Sumitra Muralidhar
A5044845889- Genetic Associations and Epidemiology
- Cytomegalovirus and herpesvirus research
- Bipolar Disorder and Treatment
- Viral-associated cancers and disorders
- COVID-19 Clinical Research Studies
- Ethics in Clinical Research
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- Liver Disease Diagnosis and Treatment
- Schizophrenia research and treatment
- Health, Environment, Cognitive Aging
- BRCA gene mutations in cancer
- Primary Care and Health Outcomes
- Alcohol Consumption and Health Effects
- RNA modifications and cancer
- Gene expression and cancer classification
- Suicide and Self-Harm Studies
- Biomedical Text Mining and Ontologies
- Parvovirus B19 Infection Studies
- Health Systems, Economic Evaluations, Quality of Life
- Health disparities and outcomes
- Intensive Care Unit Cognitive Disorders
- Herpesvirus Infections and Treatments
- Lipoproteins and Cardiovascular Health
- Health Policy Implementation Science
VA Office of Research and Development
2012-2025
United States Department of Veterans Affairs
2019-2024
Veterans Health Administration
2015-2024
Jain University
2024
Yale University
2024
University of Utah
2023
VA Boston Healthcare System
2023
Boston University
2023
Government of the United States of America
2022
Washington DC VA Medical Center
2020-2021
ObjectiveTo describe the design and ongoing conduct of Million Veteran Program (MVP), as an observational cohort study mega-biobank in Department Veterans Affairs (VA) health care system.Study Design SettingData are being collected from participants using questionnaires, VA electronic record, a blood sample for genomic other testing. Several projects linked to MVP, both peer-reviewed research studies activities help develop infrastructure future, broad-based uses.ResultsFormal planning MVP...
The Million Veteran Program (MVP), initiated by the Department of Veterans Affairs (VA), aims to collect biosamples with consent from at least one million veterans. Presently, blood samples have been collected over 800,000 enrolled participants. size and diversity MVP cohort, as well availability extensive VA electronic health records, make it a promising resource for precision medicine. is conducting array-based genotyping provide genome-wide scan entire in parallel whole-genome sequencing,...
<h3>Importance</h3> Selecting effective antidepressants for the treatment of major depressive disorder (MDD) is an imprecise practice, with remission rates about 30% at initial treatment. <h3>Objective</h3> To determine whether pharmacogenomic testing affects antidepressant medication selection and such leads to better clinical outcomes. <h3>Design, Setting, Participants</h3> A pragmatic, randomized trial that compared guided by vs usual care. Participants included 676 clinicians 1944...
One of the justifiable criticisms human genetic studies is underrepresentation participants from diverse populations. Lack inclusion must be addressed at-scale to identify causal disease factors and understand causes health disparities. We present genome-wide associations for 2068 traits 635,969 in Department Veterans Affairs Million Veteran Program, a longitudinal study United States Veterans. Systematic analysis revealed 13,672 genomic risk loci; 1608 were only significant after including...
The recently identified human herpesvirus 8 (HHV-8, or Kaposi's sarcoma-associated herpesvirus) has been implicated in the etiology of both sarcoma (KS) and primary effusion (body cavity-based) lymphoma (PEL) (Y. Chang et al., Science 266:1865-1869, 1994; P. S. Moore J. Virol. 70:549-558, 1996). An important feature association HHV-8 with these malignancies is expression an abundant, latency-associated 0.7-kb transcript, T0. 7 (W. Zhong Proc. Natl. Acad. Sci. USA 93:6641-6646, T0.7 found all...
Abdominal aortic aneurysm (AAA) is an important cause of cardiovascular mortality; however, its genetic determinants remain incompletely defined. In total, 10 previously identified risk loci explain a small fraction AAA heritability.We performed genome-wide association study in the Million Veteran Program testing ≈18 million DNA sequence variants with (7642 cases and 172 controls) veterans European ancestry independent replication up to 4972 99 858 controls. We then used mendelian...
