Nicole Kosik
A5021345004- Heart Failure Treatment and Management
- COVID-19 Clinical Research Studies
- Ethics in Clinical Research
- Genetic Associations and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- interferon and immune responses
- Bioinformatics and Genomic Networks
- Cardiovascular Function and Risk Factors
- Dementia and Cognitive Impairment Research
- Chronic Kidney Disease and Diabetes
- Pancreatitis Pathology and Treatment
- Gene expression and cancer classification
- Heavy Metal Exposure and Toxicity
- RNA modifications and cancer
- Renal Diseases and Glomerulopathies
- Diabetes Treatment and Management
- Air Quality and Health Impacts
- Chronic Disease Management Strategies
- Health, Environment, Cognitive Aging
- Peptidase Inhibition and Analysis
- Advanced Causal Inference Techniques
- Cardiac and Coronary Surgery Techniques
- Cardiac Fibrosis and Remodeling
- Selenium in Biological Systems
- Trace Elements in Health
VA Boston Healthcare System
2012-2023
Coronavirus disease 2019 (COVID-19) confers significant risk of acute kidney injury (AKI). Patients with COVID-19 AKI have high mortality rates.Individuals African ancestry 2 copies apolipoprotein L1 (APOL1) variants G1 or G2 (high-risk group) significantly increased rates disease. We tested the hypothesis that APOL1 high-risk group is associated a higher-risk COVID-19-associated and death.This retrospective cohort study included 990 participants enrolled in Million Veteran Program who were...
Scope Selenium has complex effects in vivo on multiple homeostatic mechanisms such as redox balance, methylation and epigenesis, via its interaction with the methionine‐homocysteine cycle. In this study, we examined hypothesis that selenium status would modulate both balance thereby myocardial structure function. Methods results We of selenium‐deficient (<0.025 mg/kg), control (0.15 selenium‐supplemented (0.5 mg/kg) diets histology, biochemistry function adult C 57/ BL 6 mice. deficiency...
Large biobanks, including the Million Veteran Program (MVP), UK Biobank, and FinnGen, provide genetic association results for more than 1,000,000 individuals hundreds of phenotypes. To select targets pharmaceutical development, as well to improve understanding existing targets, we harmonized these studies, performed two-sample Mendelian Randomization (MR) on 2,003 phenotypes using variants associated with gene expression (derived from GTEx eQTLGen) plasma protein levels ARIC, Fenland,...
<h3>Importance</h3> Sickle cell trait (SCT), defined as the presence of 1 hemoglobin beta sickle allele (rs334-T) and normal allele, is prevalent in millions people US, particularly individuals African Hispanic ancestry. However, association SCT with COVID-19 unclear. <h3>Objective</h3> To assess prepandemic health conditions participants Million Veteran Program (MVP) to severity sequelae COVID-19. <h3>Design, Setting, Participants</h3> clinical data include 2729 persons SCT, whom 353 had...
Myocardial fibrosis, a major pathophysiologic substrate of heart failure with preserved ejection fraction (HFPEF), is modulated by multiple pathways including the renin-angiotensin system. Direct renin inhibition promising anti-fibrotic therapy since it attenuates pro-fibrotic effects in addition to that other effectors cascade. Here we show oral inhibitor aliskiren has direct on collagen metabolism cardiac fibroblasts and prevented myocardial deposition non-hypertrophic mouse model...
Background: Saphenous vein grafts (SVGs) remain the most often used conduits for coronary bypass grafting (CABG). Progressive intimal hyperplasia contributes to vein-graft disease and failure (VGF). We compared impact of intraoperative preservation SVGs in a storage solution (DuraGraft®) versus heparinized saline on VGF-related outcomes after CABG.Methods: From 1996 2004, 2436 patients underwent isolated CABG with ≥ 1 SVG. were consecutively treated DuraGraft 1036 (2001−2004) 1400...
Growing evidence suggests that Alzheimer’s disease and other types of dementia are underdiagnosed poorly documented. In our study, we describe patterns coding treatment in the Veteran’s Administration New England Healthcare System. We conducted a retrospective cohort study with new outpatient ICD-9 codes for several between 2002 2009. examined healthcare utilization, medication use, initial diagnoses, changes diagnoses over time by provider type. 8,999 veterans received during period. Only...
Objective We aimed to characterise self-reported military and occupational exposures including Agent Orange, chemical/biological warfare agents, solvents, fuels, pesticides, metals burn pits among Veterans in the Department of Affairs Million Veteran Program (MVP). Methods MVP is an ongoing longitudinal cohort mega-biobank over one million US Veterans. Over 500 000 participants reported on baseline survey, 300 lifestyle survey. determined frequencies selected by service era, specific...
Abstract We conduct a large-scale meta-analysis of heart failure genome-wide association studies (GWAS) consisting over 90,000 cases and more than 1 million control individuals European ancestry to uncover novel genetic determinants for failure. Using the GWAS results blood protein quantitative loci, we perform Mendelian randomization colocalization analyses on human proteins provide putative causal evidence role druggable in genesis identify 39 significant risk variants, which 18 are...
ABSTRACT We used expression quantitative trait loci (eQTLs) and protein (pQTLs) to conduct genome-wide Mendelian randomization (MR) using 27,799 cases of heart failure (HF) with reduced ejection fraction (HFrEF), 27,579 HF preserved (HFpEF), 367,267 control individuals from the Million Veteran Program (MVP). identified 70 HFrEF 10 HFpEF gene-hits, which 58 are novel. In 14 known for unclassified HF, we as subtype responsible signal. hits ZBTB17 , MTSS1 PDLIM5 MLIP novel NFATC2IP, PABPC4...
Abstract Drug repurposing provides a rapid approach to meet the urgent need for therapeutics address COVID-19. To identify therapeutic targets relevant COVID-19, we conducted Mendelian randomization (MR) analyses, deriving genetic instruments based on transcriptomic and proteomic data 1,263 actionable proteins that are targeted by approved drugs or in clinical phase of drug development. Using summary statistics from Host Genetics Initiative Million Veteran Program, studied 7,554 patients...