A5012728386- Infrastructure Maintenance and Monitoring
- Structural Engineering and Vibration Analysis
- Wave and Wind Energy Systems
- Biomimetic flight and propulsion mechanisms
- Geotechnical Engineering and Underground Structures
- GNSS positioning and interference
- Soft Robotics and Applications
- Angiogenesis and VEGF in Cancer
- Drilling and Well Engineering
- Insect Pheromone Research and Control
- Advanced Surface Polishing Techniques
- Neurobiology and Insect Physiology Research
- Concrete Corrosion and Durability
- Tribology and Lubrication Engineering
- Robot Manipulation and Learning
- Ionosphere and magnetosphere dynamics
- Fluid Dynamics and Turbulent Flows
- Advanced Thermodynamics and Statistical Mechanics
- Functional Brain Connectivity Studies
- Geophysical Methods and Applications
- Microwave Imaging and Scattering Analysis
- PI3K/AKT/mTOR signaling in cancer
- Ocean Waves and Remote Sensing
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Mechanics and Biomechanics Studies
Chiba University
2017-2024
Tongji University
2004-2023
Shanghai Tenth People's Hospital
2016-2023
Bauman Moscow State Technical University
2021
University of Kansas
2020
China Academy of Railway Sciences
2019
Chongqing University
2019
Tongji Hospital
2018
Chinese Academy of Sciences
2015-2017
Shenyang Institute of Automation
2015-2017
Bridge displacement is the most basic evaluation index of health status a bridge structure. The existing measurement methods for basically fail to realize long-term and real-time dynamic monitoring structures, because low degree automation insufficient precision, causing bottlenecks restriction. To solve this problem, we proposed system based on laser projection-sensing technology. First, spot recognition method was studied. Second, software developed. Finally, series experiments using were...
To detect changes in brain lateralization patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) using resting-state functional magnetic resonance imaging (fMRI).Data from 61 well-matched right-handed subjects were obtained the Disease Neuroimaging Initiative, including 19 healthy controls (HCs), 25 MCI, 17 AD. First, we divided 256 pairs of seed regions each hemisphere covering entire cerebral gray matter. Then, used intrinsic laterality index (iLI) approach to quantify...
Continuum robots present the great dexterity and compliance as dexterous manipulators to accomplish complex positioning tasks in confined anatomy during minimally invasive surgery. Tendon actuation is one of most popular approaches, which insert tendon eccentrically go through interact with flexible backbone compliant bends. However, hysteresis tip trajectory actuated (TA–DMs) has been observed loading unloading procedure, mainly caused by hindered friction at discrete interactions between...
Background: Recent studies have indicated that the default mode network (DMN) comprises at least three subsystems: The medial temporal lobe (MTL) and dorsal prefrontal cortex (DMPFC) subsystems a core comprising anterior MPFC (aMPFC) posterior cingulate (PCC). Additionally, disruption of DMN is related to Alzheimer's disease (AD). However, little known regarding changes in these AD, progressive characterized by memory impairment. Here, we performed resting-state functional connectivity (FC)...
Odours used by insects for foraging and mating are carried the air. Insects induce airflows around them flapping their wings, distribution of these may strongly influence odour source localisation. The flightless silkworm moth, Bombyx mori, has been a prominent insect model olfactory research. However, although there have numerous studies on antenna morphology its fluid dynamics, neurophysiology, localisation algorithms, airflow manipulation B. mori fanning not thoroughly investigated. In...
Clinical trials of Dll4 (Delta-like 4) neutralizing antibodies (Dll4nAbs) in cancer patients are ongoing. Surprisingly, pulmonary hypertension (PH) occurs 14% to 18% treated with Dll4nAbs, but the mechanisms have not been studied. Here, PH progression was measured mice Dll4nAbs. We detected Notch signaling lung tissues and analyzed vascular permeability inflammation. target gene array performed on adult human microvascular endothelial cells (ECs) after inhibiting cleavage. Similar were...