Abstract Serum concentration of hepatic enzymes are linked to liver dysfunction, metabolic and cardiovascular diseases. We perform genetic analysis on serum levels alanine transaminase (ALT), alkaline phosphatase (ALP) gamma-glutamyl transferase (GGT) using data 437,438 UK Biobank participants. Replication in 315,572 individuals from European descent the Million Veteran Program, Rotterdam Study Lifeline study confirms 517 enzyme SNPs. Genetic risk score identified SNPs is strongly associated...
Abstract Background Schizophrenia (SCZ) and bipolar disorder (BIP) are debilitating neuropsychiatric disorders, collectively affecting 2% of the world’s population. Recognizing major impact these psychiatric disorders on psychosocial function more than 200 000 US Veterans, Department Veterans Affairs (VA) recently completed genotyping 8000 veterans with SCZ BIP in Cooperative Studies Program (CSP) #572. Methods We performed genome-wide association studies (GWAS) CSP #572 benchmarked...
End-stage renal disease is associated with a high risk of cardiovascular events. It unknown, however, whether mild-to-moderate kidney dysfunction causally related to coronary heart (CHD) and stroke. Observational analyses were conducted using individual-level data from 4 population sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer Nutrition-Cardiovascular Disease Study], Million Veteran Program, UK Biobank), comprising 648 135 participants...
Serious mental illnesses, including schizophrenia, bipolar disorder, and depression, are heritable, highly multifactorial disorders major causes of disability worldwide.
Abstract Genome-wide association studies (GWAS) have underrepresented individuals from non-European populations, impeding progress in characterizing the genetic architecture and consequences of health disease traits. To address this, we present a population-stratified phenome-wide GWAS followed by multi-population meta-analysis for 2,068 traits derived electronic records 635,969 participants Million Veteran Program (MVP), longitudinal cohort study diverse U.S. Veterans genetically similar to...
Human herpesvirus 8 is the etiologic agent associated with Kaposi's sarcoma and primary effusion lymphoma (PEL). The K12 RNA, which produces as many three variants of kaposin protein, well a microRNA, most abundant transcript expressed in latent sarcoma-associated infection, yet it also induced during lytic replication. portion that includes microRNA A sequence has been shown to have tumorigenic potential. Genome coordinate 117990, within this transcript, found be heterogeneous, primarily...
Following reports of an increased incidence amyotrophic lateral sclerosis (ALS) in U.S. veterans, we have conducted a high-density genome-wide association study (GWAS) ALS outcome and survival time sample veterans. We tested ∼1.3 million single nucleotide polymorphisms (SNPs) for with 442 incident Caucasian veteran cases diagnosed definite or probable 348 controls. To increase power, also included genotypes from 5909 publicly-available non-veteran controls the analysis. In analysis, between...
Importance Alcohol genome-wide association studies (GWASs) have generally focused on alcohol consumption and use disorder (AUD); few examined habitual drinking behaviors like maximum intake (MaxAlc). Objectives To identify genetic loci associated with MaxAlc to elucidate the architecture across traits. Design, Setting, Participants This study was performed among Million Veteran Program participants enrolled from January 10, 2011, September 30, 2020. Ancestry-specific GWASs were conducted in...
Given the prominence of cognitive impairments and disability associated with schizophrenia bipolar disorder, substantial interest has arisen in identifying determinants diseases their features. Genetic variation been linked to skills that underlie (“functional capacity” or FC), highlighting need for understanding these relationships. We describe design methods a large, multisite, observational study focusing on genetics functional presenting initial data recruitment, characterization sample....
<h3>Importance</h3> Sickle cell trait (SCT), defined as the presence of 1 hemoglobin beta sickle allele (rs334-T) and normal allele, is prevalent in millions people US, particularly individuals African Hispanic ancestry. However, association SCT with COVID-19 unclear. <h3>Objective</h3> To assess prepandemic health conditions participants Million Veteran Program (MVP) to severity sequelae COVID-19. <h3>Design, Setting, Participants</h3> clinical data include 2729 persons SCT, whom 353 had...