A5067033171- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- Nutritional Studies and Diet
- Viral-associated cancers and disorders
- Polyomavirus and related diseases
- Parvovirus B19 Infection Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Energy and Environment Impacts
- Occupational and environmental lung diseases
- Lipid metabolism and biosynthesis
- Cleft Lip and Palate Research
- Nutrition, Health and Food Behavior
- Nanoplatforms for cancer theranostics
- Lymphoma Diagnosis and Treatment
- Pediatric health and respiratory diseases
- Photodynamic Therapy Research Studies
- Ethics in Clinical Research
- Dermatology and Skin Diseases
- Mycobacterium research and diagnosis
- Tea Polyphenols and Effects
- Ubiquitin and proteasome pathways
- Folate and B Vitamins Research
- Traditional Chinese Medicine Analysis
- Cancer-related gene regulation
- Smoking Behavior and Cessation
University of Regina
2023
Tumor Hospital of Guangxi Medical University
2017-2022
Guangxi Medical University
2009-2017
Brigham and Women's Hospital
2016
The magnitude and patterns of associations between smoking risk nasopharyngeal carcinoma (NPC) in high-incidence regions remain uncertain. Associations with active passive tobacco were estimated using multivariate logistic regression a population-based case-control study 2,530 NPC cases 2,595 controls Guangdong Guangxi, southern China, 2010-2014. Among men, was significantly higher current smokers compared never (odds ratio (OR) = 1.32, 95% confidence interval (CI): 1.14, 1.53) but not...
To the authors' knowledge, no studies to date have explored familial risks of nasopharyngeal carcinoma (NPC) in detail and quantified its lifetime risk high-incidence populations.The authors conducted a population-based case-control study 2499 NPC cases 2576 controls randomly selected southern China from 2010 through 2014. Unconditional logistic regression was used estimate multivariable-adjusted odds ratios (ORs) with 95% confidence intervals (95% CIs) associated family history NPC. In...
Abstract Background Epigenetic silencing of tumor suppressor genes play important roles in NPC tumorgenesis. Tissue factor pathway inhibitor-2 (TFPI-2), is a protease inhibitor. Recently, TFPI-2 was suggested to be gene involved tumorigenesis and metastasis some cancers. In this study, we investigated whether inactivated epigenetically nasopharyngeal carcinoma (NPC). Methods Transcriptional expression levels evaluated by RT-PCR. Methylation status were methylation specific PCR bisulfate...
Serological detection of Epstein-Barr virus (EBV) antibodies is frequently used in nasopharyngeal carcinoma (NPC) mass screening. However, the large number seropositive subjects who require close follow-up still a big burden. The present study aimed to detect EBV load high-risk population for against EBV, as well examine whether assay DNA might reduce and improve early NPC. A prospective population-based cohort was conducted southern China from 2006 through 2013. Among 22,186 participants,...
// Xiaoying Zhou 1, 2, * , Jiazhang Wei Fu Chen 3 Xue Xiao 1 Tingting Huang Qian He Shumin Wang Chunping Du Yingxi Mo 4 Longde Lin 5 Ying Xie Lili Lan Mairiko Murata Guangwu Ingemar Ernberg 2 Liudmila Matskova Zhe Zhang Department of Otolaryngology-Head & Neck Surgery, First Affiliated Hospital Guangxi Medical University, Guangxi, China Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden Radiation Oncology, Eye Ear Nose Throat Fudan Shanghai, Environmental Molecular...
Epstein-Barr virus (EBV) reactivation from latent to lytic infection has been considered as a key step in nasopharyngeal carcinoma oncogenesis. However, epidemiological evidence regarding environmental risk factors for EBV on population level remains largely lacking. We enrolled 1916 randomly selected adults the general of Guangdong and Guangxi, China, 2010 2014. Information was collected via structured interview. Serum immunoglobulin A antibodies against viral capsid antigen nuclear 1 were...
// Weimin Ye 1 , Ellen T. Chang 2, 3 Zhiwei Liu Qing 4, 5 Yonglin Cai 6, 7 Zhe Zhang 8, 9 Guomin Chen 10 Qi-Hong Huang 11 Shang-Hang Xie Su-Mei Cao Jian-Yong Shao Wei-Hua Jia Yuming Zheng Jian Liao 12 Yufeng Longde Lin Liming Liang 13, 14 Ingemar Ernberg 15 Thomas L. Vaughan 16, 17 Guangwu 9, * Yi Zeng 10, Yi-Xin 5, 18, and Hans-Olov Adami 1, Department of Medical Epidemiology Biostatistics, Karolinska Institutet, Stockholm, Sweden 2 Exponent, Inc., Health Sciences Practice, Menlo Park, CA,...
