Anuj Goel

ORCID: 0000-0003-2307-4021
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About
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Research Areas
  • Genetic Associations and Epidemiology
  • Metabolomics and Mass Spectrometry Studies
  • Genetic Mapping and Diversity in Plants and Animals
  • Genetic and phenotypic traits in livestock
  • Birth, Development, and Health
  • Congenital heart defects research
  • Bioinformatics and Genomic Networks
  • Atherosclerosis and Cardiovascular Diseases
  • RNA modifications and cancer
  • Cardiomyopathy and Myosin Studies
  • Nutrition, Genetics, and Disease
  • Diet, Metabolism, and Disease
  • Cancer-related molecular mechanisms research
  • Pancreatic function and diabetes
  • Lipoproteins and Cardiovascular Health
  • Epigenetics and DNA Methylation
  • Hormonal Regulation and Hypertension
  • Lipid metabolism and disorders
  • Cancer, Lipids, and Metabolism
  • Adipokines, Inflammation, and Metabolic Diseases
  • Alcohol Consumption and Health Effects
  • Adipose Tissue and Metabolism
  • Liver Disease Diagnosis and Treatment
  • Metabolism, Diabetes, and Cancer
  • Cholesterol and Lipid Metabolism

University of Oxford
2016-2025

Centre for Human Genetics
2016-2025

John Radcliffe Hospital
2012-2025

University of Cambridge
2017-2024

Reserve Bank of India
2024

British Heart Foundation
2018

Center for Non-Communicable Diseases
2017

University of Leicester
2017

University of Pennsylvania
2017

University College of Medical Sciences
2017

Josée Dupuis Claudia Langenberg Inga Prokopenko Richa Saxena Nicole Soranzo and 95 more Anne Jackson Eleanor Wheeler Nicole L. Glazer Nabila Bouatia‐Naji Anna L. Gloyn Cecilia M. Lindgren Reedik Mägi Andrew P. Morris Joshua C. Randall Toby Johnson Paul Elliott Denis Rybin Guðmar Þorleifsson Valgerður Steinthórsdóttir Peter Henneman Harald Grallert Abbas Dehghan Jouke‐Jan Hottenga C. Franklin Pau Navarro Kijoung Song Anuj Goel John R. B. Perry Josephine M. Egan Taina K. Lajunen Niels Grarup Thomas Sparsø Alex S. F. Doney Benjamin F. Voight Heather M. Stringham Man Li Stavroula Kanoni Peter Shrader Christine Cavalcanti-Proença Meena Kumari Lu Qi Nicholas J. Timpson Christian Gieger Katja K.H. Aben Ghislain Rocheleau Erik Ingelsson Ping An Jeffrey R. O’Connell Jian’an Luan Amanda Elliott Steven A. McCarroll Felicity Payne Rosa Maria Roccasecca François Pattou Praveen Sethupathy Kristin Ardlie Yavuz Ariyürek Beverley Balkau Philip J. Barter John Beilby Yoav Ben‐Shlomo Rafn Benediktsson Amanda J. Bennett Richard N. Bergman Murielle Bochud Eric Boerwinkle Amélie Bonnefond Lori L. Bonnycastle Knut Borch‐Johnsen Yvonne Böttcher Eric J. Brunner Suzannah J. Bumpstead G. Charpentier Yii‐Der Ida Chen Peter S. Chines Robert Clarke Lachlan Coin Matthew N. Cooper Marilyn C. Cornelis Gabe Crawford Laura Crisponi Ian N.M. Day Eco J. C. de Geus Jérôme Delplanque Christian Dina Michael R. Erdos Annette C. Fedson Antje Fischer-Rosinský Nita G. Forouhi Caroline S. Fox Rune R. Frants Maria Grazia Franzosi Pilar Galán Mark O. Goodarzi J. Graessler Christopher J. Groves Scott M. Grundy Rhian Gwilliam Ulf Gyllensten Samy Hadjadj

