A5014237355- Tryptophan and brain disorders
- Wastewater Treatment and Nitrogen Removal
- Anaerobic Digestion and Biogas Production
- Advanced Proteomics Techniques and Applications
- Stress Responses and Cortisol
- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Schizophrenia research and treatment
- Constructed Wetlands for Wastewater Treatment
- Neuroblastoma Research and Treatments
- Bipolar Disorder and Treatment
- Family Caregiving in Mental Illness
- Medicinal plant effects and applications
- Monoclonal and Polyclonal Antibodies Research
- Biological Activity of Diterpenoids and Biflavonoids
- Biofuel production and bioconversion
- Maternal Mental Health During Pregnancy and Postpartum
- Microbial Natural Products and Biosynthesis
- Microencapsulation and Drying Processes
- Ophthalmology and Visual Impairment Studies
- Biochemical and Molecular Research
- Zebrafish Biomedical Research Applications
- Health Literacy and Information Accessibility
- Social and Behavioral Studies
- TGF-β signaling in diseases
First Hospital of Jilin University
2025
Jilin University
2025
Affiliated Zhongshan Hospital of Dalian University
2024
University at Buffalo, State University of New York
2020-2024
Peking University
2016-2024
Beijing HuiLongGuan Hospital
2018-2024
Kazan Federal University
2024
Nanjing Agricultural University
2016-2023
University of Science and Technology of China
2023
China Medical University
2022
In both cancer and infections, diseased cells are presented to human Vγ9Vδ2 T through an 'inside out' signalling process whereby structurally diverse phosphoantigen (pAg) molecules sensed by the intracellular domain of butyrophilin BTN3A11-4. Here we show how-in humans alpaca-multiple pAgs function as 'molecular glues' promote heteromeric association between domains BTN3A1 similar BTN2A1. X-ray crystallography studies visualized that engagement with forms a composite interface for direct...
During two-phase sludge anaerobic digestion, is usually hydrolyzed and acidified in the first phase, then methane produced second stage. To get more from sludge, most studies literature focused on increase of hydrolysis. In this paper a different pretreatment method, i.e., pretreating at pH 10 for 8 d reported, by which both waste activated hydrolysis acidification were increased, production was significantly improved. First, effect methods yield compared. The pretreated showed highest...
In this study an efficient strategy, i.e., controlling the fermentation pH at constant 10, for significantly increasing hydrogen yield from waste activated sludge (WAS) via improvement of anaerobic process (sludge solubilization, hydrolysis, and acidification) inhibition consumption by acetobacteria was reported. Without addition pure producer nutrient source, effect different in range 4−11 on production WAS compared with that initial pH. The maximal observed respectively 10 but former 47.8%...
The increasing use of copper nanoparticles (Cu NPs) raises concerns about their potential toxic effects on the environment. However, influences wastewater biological nutrient removal (BNR) and nitrous oxide (N(2)O) generation in activated sludge process have never been documented. In this study long-term Cu NPs (0.1-10 mg/L) BNR N(2)O were investigated. total nitrogen (TN) was enhanced reduced at any levels investigated, but both ammonia phosphorus removals not affected. mechanism studies...
This paper reported an efficient method to significantly reduce nitrous oxide (N2O) and nitric (NO) generation in anaerobic−aerobic (low dissolved oxygen) processes. It was found that by the use of waste-activated sludge alkaline fermentation liquid as synthetic wastewater−carbon source, compared with commonly used carbon source literature (e.g., acetic acid), N2O NO reduced 68.7% 50.0%, respectively, but removal efficiencies total phosphorus (TP) nitrogen (TN) were improved. Both produced...
A new and tri-responsive fluorescent Schiff base probe (DBAB) has been designed developed for the recognition of iron(<sc>iii</sc>) ions (Fe<sup>3+</sup>), iron(<sc>ii</sc>) (Fe<sup>2+</sup>) copper(<sc>ii</sc>) (Cu<sup>2+</sup>) simultaneously.