BACKGROUND The potential role of occupational exposures in the development nasopharyngeal carcinoma (NPC) remains unclear, particularly high‐incidence areas. METHODS authors conducted a population‐based case‐control study, consisting 2514 incident NPC cases and 2586 randomly selected population controls, southern China from 2010 to 2014. Occupational history other covariates were self‐reported using questionnaire. Multivariate logistic regression was used estimate odds ratios (ORs) with 95%...
Given the role of exposures related to residence in development nasopharyngeal carcinoma (NPC) has not been well explored, present study aims investigate magnitude and pattern associations for NPC with lifelong residential exposures. We carried out a multi-center, population-based case-control 2533 incident cases 2597 randomly selected population controls southern China between 2010 2014. performed multivariate logistic regression estimate odds ratios (ORs) 95% confidence intervals (CIs)...
Because persistent inflammation may render the nasopharyngeal mucosa susceptible to carcinogenesis, chronic ear-nose-throat (ENT) disease and its treatment might influence risk of carcinoma (NPC). Existing evidence is, however, inconclusive often based on methodologically suboptimal epidemiologic studies. In a population-based case-control study in southern China, we enrolled 2,532 persons with NPC 2,597 controls, aged 20–74 years, from 2010 2014. Odds ratios were estimated for associations...
Background An association between a nonmedicinal herbal diet and nasopharyngeal carcinoma (NPC) has often been hypothesized but never thoroughly investigated. Methods This study enrolled total of 2469 patients with incident NPC 2559 population controls from parts Guangdong Guangxi Provinces in southern China 2010 2014. Questionnaire information was collected on the intake traditional tea soup as well specific plants used soups other potentially confounding lifestyle factors. Multivariate...
Dietary factors, such as consumption of preserved foods, fresh vegetables, and fruits, have been linked to the risk nasopharyngeal carcinoma (NPC). However, little is known about associations between dietary patterns NPC in NPC-endemic areas. We aimed evaluate whether are associated with risk. studied 2554 newly diagnosed patients aged 20-74 y living 3 endemic regions southern China, 2648 population-based controls frequency-matched case by age, sex, region, 2010 2014. components were derived...
Whether the association between body size or shape and nasopharyngeal carcinoma (NPC) risk exists varies by age-specific indicators is unclear. In a population-based case-control study conducted in Southern China 2010 2014, self-reported height, weight, at age 20 10 years before interview were collected from 2448 histopathologically confirmed NPC cases 2534 controls. Body mass index (BMI) was categorized according to World Health Organization guidelines for Asian populations: underweight...
The potential effect of alcohol or tea intake on the risk nasopharyngeal carcinoma (NPC) remains controversial.In a population-based case-control study in southern China, we assessed from 2,441 histopathologically confirmed NPC cases and 2,546 controls. We calculated mean daily ethanol (g/day) (mL/day). Fully adjusted ORs with 95% confidence intervals (CI) were estimated using logistic regression; dose-response trends evaluated restricted cubic spline analysis.Compared nondrinkers, no...
Abstract Background Atopic dermatitis ( AD ) is a major public health concern worldwide. Given its rising prevalence, there pressing need to study epidemiology. To date, no validated, cost‐effective, and patient self‐administered screening instrument exists that can reliably distinguish from other skin conditions. Our aim develop an validate self‐reported diagnosis quickly with reasonable accuracy in population at distance. Methods A one‐page, 13‐question atopic evaluation questionnaire...
Assisting smoking parents to quit and eliminating the secondhand smoke (SHS) exposure of their children is a global health priority. Engaging healthcare workers in developing countries address this priority has been challenge. This study intends explore issues around current practice related SHS assessment counseling identify barriers reduction Chinese pediatric setting.We conducted qualitative interviews (11 focus groups discussions (FGDs) with pediatricians, 6 FGDs nurses 11 in-depth...
Subjects with elevated Epstein-Barr virus (EBV) immunoglobulin A (IgA) titers have a higher risk of developing nasopharyngeal carcinoma (NPC), indicating that reactivation EBV in the local mucosa might be important for NPC carcinogenesis. Cigarette smoking appears to one environmental factors NPC. However, it remains unclear whether smoking-induced carcinogenesis acts through reactivating mucosa. Therefore, this study aims investigate association between cigarette and high-risk population....