A5100342197- Cancer-related molecular mechanisms research
- Chinese history and philosophy
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- RNA modifications and cancer
- Aldose Reductase and Taurine
- X-ray Diffraction in Crystallography
- Cancer-related gene regulation
- Crystallization and Solubility Studies
- Circular RNAs in diseases
- Child and Adolescent Psychosocial and Emotional Development
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- China's Ethnic Minorities and Relations
- Immune Response and Inflammation
- Bone Metabolism and Diseases
- Lignin and Wood Chemistry
- Viral-associated cancers and disorders
- Advanced Glycation End Products research
- Biochemical effects in animals
- Immune cells in cancer
- Chemotherapy-induced organ toxicity mitigation
- Prenatal Substance Exposure Effects
- Proteoglycans and glycosaminoglycans research
- HIV-related health complications and treatments
Shanghai Normal University
2023-2024
University of Rochester
2018-2023
Rangsit University
2023
University of Rochester Medical Center
2022-2023
Command Hospital
2023
Chongqing Medical University
2022
China Medical University
2022
Shanxi Medical University
2021
First Hospital of Shanxi Medical University
2021
Shandong First Medical University
2021
<h3>Background</h3> Chemotherapy combined with immunotherapy becomes the main trend in lung cancer intervention; however, how chemotherapy promotes immune function remains elusive. Therefore, we sought to determine function. <h3>Methods</h3> We determined 100 NSCLC patients expression of CD8, functional markers (IFN-γ, Granzyme B, and Perforin) specific chemokines by quantitative real-time reverse transcriptase-PCR. Functional experiments were carried out check whether docetaxel (DOC), a...
Significance Sex ratio is an important indicator of reproductive health, and its skewing reflects disturbed embryonic development. This study focused on sex skewing, which has recently identified in human vitro fertilization (IVF) babies. We reported herein that the skewed mouse IVF offspring was due to impaired imprinted X chromosome inactivation via suppressing ring finger protein 12 ( Rnf12 )/X-inactive specific transcript Xist ) pathway; can be corrected by overexpressing or...
// Shumin Wang 1, 2 , Yingxi Mo Kaoru Midorikawa 1 Zhe Zhang Guangwu Huang Ning Ma 3 Weilin Zhao Yusuke Hiraku Shinji Oikawa Mariko Murata Department of Environmental and Molecular Medicine, Mie University Graduate School Tsu, Mie, Japan Otolaryngology Head Neck Surgery, First Affiliated Hospital Guangxi Medical University, Nanning, Guangxi, China Faculty Nursing Science, Suzuka Suzuka, Correspondence to: Murata, e-mail: mmurata@doc.medic.mie-u.ac.jp Keywords: nasopharyngeal carcinoma,...
Carbon nanotube (CNT) is used for various industrial purposes, but exhibits carcinogenic effects in experimental animals. Chronic inflammation the respiratory system may participate CNT-induced carcinogenesis. 8-Nitroguanine (8-nitroG) a mutagenic DNA lesion formed during inflammation. We have previously reported that multi-walled CNT (MWCNT) induced 8-nitroG formation lung epithelial cells and this process involved endocytosis. To clarify mechanism of carcinogenesis, we examined role...
Abstract Objectives Microvesicles (MVs) derived from human Wharton’s jelly mesenchymal stem cells (MSC-MVs) were demonstrated to ameliorate acute lung injury (ALI). We have previously found that MSC-MV-transferred hepatocyte growth factor was partly involved in their therapeutic effects. Since MSC-MVs also contained a substantial quantity of miR-100, which plays an important role cancer and injury, we speculated miR-100 might similarly account for part the effects MSC-MVs. Methods MSCs...
Abstract Adenosine (A) to inosine (I) RNA editing catalyzed by adenosine deaminases acting on (ADAR) enzymes is a post-transcriptional modification that emerged as key player in tumorigenesis and cancer progression. Antizyme inhibitor 1 (AZIN1) one of the most frequent A-to-I alterations many human cancers. RNA-edited AZIN1 known confer gain-of-function phenotype associated with aggressive tumors. However, functional impact angiogenesis remains unexplored. We showed here promoted tumor...
Abstract Background Epigenetic silencing of tumor suppressor genes play important roles in NPC tumorgenesis. Tissue factor pathway inhibitor-2 (TFPI-2), is a protease inhibitor. Recently, TFPI-2 was suggested to be gene involved tumorigenesis and metastasis some cancers. In this study, we investigated whether inactivated epigenetically nasopharyngeal carcinoma (NPC). Methods Transcriptional expression levels evaluated by RT-PCR. Methylation status were methylation specific PCR bisulfate...
