Albert W. Dreisbach
A5019678995- Genetic Associations and Epidemiology
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects and Toxicity Studies
- Renal Diseases and Glomerulopathies
- Nutrition, Genetics, and Disease
- Eicosanoids and Hypertension Pharmacology
- Birth, Development, and Health
- Drug Transport and Resistance Mechanisms
- Chronic Kidney Disease and Diabetes
- Blood Pressure and Hypertension Studies
- Alcohol Consumption and Health Effects
- Metabolism and Genetic Disorders
- Electrolyte and hormonal disorders
- Dialysis and Renal Disease Management
- Neurological Complications and Syndromes
- Anesthesia and Sedative Agents
- Treatment of Major Depression
- HIV/AIDS drug development and treatment
- Health, Environment, Cognitive Aging
- Renin-Angiotensin System Studies
- Renal and related cancers
- Nutritional Studies and Diet
- Fatty Acid Research and Health
- Muscle and Compartmental Disorders
- Neurological and metabolic disorders
University of Mississippi Medical Center
2008-2021
VA New Jersey Health Care System
2021
University of Mississippi
2008-2016
State Street (United States)
2008-2016
Jackson Memorial Hospital
2008-2015
University of Iceland
2014
University of Virginia Health System
2014
Edward Via College of Osteopathic Medicine
2014
Louisiana State University Health Sciences Center Shreveport
2014
Icelandic Heart Association
2014
The optimal intensity of renal-replacement therapy in critically ill patients with acute kidney injury is controversial.We randomly assigned and failure at least one nonrenal organ or sepsis to receive intensive less therapy. primary end point was death from any cause by day 60. In both study groups, hemodynamically stable underwent intermittent hemodialysis, unstable continuous venovenous hemodiafiltration sustained low-efficiency dialysis. Patients receiving the treatment strategy...
Hypertension is a leading cause of global disease, mortality, and disability. While individuals African descent suffer disproportionate burden hypertension its complications, they have been underrepresented in genetic studies. To identify novel susceptibility loci for blood pressure people ancestry, we performed both single multiple-trait genome-wide association analyses. We analyzed 21 studies comprised 31,968 validated our results with additional 54,395 from multi-ethnic These analyses...
ObjectivesTo determine: (1) the pharmacokinetics and safety of an investigational aminoquinoline active against multidrug–resistant malaria parasites (AQ-13), including its effects on QT interval, (2) whether it has pharmacokinetic profiles similar to chloroquine (CQ) in humans.DesignPhase I double-blind, randomized controlled trials compare AQ-13 CQ healthy volunteers. Randomizations were performed at each step after completion previous dose.SettingTulane–Louisiana State University–Charity...
Background Controversy exists regarding the association of cigarette smoking and renal dysfunction, particularly among African Americans, who are disproportionately affected by chronic kidney disease; therefore, we evaluated relationship between rapid function ( RRF ) decline in Jackson Heart Study. Methods Results Rates were determined 3648 American participants enrolled at baseline was defined as an absolute estimated glomerular filtration rate 30% from visit 1 to 3. There 422 current, 659...
Objective To determine the in-vitro and in-vivo effects of CYP2C9*11 polymorphism on (S)-warfarin metabolism. Methods results The *11 allele that in mutation Arg335→Trp occurred with a frequency ∼1% Caucasian African-American populations. Four subjects carrying *1/*11 genotype were identified clinical cohort 192 warfarin patients. Compared to control (n=127), group exhibited 33% reduction maintenance dose, was independent study population age or INR. In-vitro studies directed towards...
Immunoglobulin light chains are low-molecular-weight proteins filtered at the renal glomerulus and catabolized within proximal tubular epithelium. Excessive production urinary excretion of associated with dysfunction. They also interfere tubule epithelial functions in vitro. We studied binding 125I-labeled kappa- lambda-light chains, obtained from urine multiple myeloma patients, to rat human brush-border membranes. Light-chain brush borders was demonstrated immunologically by flow...
A previous genetic analysis comparing the Dahl salt-sensitive (S) rat with spontaneously hypertensive identified a major locus on chromosome 2 that influences proteinuria in S rat. In present study, blood pressure, proteinuria, and renal hemodynamics were evaluated congenic strains small segments of protective genome background. Proteinuria function significantly improved compared S. The causative interval was narrowed to <375 kb basis strains, haplotype data, comparative mapping,...
Studies suggest 24-h blood pressure (BP) variability has prognostic value for cardiovascular disease. Several factors associated with high BP are also common among individuals chronic kidney disease (CKD). We hypothesized would be higher versus without CKD.We analyzed 1,022 Jackson Heart Study participants who underwent ambulatory monitoring (ABPM). Twenty-four hour was defined by two metrics: day-night standard deviation (SDdn) and average real (ARV). CKD as ACR ≥ 30 mg/g or eGFR <60...
Hypertension prevalence varies between ethnic groups, possibly due to differences in genetic, environmental, and cultural determinants. Hispanic/Latino Americans are a diverse understudied population. We performed genome-wide association study (GWAS) of blood pressure (BP) traits 12,278 participants from the Hispanics Community Health Study/Study Latinos (HCHS/SOL). In discovery phase we identified eight previously unreported BP loci. replication stage, tested these loci 1982 Pelotas Birth...