A5043187857- Bone Metabolism and Diseases
- Immune Response and Inflammation
- Mitochondrial Function and Pathology
- Orthopedic Infections and Treatments
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Psoriasis: Treatment and Pathogenesis
- Trace Elements in Health
- Clostridium difficile and Clostridium perfringens research
- Bone health and treatments
University of Rochester
2023-2024
University of Rochester Medical Center
2021-2023
The ability to simultaneously modulate a set of genes for lineage-specific development has made miRNA an ideal master regulator organogenesis. However, most deletions do not exhibit obvious phenotypic defects possibly due functional redundancy. miRNAs are known regulate skeletal lineages as the loss their maturation enzyme Dicer impairs bone remodeling processes. Therefore, it is important identify specific essential homeostasis. We report MIR27a causing severe osteoporosis in mice. affects...
Abstract Interleukin-27 is a pleiotropic cytokine whose functions during bacterial infections remain controversial, and its role in patients with S. aureus osteomyelitis unknown. To address this knowledge gap, we completed clinical study observed elevated serum IL-27 levels (20-fold higher, P < 0.05) compared healthy controls. Remarkably, were 60-fold higher immediately following septic death than uninfected ( 0.05), suggesting pathogenic of IL-27. test hypothesis, evaluated WT IL-27Rα...
Age-related bone loss is associated with decreased formation, increased resorption and accumulation of marrow fat. During aging, differentiation potential stromal (a.k.a. mesenchymal stem) cells (BMSCs) shifted towards an adipogenic lineage away from osteogenic lineage. In aged tissue, we previously observed pathological opening the mitochondrial permeability transition pore (MPTP) which leads to dysfunction, oxidative phosphorylation uncoupling, cell death. Cyclophilin D (CypD) a protein...
Abstract The ability to simultaneously modulate a set of genes for lineage-specific development has made microRNA an ideal master regulator organogenesis. However, most deletions do not exhibit obvious phenotypic defects possibly due functional redundancy. MicroRNAs are known regulate skeletal lineages as the loss their maturation enzyme Dicer impairs bone remodeling processes. Therefore, it is important identify specific essential homeostasis. We report miR-27a causing severe osteoporosis...
Abstract Interleukin-27 is a pleiotropic cytokine whose reported functions during bacterial infections are debated as an area of active research. To address this, we investigated the role IL-27 signaling Staphylococcus aureus osteomyelitis. Clinically, observed elevated serum levels (20-fold higher, p<0.05) in patients with S. osteomyelitis compared to uninfected undergoing elective total joint replacement. Remarkably, immediately following septic death were 60-fold higher vs....