Numerous genome-wide association studies revealed that SNPs (single nucleotide polymorphisms) at the
S shape dexterous continuum manipulators (DCMs) are preferred in minimally invasive surgeries for better steerability towards a target and obstacles avoidance capability. Current ways of realizing shapes need to combine multi-bending segments which control the different segment separately. We propose cross-helical tendons actuated DCM that can realize just using one segment. With two pairs tendons, it omin-directional shapes, where types planar investigated this paper. A prototype with 8mm...
The spatiotemporal localization and expression of Dll4 are critical for sprouting angiogenesis. However, the related mechanisms poorly understood. Here, we show that G-protein-coupled receptor-kinase interacting protein-1 (GIT1) is a robust endogenous inhibitor Dll4-Notch1 signaling specifically controls stalk cell fate. GIT1 highly expressed in cells but not tip cells. deficiency remarkably enhances Notch1 signaling, resulting impaired retinal angiogenesis, which can be rescued by treatment...
Long-span cross-strait bridges extending into deep-sea waters are exposed to complex marine environments. During the construction stage, flexible freestanding bridge towers more vulnerable environmental loads imposed by wind and wave loads. This paper presents an experimental investigation on dynamic responses of a 389-m-high tower model in test facility with tunnel flume. An elastic geometric scale 1:150 was designed based Froude similarity tested under wind-only, wave-only wind-wave...
Vascular smooth muscle cell proliferation, migration, and dedifferentiation are critical for vascular diseases. Recently, it was demonstrated that Notch receptors have opposing effects on intima formation after vessel injury. Therefore, is important to investigate the specific regulatory pathways activate different receptors.There a time- dose-dependent activation of Notch1 by angiotensin II platelet-derived growth factor in cells. When phospholipase Cγ1 (PLCγ1) expression reduced small...
Bridges supported by abutments on rock or end-bearing piles are not expected to settle. However, sometimes approach embankments bridge settle due underlying compressible soil and/or traffic loading, causing bumps at the ends of bridges resulting from differential settlement between and embankments. Climatic conditions including temperature changes heavy rainfalls may also cause bumps. The seasonal change generates expansion contraction girders, which induce movements in backfill behind...
Notch1 activation mediated by γ-secretase is critical for angiogenesis. GeneCards database predicted that Caspase-4 (CASP4, with murine ortholog CASP11) interacts presenilin-1, the catalytic core of γ-secretase. Therefore, we investigated role CASP4/11 in angiogenesis.In vivo, studied Casp11 several angiogenesis mouse models using wild-type and knockout mice. In vitro, detected effects CASP4 on endothelial functions Notch signalling depleting or overexpressing human umbilical vein cells...
Pavement condition prediction plays a vital role in pavement maintenance. Many models and analyses have been conducted based on long-term data. However, the evaluation for road sections can hardly support daily routine This paper uses high-frequency distress data to explore relationship between initiation, weather, geometric factors. Firstly, framework is designed extract initial time of distress. Weather are integrated establish initiation dataset. Then, time-lag cross-correlation analysis...
Standard Kalman Filtering leads to divergence because of inaccurate system model and noise statistic. Researchers have taken relative studies about filtering optimization method. But now most are based on applications, such as integrated navigation system, so these methods lack general applicability. This paper starts from innovation-based adaptive estimation (IAE) memory attenuated (MA) filtering. These two optimized respective advantages disadvantages. We combined them create a new optimal...
Abstract Every-other-day fasting is effective for a variety of major human diseases, but the safety these interventions uncertain patients with spinal cord injury. A randomized controlled study was conducted to investigate every-other-day in Participants who met diagnostic inclusion and exclusion criteria were randomly divided into control groups. In group, lasted from 09:00 p . m on day 1 06:00 following (day 2). Dinner 2 restricted approximately 30% average daily calorie intake. The...
Dexterous continuum manipulators (DCMs) offer great potential for increasing instrument reach in minimally-invasive surgical procedures. We previously designed and fabricated a tendon driven DCM with large channel evenly distributed compliant joints skull base surgery the treatment of osteolysis during hip revision surgery. The joints, some cases, may limit lesion removal. In this paper, we propose finite element analysis (FEA) method optimizing distribution based on space requirements...