10.1038/ng.520 article EN Nature Genetics 2010-01-17
Panos Deloukas Stavroula Kanoni Christina Willenborg Martin Farrall Themistocles L. Assimes and 95 more John R. Thompson Erik Ingelsson Danish Saleheen Jeanette Erdmann Benjamin A. Goldstein Kathleen Stirrups Inke R. König Jean‐Baptiste Cazier Åsa Johansson Alistair S. Hall Jong‐Young Lee Cristen J. Willer John C. Chambers Tõnu Esko Lasse Folkersen Anuj Goel Elin Grundberg Aki S. Havulinna Weang-Kee Ho Jemma C. Hopewell Niclas Eriksson Marcus E. Kleber Kati Kristiansson Per Lundmark Leo‐Pekka Lyytikäinen Suzanne Rafelt Dmitry Shungin Rona J. Strawbridge Guðmar Þorleifsson Emmi Tikkanen Natalie Van Zuydam Benjamin F. Voight Lindsay L. Waite Weihua Zhang Andreas Ziegler Devin Absher David Altshuler Anthony J. Balmforth Inês Barroso Peter S. Braund Christof Burgdorf Xueling Sim David Cox Maria Dimitriou Ron Do Alex S. F. Doney NourEddine El Mokhtari Per Eriksson Krista Fischer Pierre Fontanillas Anders Franco‐Cereceda Bruna Gigante Per‐Henrik Groop Stefan Gustafsson Jörg Hager Göran Hallmans Bok-Ghee Han Sarah Hunt Hyun Min Kang Thomas Illig Thorsten Kessler Joshua Knowles Genovefa Kolovou Johanna Kuusisto Claudia Langenberg Cordelia Langford Karin Leander Marja‐Liisa Lokki Anders Lundmark Mark I. McCarthy Christa Meisinger Olle Melander Evelin Mihailov Seraya Maouche Andrew D. Morris Martina Müller‐Nurasyid Kjell Nikus John F. Peden Nigel W. Rayner Asif Rasheed Silke Rosinger Deborah C. Rubin Moritz Rumpf Arne Schäfer Mohan U. Sivananthan Ci Song Alexandre F.R. Stewart Sian-Tsung Tan Guðmundur Þorgeirsson C. Ellen van der Schoot Peter J. Wagner George A. Wells Philipp S. Wild Tsun-Po Yang Philippe Amouyel

10.1038/ng.2480 article EN Nature Genetics 2012-12-02

An increased level of Lp(a) lipoprotein has been identified as a risk factor for coronary artery disease that is highly heritable. The genetic determinants the and their relevance are incompletely understood.We used novel gene chip containing 48,742 single-nucleotide polymorphisms (SNPs) in 2100 candidate genes to test associations 3145 case subjects with 3352 control subjects. Replication was tested three independent populations involving 4846 additional 4594 subjects.Three chromosomal...

