A5036993838- Carcinogens and Genotoxicity Assessment
- Genomics, phytochemicals, and oxidative stress
- DNA Repair Mechanisms
- Cancer-related molecular mechanisms research
- DNA and Nucleic Acid Chemistry
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Cancer-related gene regulation
- Glutathione Transferases and Polymorphisms
- Free Radicals and Antioxidants
- Assisted Reproductive Technology and Twin Pregnancy
- Immune cells in cancer
- Drug Transport and Resistance Mechanisms
- Trace Elements in Health
- Head and Neck Cancer Studies
- Cancer Cells and Metastasis
- Noise Effects and Management
- Metal complexes synthesis and properties
- Bioactive Compounds and Antitumor Agents
- Viral-associated cancers and disorders
- Alzheimer's disease research and treatments
- Inflammatory Biomarkers in Disease Prognosis
- Circular RNAs in diseases
Mie University
2016-2025
Suzuka University of Medical Science
2006-2025
Fukuoka University Hospital
2019
Osaka International Cancer Institute
2012-2016
Kyushu University
2016
Fuji Women's University
2013
Kyoto University
1998-2008
Keio University
2004
Gifu Pharmaceutical University
2004
University of Shimane
2004
Objectives: Alzheimer’s disease (AD) is the most common cause of dementia in elderly persons. Since pathology AD develops slowly from a preclinical or early phase into fully expressed clinical syndrome, at time diagnosis has been progressing for many years. To facilitate AD, we performed protein profiling blood patients with mild as defined by Functional Assessment Staging (FAST) scale.Methods: Plasma samples and healthy controls were analyzed using two-dimensional differential gel...
Recent intervention studies revealed that β-carotene supplement to smokers resulted in a higher incidence of lung cancer. However, the causal mechanisms remain be clarified. We reported here vitamin A (retinol) and its derivative (retinal) caused cellular DNA cleavage detected by pulsed field gel electrophoresis. Retinol retinal significantly induced 8-oxo-7,8-dihydro-2′-deoxyguanosine formation HL-60 cells but not H2O2-resistant HP100 cells, suggesting involvement H2O2 damage. Experiments...
Early B cell factor 1 (EBF1) is a transcription involved in the differentiation of several stem lineages and it negative regulator estrogen receptors. EBF1 down-regulated many tumors, believed to play suppressive roles cancer promotion progression. However, functional carcinogenesis are unclear. Liver fluke-infection-associated cholangiocarcinoma (CCA) an oxidative stress-driven bile duct epithelium. In this study, we investigated expression tissues from CCA patients, lines (KKU-213, KKU-214...
Abstract Alzheimer’s disease (AD), a chronic neurodegenerative disorder, is the leading cause of dementia. Over-activated microglia related to amyloid-beta (Aβ) and phosphorylated tau (phospho-tau) accumulation in AD brain. Taurine an amino acid with multiple physiological functions including anti-inflammatory effects, has been reported be neuroprotective AD. However, role taurine microglia-mediated remains unclear. Here, we examined effects on brains senescence-accelerated mouse prone 8...
DNase I footprinting has revealed that zinc(II) complexes with macrocyclic tetraamines (1,4,7,10-tetraazacyclododecane,cyclen) appended one or two aryl-methyl group(s), ((9-acridinyl)methyl-, (4-quinolyl)methyl-, 1,7-bis(4-quinolyl)methyl-, (1-naphthyl)methyl-, and 1,7-bis(1-naphthyl)methyl-cyclen) selectively bind to native double-stranded DNA (150 base pairs), at AT-rich regions like classical minor groove binders (distamycin A 4,6-diamidino-2-phenylindole (DAPI)). The selectivity affinity...
Oral lichen planus (OLP) is a chronic inflammatory disease, which has been clinically associated with development to oral cancer. A double immunofluorescence labeling study found that 8‐nitroguanine and 8‐oxo‐7,8‐dihydro‐2′‐deoxyguanosine (8‐oxodG) accumulated in epithelium OLP squamous cell carcinoma (OSCC) biopsy specimens, whereas little or no immunoreactivity was observed normal mucosa. Colocalization of inducible nitric oxide synthase (iNOS) OSCC. Immunoreactivity 3‐nitrotyrosine,...
There is currently much interest in the possibility that dietary antioxidants may confer protection from certain diseases, such as atherosclerosis and cancer. The importance of α-tocopherol (vitamin E) a biological antioxidant widely recognized. However, pro-oxidant properties have been observed chemical systems, it has reported vitamin can induce tumor formation act complete promotor laboratory animals. In present communication, we find potent DNA-damaging agent presence copper(II) ions,...
The soy isoflavones, genistein (5,7,4'-trihydroxyisoflavone) and daidzein (7,4'-dihydroxyisoflavone), are representative phytoestrogens that function as chemopreventive agents against cancers, cardiovascular disease, osteoporosis. However, recent studies indicated and/or induced cancers of reproductive organs in rodents, such the uterus vulva. To clarify molecular mechanisms underlying induction carcinogenesis by we examined ability genistein, daidzein, their metabolites,...
Inflammation-mediated DNA damage triggered by Opisthorchis viverrini (OV) infection is a major risk factor of cholangiocarcinoma (CCA). We have recently reported that nitrative and oxidative participates in CCA development caused repeated with OV [Pinlaor et al., Carcinogenesis 2004; 25:1535-42]. Therefore, to clarify the preventive effect antihelminthic drug praziquantel against cholangiocarcinogenesis, we assessed this on damage, including formation 8-nitroguanine...
To clarify the association between oxidative DNA damage and neurotoxicity of arsenic, formation 8-hydroxy-2'-deoxyguanosine (8-OHdG) as an index in brain was examined mice fed with drinking water containing 1 or 2 ppm using HPLC-electrochemical detector immunohistochemical method. 8-OHdG levels were significantly increased given arsenic its immunoreactivity distributed cerebral cerebellar cortexes. Cerebral cortex neurons Purkinje cells showed degenerative changes accordance distribution...