A5070467866- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Organ Transplantation Techniques and Outcomes
- Poisoning and overdose treatments
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Hepatitis Viruses Studies and Epidemiology
- Liver Diseases and Immunity
- Pancreatitis Pathology and Treatment
- Pharmacological Effects and Toxicity Studies
- Systemic Lupus Erythematosus Research
- HIV/AIDS drug development and treatment
- Metabolism and Genetic Disorders
- Liver physiology and pathology
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hepatocellular Carcinoma Treatment and Prognosis
- Electrolyte and hormonal disorders
- Sepsis Diagnosis and Treatment
- Livestock and Poultry Management
- Genetic and phenotypic traits in livestock
- Immune Cell Function and Interaction
- Blood donation and transfusion practices
The University of Texas Southwestern Medical Center
2016-2025
Southwestern Medical Center
2016-2025
University of California, San Francisco
2000-2024
Hepatitis B Foundation
2021-2023
Research Network (United States)
2021-2023
Christiana Care Health System
2020-2022
University of North Carolina at Chapel Hill
2021
Parkland Health & Hospital System
2012-2020
University of Michigan
2003-2020
University of Southern California
2011-2020
Only 15 to 20 percent of patients with chronic hepatitis C have a sustained virologic response interferon therapy. We compared the efficacy and safety recombinant alfa-2b alone those combination ribavirin for initial treatment C.
Background: Because acute liver failure is rare, related data have been sparse. Studies suggested that viral hepatitis the most common underlying cause of this condition. Objective: To describe clinical features, presumed causes, and short-term outcomes failure. Design: Prospective cohort study. Setting: 17 tertiary care centers participating in U.S. Acute Liver Failure Study Group. Patients: 308 consecutive patients with failure, admitted over a 41-month period. Measurements: Detailed...
Severe acetaminophen hepatotoxicity frequently leads to acute liver failure (ALF). We determined the incidence, risk factors, and outcomes of acetaminophen-induced ALF at 22 tertiary care centers in United States. Detailed prospective data were gathered on 662 consecutive patients over a 6-year period fulfilling standard criteria for (coagulopathy encephalopathy), from which 275 (42%) result injury. The annual percentage acetaminophen-related rose during study 28% 1998 51% 2003. Median dose...
Treatment guidelines recommend the use of peginterferon alfa-2b or alfa-2a in combination with ribavirin for chronic hepatitis C virus (HCV) infection. However, these regimens have not been adequately compared.At 118 sites, patients who had HCV genotype 1 infection and previously treated were randomly assigned to undergo 48 weeks treatment one three regimens: at a standard dose 1.5 microg per kilogram body weight week low 1.0 week, plus 800 1400 mg day, 180 1000 1200 day. We compared rate...
These recommendations provide a data-supported approach. They are based on the following: (1) formal review and analysis of recently-published world literature topic [Medline search], (2) American College Physicians Manual for Assessing Health Practices Designing Practice Guidelines,1 (3) guideline policies, including AASLD Policy Development Use Guidelines AGA Statement Guidelines,2 (4) experience authors in specified topic. ALF, acute liver failure; NAC, N-acetylcysteine; HELLP, Hemolysis,...
Idiosyncratic drug-induced liver injury (DILI) is a rare adverse drug reaction and it can lead to jaundice, failure, or even death. Antimicrobials herbal dietary supplements are among the most common therapeutic classes cause DILI in Western world. diagnosis of exclusion thus careful history taking thorough work-up for competing etiologies essential its timely diagnosis. In this ACG Clinical Guideline, authors present an evidence-based approach management with special emphasis on due...
Acute liver failure (ALF) is a rare but challenging clinical syndrome with multiple causes; specific etiology cannot be identified in 15% of adult and 50% pediatric cases. The course ALF variable the mortality rate high. Liver transplantation only therapy proven benefit, rapidity progression limit its use. Currently United States, spontaneous survival occurs approximately 45%, 25%, death without 30% adults ALF. Higher rates recovery (56%) (31%) lower (13%) occur children. outcome varies by...
Acute liver failure (ALF) due to drug-induced injury (DILI), though uncommon, is a concern for both clinicians and patients. The Liver Failure Study Group has prospectively collected cases of all forms acute since 1998. We describe here idiosyncratic DILI ALF enrolled during 10.5-year period. Data were prospectively, using detailed case report forms, from 1198 subjects at 23 sites in the United States, which had transplant services. A total 133 (11.1%) deemed by expert opinion have DILI;...
Abstract Retrospective studies suggest that subjects with chronic hepatitis C and advanced fibrosis who achieve a sustained virological response (SVR) have lower risk of hepatic decompensation hepatocellular carcinoma (HCC). In this prospective analysis, we compared the rate death from any cause or liver transplantation, liver-related morbidity mortality, after antiviral therapy among patients achieved SVR, virologic nonresponders (NR), those initial viral clearance but subsequent...
In patients with chronic hepatitis C who do not have a response to antiviral treatment, the disease may progress cirrhosis, liver failure, hepatocellular carcinoma, and death. Whether long-term therapy can prevent progressive in such remains uncertain.We conducted randomized, controlled trial of peginterferon alfa-2a at dosage 90 microg per week for 3.5 years, as compared no 1050 advanced fibrosis had previous ribavirin. The patients, were stratified according stage (622 noncirrhotic 428...
The prevalence and characteristics of acetaminophen-associated liver injury in hospitalized patients are not well defined.