A5101437911- Metabolomics and Mass Spectrometry Studies
- Genetic Associations and Epidemiology
- Signaling Pathways in Disease
- Insect-Plant Interactions and Control
- Lipid metabolism and disorders
- Aortic aneurysm repair treatments
- Lipid metabolism and biosynthesis
- Cell Adhesion Molecules Research
- Cancer, Lipids, and Metabolism
- Blood Coagulation and Thrombosis Mechanisms
- Vasculitis and related conditions
- Aortic Disease and Treatment Approaches
- Galectins and Cancer Biology
- Cancer-related molecular mechanisms research
- Infectious Aortic and Vascular Conditions
- Insect and Pesticide Research
- Chromatin Remodeling and Cancer
- Insect Resistance and Genetics
- Astrophysics and Cosmic Phenomena
- Gamma-ray bursts and supernovae
- Astrophysical Phenomena and Observations
- Acupuncture Treatment Research Studies
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- Heart Failure Treatment and Management
Second Hospital of Shanxi Medical University
2025
Shanxi Medical University
2025
Sun Yat-sen University
2025
China University of Mining and Technology
2025
Michigan United
2024
Chinese PLA General Hospital
2024
Guangxi Medical University
2017-2024
University of Michigan–Ann Arbor
2021-2024
Rochester General Hospital
2024
Shandong Academy of Agricultural Sciences
2021-2024
Objective— Oxidative stress and inflammation play key roles in the development of pulmonary arterial hypertension (PAH). Cyclophilin A (CypA) is secreted response to oxidative promotes cardiovascular disease. Endothelial cell (EC) dysfunction an early event pathogenesis PAH. We evaluated role extracellular CypA PAH compared effects acetylated (AcK-CypA, increased by stress) on EC dysfunction. Approach Results— In transgenic mice that express high levels specifically, a phenotype was observed...
Accurate, in-depth mapping of proteins on whole-tissue levels provides comprehensive insights into the spatially-organized regulatory processes/networks in tissues, but is challenging. Here we describe a micro-scaffold assisted spatial proteomics (MASP) strategy, based spatially-resolved micro-compartmentalization tissue using 3D-printed micro-scaffold, capable thousands across slice with excellent quantitative accuracy/precision. The pipeline includes robust precisely-preserved information,...
Aqueous zinc-ion batteries (AZIBs) have received considerable attention due to their advantages of being safe, environmentally friendly, and cost-effective.
Mendelian randomization harnesses genetic variants as instrumental variables to infer causal relationships between exposures and outcomes. However, certain can affect both the exposure outcome through a shared factor. This phenomenon, called correlated horizontal pleiotropy, may result in false-positive findings. Here, we propose Pleiotropic Clustering framework for randomization, PCMR. PCMR detects pleiotropy extends zero modal assumption enhance inference trait pairs with pleiotropic...
The triglyceride–glucose (TyG) index, an emerging surrogate marker of insulin resistance, has been implicated in adverse cardiovascular outcomes. However, its prognostic value critically ill patients with atrial fibrillation (AF) remains unclear. This study aimed to investigate the association between TyG index and all-cause mortality this high-risk population. We identified AF from Medical Information Mart for Intensive Care IV (MIMIC-IV) database categorized them into tertiles based on...
Aphis craccivora (Koch) is an economically important pest that affects legumes in worldwide. Chemical control still the primary efficient method for A. management. However, mechanism underlying insecticide resistance has not been elucidated. A previous study observed piperonyl butoxide (PBO) and diethyl maleate (DEM) significantly synergized imidacloprid field populations, indicating cytochrome P450 (P450) glutathione S-transferase (GST) genes may play pivotal roles resistance. In this...
Oxidative stress and inflammation play key roles in development of pulmonary arterial hypertension (PAH). We previously reported that an endothelial cell (EC)-specific cyclophilin A overexpression mouse developed many characteristics PAH. In other models cardiovascular disease, stimulates smooth muscle proliferation vascular inflammation, but mechanisms responsible for PAH have not been defined. particular, the contribution endothelial-to-mesenchymal transition A-mediated has studied....
A further investigation of the lipolysis induced by medium-chain triglyceride (MCT) was conducted on C57BL/6J mice fed with a diet containing 2% MCT or long-chain (LCT). Blood norepinephrine, body fat and blood lipid variables, protein mRNA expression genes relevant to were measured analyzed in white brown adipose tissue (WAT, BAT). Decreased improved profiles attributable confirmed. higher level norepinephrine observed diet. The lipase (ATGL) activity its expression, beta 3 adrenergic...
The spatiotemporal localization and expression of Dll4 are critical for sprouting angiogenesis. However, the related mechanisms poorly understood. Here, we show that G-protein-coupled receptor-kinase interacting protein-1 (GIT1) is a robust endogenous inhibitor Dll4-Notch1 signaling specifically controls stalk cell fate. GIT1 highly expressed in cells but not tip cells. deficiency remarkably enhances Notch1 signaling, resulting impaired retinal angiogenesis, which can be rescued by treatment...
Abdominal aortic aneurysm (AAA), although primarily asymptomatic, is potentially life-threatening as the rupture of AAA usually has a devastating outcome. Currently, there are several distinct experimental models AAA, each emphasizing different aspect in pathogenesis AAA. The elastase-induced model second most used rodent model. This involves direct infusion or application porcine pancreatic elastase (PPE) to infrarenal segment aorta. Due technical challenges, nowadays performed with...
Specific and efficient smooth muscle cell-targeted (SMC-targeted) gene deletion is typically achieved by pairing SMMHC-CreERT2-Tg mice with carrying the loxP-flanked gene. However, transgene, CreERT2, not controlled endogenous Myh11 promoter, codon-modified iCreERT2 exhibits significant tamoxifen-independent leakage. Furthermore, because Cre-bearing bacterial artificial chromosome (BAC) inserted onto Y chromosome, strain can only exhibit deletions in male mice. Additionally, there a lack of...
The fall armyworm, Spodoptera frugiperda, is a worldwide agricultural pest and causes huge losses of crop production each year. Tetraniliprole novel diamide insecticide with high efficacy against even the resistant pests Lepidoptera, Coleoptera, Diptera. MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at posttranscriptional level play an important regulatory role in resistance insects. However, effects miRNAs on tetraniliprole tolerance S. frugiperda poorly...
Atherosclerosis, a leading health concern, stems from the dynamic involvement of immune cells in vascular plaques. Despite its significance, interplay between chromatin remodeling and transcriptional regulation plaque macrophages is understudied. We discovered reduced expression Baf60a, component switch/sucrose non-fermentable (SWI/SNF) complex, advanced Myeloid-specific Baf60a deletion compromised mitochondrial integrity heightened adhesion, apoptosis, development. BAF60a preserves energy...
Constitutive or excessive activation of Toll-like receptor (TLR) signaling pathway can disrupt the body's immune tolerance to autoantigen, thus promoting development autoimmune disease. However, expression profile TLR in peripheral blood neutrophils pathogenesis microscopic polyangiitis (MPA) remains unclear. Thus, improved understanding pathobiology this disease may aid therapeutic targets for patients with MPA. In present study, we assessed pathway-related genes PCR array analysis was...
ABSTRACT Genetic variants within nearly 1,000 loci are known to contribute modulation of blood lipid levels. However, the biological pathways underlying these associations frequently unknown, limiting understanding findings and hindering downstream translational efforts such as drug target discovery. To expand our mechanisms controlling levels, we leverage a large multi-ancestry meta-analysis (N=1,654,960) lipids prioritize putative causal genes for 2,286 by combining six gene prediction...