A5084970543- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- HIV/AIDS Research and Interventions
- Birth, Development, and Health
- HIV-related health complications and treatments
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Risk Factors
- RNA modifications and cancer
- Genetic and phenotypic traits in livestock
- Physiological and biochemical adaptations
- Aquaculture Nutrition and Growth
- Genomics and Rare Diseases
- Genetic Mapping and Diversity in Plants and Animals
- Cardiovascular Disease and Adiposity
- Lipoproteins and Cardiovascular Health
- Nutrition, Genetics, and Disease
- Lipid metabolism and disorders
- Aquaculture disease management and microbiota
- Diabetes Treatment and Management
- Health and Medical Research Impacts
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Liver Disease Diagnosis and Treatment
- Intergenerational Family Dynamics and Caregiving
Emory University
2016-2025
Atlanta VA Health Care System
2020-2025
China-Japan Friendship Hospital
2021-2025
Sun Yat-sen University
2019-2024
Vanderbilt University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Atlanta VA Medical Center
2019-2024
Boston University
2024
Case Western Reserve University
2024
VA Tennessee Valley Healthcare System
2024
Elevated body mass index (BMI) is heritable and associated with many health conditions that impact morbidity mortality. The study of the genetic association BMI across a broad range common disease offers opportunity to extend current knowledge regarding breadth depth adiposity-related diseases. We identify 906 (364 novel) 41 (6 genome-wide significant loci for among participants European (N~1.1 million) African (N~100,000) ancestry, respectively. Using risk score including 2446 variants, 316...
Hypertension is a leading cause of global disease, mortality, and disability. While individuals African descent suffer disproportionate burden hypertension its complications, they have been underrepresented in genetic studies. To identify novel susceptibility loci for blood pressure people ancestry, we performed both single multiple-trait genome-wide association analyses. We analyzed 21 studies comprised 31,968 validated our results with additional 54,395 from multi-ethnic These analyses...
Abstract Pharmacologic clinical trials for heart failure with preserved ejection fraction have been largely unsuccessful as compared to those reduced fraction. Whether differences in the genetic underpinnings of these major subtypes may provide insights into disparate outcomes remains unknown. We utilize a large, uniformly phenotyped, single cohort sub-classified and fractions based on current definitions, conduct detailed analyses two sub-types. find different architectures distinct...
Importance Body mass index (BMI; calculated as weight in kilograms divided by height meters squared) is a commonly used estimate of obesity, which complex trait affected genetic and lifestyle factors. Marked gain loss could be associated with adverse biological processes. Objective To evaluate the association between BMI variability incident cardiovascular disease (CVD) events 2 distinct cohorts. Design, Setting, Participants This cohort study data from Million Veteran Program (MVP) 2011...
Severe obesity (SevO) is a primary driver of cardiovascular diseases (CVD), cardiometabolic (CMD) and several cancers, with disproportionate impact on marginalized populations. SevO an understudied global health disease, limiting knowledge about its mechanisms impacts. In genome-wide association study (GWAS) meta-analyses the tail end BMI distribution (≥95th percentile BMI) two phenotypes [Obesity Class III ≥40 kg/m2 Obesity IV ≥50 kg/m2] in 159,359 individuals across eleven ancestrally...
HIV-positive individuals are at higher risk than healthy persons for aging-related diseases, including myocardial infarction and non-AIDS defining cancers. Recent evidence suggests that HIV infection may modulate changes in the host cell epigenome, these represent a potential mechanism through which accelerates aging. We assessed difference DNA methylation (DNAm) age, an aging marker involving multiple age-related cytosine-guanine dinucleotide (CpG) sites, among antiretroviral treatment...
Background: The genomic structure that contributes to the risk of coronary artery disease (CAD) can be evaluated as a score multiple variants. However, sex differences have not been fully examined in applications genetic (GRS) CAD. Methods: Using data from UK Biobank, we constructed CAD-GRS based on all known loci, 3 mediating trait-based (blood pressure, lipids, and body mass index) subscores, genome-wide polygenic 1.1 million associations with prevalent incident CAD between men women were...
Abstract Background Little is known about the role of DNA methylation (DNAm) epigenetic age acceleration in cognitive decline. Using a twin study design, we examined whether DNAm related to decline measured longitudinally persons without clinical diagnosis dementia. Methods We studied 266 paired male twins (133 pairs) with mean 56 years at baseline. Of these, 114 returned for follow-up after an average 11.5 years. obtained 6 indices based on epigenome-wide data from peripheral blood...
The integration of metabolic signals required for the regulation hepatic lipid homeostasis is complex. Previously, we showed that mice lacking expression mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) have increased fatty acid oxidation and are protected from development steatosis. Here, show leptin receptor-deficient (db/db) MKP-1 also resistant to Microarray analyses livers db/db suppression peroxisome proliferator-activated receptor γ (PPARγ) target genes. We identified...
Alternative splicing (AS) is an important post-transcriptional regulatory mechanism for cells to generate transcript variability and proteome diversity. No systematic investigation of AS events among different tissues in response stressors available tilapia currently. In this study, was identified the cold stress-related were explored a Nile (Oreochromis niloticus) line based on 42 RNA-seq datasets using bioinformatics pipeline. 14,796 (82.76%; SD = 2,840) expression genes showed events. The...
The prevalence of childhood overweight and obesity in China has been rapidly increasing recent years. purposes this study were to investigate the infant Beijing explore influencing factors using a generalized estimating equation (GEE) model. This is birth cohort from January 2022 December Beijing, involving 2,008 newborns local residents. Four times follow-up visits conducted at 2, 5, 8, 12 months age for physical measurements health information collection. Multiple exposures considered,...
Tobacco smoking is a major cause of chronic disease worldwide. Smoking may induce cellular and molecular changes including epigenetic modification, with both short-term long-term modification patterns that contribute to phenotypic expression diseases. Recent epigenome-wide association studies (EWAS) have identified dozens smoking-related DNA methylation (DNAm) sites. However, the X chromosomal DNAm sites been largely overlooked due lack an analytical framework for dealing sex-dimorphic...