Abstract Background Ischemic stroke is a serious cerebrovascular disease with high morbidity and disability. Zinc accumulation has been shown to play vital role in neuronal death blood–brain barrier damage following ischemia acute stage. However, almost nothing known about whether zinc involved neurological recovery ischemic prolonged period. This study investigates promotes through astrocytes‐induced angiogenesis during repair phase. Methods Sprague–Dawley rats were subjected 2 h...
Most of the studies on sewage sludge treatment in literature were conducted for methane generation under acidic or near neutral pH conditions. It was reported our previous that accumulation short-chain fatty acids (SCFAs), preferred carbon source biological wastewater nutrient removal, significantly enhanced when fermented alkaline conditions, but optimal temperature-dependent (pH 10 at ambient temperature, 9 mesophilic, and 8 thermophilic), maximal SCFAs yields following order: thermophilic...
Objective: Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte (MLR), and platelet-to-lymphocyte (PLR) have been used as markers of inflammation in mental illness. However, these indices not widely schizophrenia research Chinese participants. Our aim was to use ratios explore the relationship between inflammation. Methods: In this retrospective cross-sectional study, we collected total blood cell counts 549 patients with 930 healthy controls at Beijing Huilongguan Hospital October...
Accurate, in-depth mapping of proteins on whole-tissue levels provides comprehensive insights into the spatially-organized regulatory processes/networks in tissues, but is challenging. Here we describe a micro-scaffold assisted spatial proteomics (MASP) strategy, based spatially-resolved micro-compartmentalization tissue using 3D-printed micro-scaffold, capable thousands across slice with excellent quantitative accuracy/precision. The pipeline includes robust precisely-preserved information,...
Evidence suggest immunity abnormalities and inflammation might play an important role in the pathophysiology of depression. This study explored relationship between depression using neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte (MLR), platelet-to-lymphocyte (PLR), systemic immune-inflammation index (SII) as inflammatory markers.We collected full blood count results 239 patients with 241 healthy controls. Patients were divided into three diagnostic subtype groups: severe...
Accumulating evidence suggested that immune system activation might be involved in the pathophysiology of schizophrenia. The neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte (MLR), platelet/lymphocyte (PLR) and systemic immune-inflammation index (SII) can measure inflammation. This study aimed to investigate inflammatory state patients with schizophrenia by using these indicators.
Fmb60 is a wild-type Bacillus subtilis isolated from compost with significant broad-spectrum antimicrobial activities. Two novel PKS clusters were recognized in the genome sequence of fmb60, and then three polyene antibiotics, aurantinins B, C, D, 1-3, obtained by bioactivity-guided isolation fermentation fmb60. The structures B-D elucidated LC-HRMS NMR data analysis. Aurantinins C D identified as new compounds. showed activity against multidrug-resistant Staphylococcus aureus Clostridium...
Lincomycin is one of the most important antibiotics in clinical practice. To further understand regulatory mechanism on lincomycin biosynthesis, we investigated a pleiotropic transcriptional regulator AdpAlin producer S. lincolnensis NRRL 2936. Deletion adpAlin (which generated ΔadpAlin) interrupted biosynthesis and impaired morphological differentiation. We also found that putative AdpA binding sites were unusually scattered promoters all 8 operons biosynthetic gene cluster (BGC). In...
<title>Abstract</title> <bold>Background</bold> Numerous studies have demonstrated that exosomal microRNAs (miRNAs) are closely associated with the pathological mechanisms underlying various infectious diseases, including brucellosis. Concurrently, macrophage polarization has been identified as a critical factor in pathogenesis of However, question whether can regulate and thereby contribute to brucellosis remains unresolved. Our study investigates role miR-let-7e-5p Rictor/AKT1 signaling...
Fructus ligustri Lucidi (FLL) is the fruit of Ligustrum lucidum Ait and a traditional Chinese medicine, primarily known for its role in osteoporosis prevention treatment. The present study aimed to elucidate effect underlying mechanism action ethanol extract FLL on osteoclast differentiation bone resorption, identify active compounds within it. RAW264.7 murine monocyte/macrophage cells were stimulated with receptor activator nuclear factor κB ligand (RANKL) induce vitro. demosntrated that...