033559773- Epigenetics and DNA Methylation
- Fibroblast Growth Factor Research
- Neurogenesis and neuroplasticity mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Developmental Biology and Gene Regulation
- Metastasis and carcinoma case studies
- Wnt/β-catenin signaling in development and cancer
- Pancreatic function and diabetes
- RNA modifications and cancer
- Congenital heart defects research
- dental development and anomalies
- Advanced MRI Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Cytomegalovirus and herpesvirus research
- Genital Health and Disease
- AI in cancer detection
- Sexual function and dysfunction studies
- T-cell and Retrovirus Studies
- Oral and Maxillofacial Pathology
- Cancer-related gene regulation
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Pluripotent Stem Cells Research
- Mechanisms of cancer metastasis
- Neonatal Respiratory Health Research
University of California, San Francisco
2008-2016
Public Library of Science
2015-2016
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2002-2015
Appalachian State University
2008
Fred Hutch Cancer Center
2006
North Seattle College
2006
National Cancer Institute
1999
Stanford University
1999
Frederick National Laboratory for Cancer Research
1999
Georgetown University
1997
To better understand the molecular basis for hormone-responsive phenotype in breast cancer, we have used a human cDNA array to compare patterns of gene expression between carcinoma cell lines discordant estrogen receptor (ER) expression. These experiments indicated abundant transcription factor GATA-3 ER-positive MCF7 and T-47D, with minimal or no ER-negative cells MDA-MB-231 HBL-100. Northern blot analysis panel demonstrated correlation ER Studies grown absence presence β-estradiol that was...
Fibroblast growth factor receptor 1 (Fgfr1) plays pleiotropic roles during embryonic development, but the mechanisms by which this signals in vivo have not previously been elucidated. Biochemical studies implicated Fgf receptor-specific substrates (Frs2, Frs3) as principal mediators of Fgfr1 signal transduction to MAPK and PI3K pathways. To determine developmental requirements for Fgfr1-Frs signaling, we generated mice (Fgfr1(Delta)Frs/DeltaFrs) Frs2/3-binding site on is deleted....
Fibroblast growth factor (Fgf) signaling governs multiple processes important in development and disease. Many lines of evidence have implicated Erk1/2 induced through Frs2 as the predominant effector pathway downstream from Fgf receptors (Fgfrs), but these can also signal other mechanisms. To explore functional significance full range Fgfrs mice, we engineered an allelic series knock-in point mutations designed to disrupt Fgfr1 functions individually combination. Analysis each mutant...
The Otx2 homeodomain transcription factor is essential for gastrulation and early neural development. We generated conditional knockout (cKO) mice to investigate its roles in telencephalon development after neurulation (approximately embryonic day 9.0). conducted transcriptional profiling situ hybridization identify genes de-regulated cKO ventral forebrain. In parallel, we used chromatin immunoprecipitation sequencing enhancer elements, the OTX2 binding motif, that are likely direct targets...
The rostral patterning center (RPC) secretes multiple fibroblast growth factors (Fgfs) essential for telencephalon and patterning. Fgf expression patterns suggest that they mark functionally distinct RPC subdomains. We generated Fgf8(CreER) Fgf17(CreER) mice used them to analyze the lineages of Fgf8- versus Fgf17-expressing cells.Both contributed medial structures rostroventral including septum prefrontral cortex. In addition, RPC-derived progenitors were observed in other regions early...
Estrogen receptor (ER) α and β aromatase are expressed in various cell-types compartments of the penis, including epidermis glans penis. Here, we hypothesize that estrogen helps maintain viability integrity penis test hypothesis by treating lesioned with either 17β-estradiol or vehicle only. was found to facilitate wound healing increase vascular endothelial growth factor (VEGF) immunoreactivity compared control, as revealed scanning electron microscopy, histology, immunohistochemistry. We...
To better understand the molecular basis for hormone-responsive phenotype in breast cancer, we have used a human cDNA array to compare patterns of gene expression between carcinoma cell lines discordant estrogen receptor (ER) expression. These experiments indicated abundant transcription factor GATA-3 ER-positive MCF7 and T-47D, with minimal or no ER-negative cells MDA-MB-231 HBL-100. Northern blot analysis panel demonstrated correlation ER Studies grown absence presence β-estradiol that was...