A5047156445- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Pharmacogenetics and Drug Metabolism
- Liver Disease and Transplantation
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Drug Transport and Resistance Mechanisms
- COVID-19 Clinical Research Studies
- Poisoning and overdose treatments
- Carcinogens and Genotoxicity Assessment
- Pharmacological Effects and Toxicity Studies
- Gastrointestinal motility and disorders
- Counseling, Therapy, and Family Dynamics
- Long-Term Effects of COVID-19
- Psychotherapy Techniques and Applications
- COVID-19 and healthcare impacts
- Pain Management and Treatment
- Pharmacovigilance and Adverse Drug Reactions
- Attachment and Relationship Dynamics
- SARS-CoV-2 and COVID-19 Research
- Liver Diseases and Immunity
- Geriatric Care and Nursing Homes
- Chronic Kidney Disease and Diabetes
- Counseling Practices and Supervision
- Computational Drug Discovery Methods
Duke Medical Center
1997-2023
Durham VA Health Care System
2018-2023
Duke University Hospital
1991-2023
Mayo Clinic in Florida
2022
Duke University
1997-2022
Durham VA Medical Center
2014-2022
Jacksonville College
2022
University of Michigan
1992-2019
VA Ann Arbor Healthcare System
2019
Virginia Commonwealth University
2019
YMDD variants of hepatitis B virus (HBV) emerge in some patients with chronic who receive lamivudine. were examined 794 4 controlled studies 1 year's duration. The long-term effects a subset treated up to years. detected by polymerase chain reaction (PCR) and restriction fragment-length polymorphism assays. After year, 81 (24%) 335 patients. In these patients, the median serum HBV DNA concentration at year was <20% baseline level, alanine transaminase (ALT) levels liver histologic findings...
Coronavirus disease 2019 (COVID-19) confers significant risk of acute kidney injury (AKI). Patients with COVID-19 AKI have high mortality rates.Individuals African ancestry 2 copies apolipoprotein L1 (APOL1) variants G1 or G2 (high-risk group) significantly increased rates disease. We tested the hypothesis that APOL1 high-risk group is associated a higher-risk COVID-19-associated and death.This retrospective cohort study included 990 participants enrolled in Million Veteran Program who were...
Hepatic iron concentration has consistently been observed as being directly correlated with the response to interferon therapy in chronic hepatitis C virus (HCV). We therefore conducted a randomized, controlled trial comparing reduction by phlebotomy followed retreatment 96 patients who had previously not responded course of interferon. During initial phase when all were undergoing phlebotomy, we found that serum alanine transaminase (ALT) activities decreased but less than 50% from baseline...
Theophylline is metabolized in the liver by one or more cytochrome P-450 enzymes. To assess amounts and types of these human cytochromes P-450, we incubated theophylline with microsomes prepared from 22 different livers presence NADPH, measured simultaneous rates 1- 3-N-demethylations to 3-methylxanthine (3-MX) 1-methylxanthine (1-MX), respectively; 8-hydroxylation 1,3-dimethyluric acid (1,3-DMU). Under optimal conditions, 3-MX, 1-MX, 1,3-DMU formation proceeded mean Km values 2.05, 1.93,...
The N-demethylation of erythromycin and 6β-hydroxylation Cortisol are both functions the glucocorticoid-inducible CYP3A in human liver microsomes. To determine whether catalyzed by similar or distinct isoforms, N-demethylase activity, as reflected recently described 14[C]-erythromycin breath test, was compared with urinary 6β-hydroxycortisol/cortisol ratios, a measure 6β-hydroxylase nine patients. Erythromycin varied fourfold ratios sevenfold among subjects; no correlation found between...
Irritable bowel syndrome (IBS) is diagnosed by the presence of a constellation symptoms fulfilling Manning or Rome Criteria, after exclusion organic disease. To exclude other diagnoses that might contribute to abdominal pain experienced subjects with IBS, numerous screening algorithms have been advocated, incorporating lactose hydrogen breath tests, thyroid function fecal ova and parasite determination, colonic endoscopy/radiography. The utility these tests in uncovering alternative...
Lapatinib is a clinically important component of the treatment for HER2-positive metastatic breast cancer and has an acceptable safety profile. Lapatinib-associated Hy's Law cases have been characterized using human leukocyte antigen (HLA) DQA1*02:01/DRB1*07:01 Gilbert's syndrome UGT1A1*28/*28 genotypes. The HLA-positive had higher alanine aminotransferase (ALT) elevation, whereas HLA-negative incidence syndrome. findings our study, which extend this HLA association to lapatinib-associated...
Tolvaptan is associated with risk of drug-induced liver injury when used to treat autosomal dominant polycystic kidney disease (ADPKD). After this was described based on the clinical trials TEMPO 3:4 and 4:4, additional data from REPRISE trial a long-term extension REPRISE, other tolvaptan in ADPKD have become available. To further characterize hepatic safety profile tolvaptan, an analysis expanded dataset conducted.Analysis prospective tolvaptan.Multicenter including more than 2,900...
Employment, functional status, health and prevalence of anxiety depression were assessed in patients who had undergone orthotopic liver transplantation at Duke University from 1984 to 1993 identify social economic factors that might influence return work after transplantation. Patients asked complete mailed questionnaires. A transplant nurse coordinator assigned a Karnofsky score, unaware the questionnaire responses. The response rate was 71% (52 72 patients). median age post-liver 49 years....
Summary Background With its increasing incidence, nonalcoholic fatty liver disease ( NAFLD ) is of particular concern in the Veterans Health Administration VHA ). Aims To evaluate risk factors for advanced fibrosis biopsy‐proven VHA, to identify patients at adverse outcomes. Methods In randomly selected cases from databases (2005‐2015), we performed a retrospective case‐control study adults with biopsy‐defined or normal liver. Results Of 2091 reviewed, 399 met inclusion criteria. Normal...