10.1056/nejmoa0902604 article EN New England Journal of Medicine 2009-12-23
Christopher Newton‐Cheh Toby Johnson Vesela Gateva Martin D. Tobin Murielle Bochud and 95 more Lachlan Coin Samer S. Najjar Jing Hua Zhao Simon Heath S. Eyheramendy Konstantinos A. Papadakis Benjamin F. Voight Laura J. Scott Feng Zhang Martin Farrall Toshiko Tanaka Chris Wallace John C. Chambers Kay‐Tee Khaw Peter M. Nilsson Pim van der Harst Silvia Polidoro Diederick E. Grobbee N. Charlotte Onland‐Moret Michiel L. Bots Louise V. Wain Katherine S. Elliott Alexander Teumer Jian’an Luan Gavin Lucas Johanna Kuusisto Paul R. Burton David Hadley Wendy L. McArdle Matthew A. Brown Anna F. Dominiczak Stephen Newhouse Nilesh J. Samani John Webster Eleftheria Zeggini J. Beckmann Sven Bergmann Noha Lim Kijoung Song Péter Vollenweider Gérard Waeber Dawn Waterworth Xin Yuan Leif Groop Marju Orho‐Melander Alessandra Allione Alessandra Di Gregorio Simonetta Guarrera Salvatore Panico Fulvio Ricceri Valeria Romanazzi Carlotta Sacerdote Paolo Vineis Inês Barroso Manjinder S. Sandhu Robert Luben Gabriel Crawford Jari Lahti Markus Perola Michael Boehnke Lori L. Bonnycastle Francis S. Collins Anne Jackson Karen L. Mohlke Heather M. Stringham Timo T. Valle Cristen J. Willer Richard N. Bergman Mario A. Morken Angela Döring Christian Gieger Thomas Illig Thomas Meitinger Elin Org Arne Pfeufer H.‐Erich Wichmann Sekar Kathiresan Jaume Marrugat Christopher J. O’Donnell Stephen M. Schwartz David S. Siscovick Isaac Subirana Nelson B. Freimer Anna-Liisa Hartikainen Mark I. McCarthy Paul F. O’Reilly Leena Peltonen Anneli Pouta Paul E. de Jong Harold Snieder Wiek H. van Gilst Robert Clarke Anuj Goel Anders Hamsten John F. Peden

10.1038/ng.361 article EN Nature Genetics 2009-05-10
Sonja I. Berndt Stefan Gustafsson Reedik Mägi Andrea Ganna Eleanor Wheeler and 95 more Mary F. Feitosa Anne E. Justice Keri L. Monda Damien C. Croteau‐Chonka Felix R. Day Tõnu Esko Tove Fall Teresa Ferreira Davide Gentilini Anne Jackson Jian’an Luan Joshua C. Randall Sailaja Vedantam Cristen J. Willer Thomas W. Winkler Andrew R. Wood Tsegaselassie Workalemahu Yi‐Juan Hu Sang Lee Liming Liang Dan-Yu Lin Josine L. Min Benjamin M. Neale Guðmar Þorleifsson Jian Yang Eva Albrecht Najaf Amin Jennifer L. Bragg‐Gresham Gemma Cadby Martin den Heijer Niina Eklund Krista Fischer Anuj Goel Jouke‐Jan Hottenga Jennifer E. Huffman Ivonne Jarick Åsa Johansson Toby Johnson Stavroula Kanoni Marcus E. Kleber Inke R. König Kati Kristiansson Zoltán Kutalik Claudia Lamina Cécile Lecœur Li Guo Massimo Mangino Wendy L. McArdle Carolina Medina‐Gómez Martina Müller‐Nurasyid Julius S. Ngwa Ilja M. Nolte Lavinia Paternoster Sonali Pechlivanis Markus Perola Marjolein J. Peters Michael Preuß Lynda M. Rose Jianxin Shi Dmitry Shungin Albert V. Smith Rona J. Strawbridge Ida Surakka Alexander Teumer Mieke D. Trip Jonathan P. Tyrer Jana V. van Vliet‐Ostaptchouk Liesbeth Vandenput Lindsay L. Waite Wei Zhao Devin Absher Folkert W. Asselbergs Mustafa Atalay Antony Attwood Anthony J. Balmforth Hanneke Basart John Beilby Lori L. Bonnycastle Paolo Brambilla Marcel Bruinenberg Harry Campbell Daniel I. Chasman Peter S. Chines Francis S. Collins John Connell William Cookson Ulf dé Fairé Femmie de Vegt Mariano Dei Maria Dimitriou Sarah Edkins Karol Estrada David M. Evans Martin Farrall Maurizio Ferrario