Nasopharyngeal carcinoma (NPC) is a malignancy of the head and neck that prevalent in Southeast Asia southern China. Recent studies epigenetics suggest DNA methylation plays pivotal role onset progression cancer. Combining methyl-DNA binding domain capture technique cDNA microarray analysis, we identified unique hypermethylated gene, RERG (Ras-like estrogen-regulated growth inhibitor), was down-regulated NPC tissues. tumor suppressor gene first reported breast However, functions are largely...
// Xiaoying Zhou 1, 2, * , Jiazhang Wei Fu Chen 3 Xue Xiao 1 Tingting Huang Qian He Shumin Wang Chunping Du Yingxi Mo 4 Longde Lin 5 Ying Xie Lili Lan Mairiko Murata Guangwu Ingemar Ernberg 2 Liudmila Matskova Zhe Zhang Department of Otolaryngology-Head & Neck Surgery, First Affiliated Hospital Guangxi Medical University, Guangxi, China Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden Radiation Oncology, Eye Ear Nose Throat Fudan Shanghai, Environmental Molecular...
Cytochrome b5 reductase 2 (CYB5R2), a member of the flavoprotein pyridine nucleotide cytochrome family, is associated with number physiological reactions. However, its role in cancer, especially nasopharyngeal carcinoma (NPC), has not been addressed. Here, we investigate transcript levels and promoter methylation status CYB5R2 NPC derived cell lines tumor biopsies experimentally address as suppressor gene. We find that are decreased biopsies. Promoter hypermethylation was detected all six...
Nasopharyngeal carcinoma (NPC) is one of the most prevalent malignant tumors with poor prognosis in Southern China and Southeast Asia. Angiogenesis-related molecules can be promising therapeutic targets NPC. To investigate relationships cancer-associated fibroblasts (CAFs) chemokine-related neoangiogenesis, we compared immunohistochemical analyses alpha-smooth-muscle actin ( α -SMA), stroma-derived factor-1 (SDF-1), its receptor CXCR4 primary NPC specimens chronic nasopharyngitis tissues. In...
Follistatin like-1 (FSTL1) is a secreted glycoprotein involved in series of physiological and pathological processes. However, its contribution to the development cancer, especially pathogenesis nasopharyngeal carcinoma (NPC), remains be elucidated. We aimed investigate dysregulation FSTL1 possible function NPC. was frequently downregulated NPC cell lines primary tumor biopsies by promoter hypermethylation. Ectopic expression significantly suppressed colony formation, proliferation,...
Epigenetic changes, including DNA methylation, disrupt normal cell function, thus contributing to multiple steps of carcinogenesis. Nasopharyngeal carcinoma (NPC) is endemic in southern China and highly associated with Epstein-Barr virus (EBV) infection. Significant changes the host methylome are observed EBV-associated NPC cancer development. marks for diagnosis urgently needed. In order explore methylation marks, we investigated candidate genes nasopharyngeal carcinoma. We first employed...
The ability to simultaneously modulate a set of genes for lineage-specific development has made miRNA an ideal master regulator organogenesis. However, most deletions do not exhibit obvious phenotypic defects possibly due functional redundancy. miRNAs are known regulate skeletal lineages as the loss their maturation enzyme Dicer impairs bone remodeling processes. Therefore, it is important identify specific essential homeostasis. We report MIR27a causing severe osteoporosis in mice. affects...
Numerous genome-wide association studies revealed that SNPs (single nucleotide polymorphisms) at the
Abstract The COVID-19 pandemic has had an inestimable impact worldwide, challenging the daily lives and interactions of children their families. In 2022, Shanghai implemented a three-month lockdown in response to acceleration positive cases during period. This restrictive policy provided insight into on children's social adjustment role parent–child conflict this process. Mothers preschool-aged participated study completed Chinese version Child-Parent Relationship Scale (CPRS) Strengths...
Nitrative and oxidative DNA damage plays an important role in inflammation-related carcinogenesis. To investigate the involvement of stem cells Epstein-Barr virus infection-related nasopharyngeal carcinoma (NPC), we used double immunofluorescence staining to examine several cancer stem/progenitor cell markers (CD44v6, CD24, ALDH1A1) NPC tissues lines. We also measured 8-nitroguanine formation as indicator lesions. The intensity was significantly higher inflammatory stroma than chronic...