10.1038/ng.2606 article EN Nature Genetics 2013-04-07
Ron Do Nathan O. Stitziel Hong‐Hee Won Anders Berg Jørgensen Stefano Duga and 88 more Pier Angelica Merlini Adam Kieżun Martin Farrall Anuj Goel Or Zuk I. Guella Rosanna Asselta Leslie A. Lange Gina M. Peloso Paul L. Auer Domenico Girelli Nicola Martinelli Deborah Farlow Mark A. DePristo Robert Roberts Alexandre F.R. Stewart Danish Saleheen John Danesh Stephen E. Epstein Suthesh Sivapalaratnam G. Kees Hovingh John J.P. Kastelein Nilesh J. Samani Heribert Schunkert Jeanette Erdmann Svati H. Shah William E. Kraus R. W. Davies Majid Nikpay Christopher T. Johansen Jian Wang Robert A. Hegele Eliana Hechter Winfried März Marcus E. Kleber Jie Huang Andrew D. Johnson Mingyao Li Greg Burke Myron D. Gross Yongmei Liu Themistocles L. Assimes Gerardo Heiss Ethan M. Lange Aaron R. Folsom Herman A. Taylor Oliviero Olivieri Anders Hamsten Robert Clarke Dermot F. Reilly Wu Yin Manuel A. Rivas Peter Donnelly Jacques E. Rossouw Bruce M. Psaty David M. Herrington James G. Wilson Stephen S. Rich Michael J. Bamshad Russell P. Tracy L. Adrienne Cupples Daniel J. Rader Muredach P. Reilly John A. Spertus Sharon Cresci Jaana Hartiala W.H. Wilson Tang Stanley L. Hazen Hooman Allayee Alex P. Reiner Christopher S. Carlson Charles Kooperberg Rebecca D. Jackson Eric Boerwinkle Eric S. Lander Stephen M. Schwartz David S. Siscovick Ruth McPherson Anne Tybjærg‐Hansen Gonçalo R. Abecasis Hugh Watkins Deborah A. Nickerson Diego Ardissino Shamil Sunyaev Christopher J. O’Donnell David Altshuler Stacey Gabriel Sekar Kathiresan

10.1038/nature13917 article EN Nature 2014-12-09

Genome-wide association studies have identified a region on chromosome 9p that is associated with coronary artery disease (CAD). The also type 2 diabetes (T2D), risk factor for CAD, although different SNPs were reported to be each in separate studies. We undertaken case–control study 4251 CAD cases and 4443 controls four European populations using previously (‘literature’) tagging SNPs. replicated the literature (P = 8×10−13; OR 1.29; 95% CI: 1.20–1.38) showed strong consistent detected by...

10.1093/hmg/ddm352 article EN cc-by-nc Human Molecular Genetics 2007-11-29
Loïc Yengo Sailaja Vedantam Eirini Marouli Julia Sidorenko Eric Bartell and 95 more Saori Sakaue Marielisa Graff Anders U. Eliasen Yunxuan Jiang Sridharan Raghavan Jenkai Miao Joshua Arias Sarah E. Graham Ronen E. Mukamel Cassandra N. Spracklen Xianyong Yin Shyh‐Huei Chen Teresa Ferreira Heather H Highland Yingjie Ji Tugce Karaderi Kuang Lin Kreete Lüll Deborah E. Malden Carolina Medina‐Gómez Moara Machado Amy Moore Sina Rüeger Xueling Sim Scott Vrieze Tarunveer S. Ahluwalia Masato Akiyama Matthew Allison Marcus Alvarez Mette K. Andersen Alireza Ani Vivek Appadurai Liubov Arbeeva Seema Bhaskar Lawrence F. Bielak Sailalitha Bollepalli Lori L. Bonnycastle Jette Bork‐Jensen Jonathan P. Bradfield Yuki Bradford Peter S. Braund Jennifer A. Brody Kristoffer Sølvsten Burgdorf Brian E. Cade Hui Cai Qiuyin Cai Archie Campbell Marisa Cañadas‐Garre Eulalia Catamo Jin Fang Chai Xiaoran Chai Li-Ching Chang Yi–Cheng Chang Chien-Hsiun Chen Alessandra Chesi Seung Hoan Choi Ren‐Hua Chung Massimiliano Cocca Maria Pina Concas Christian Couture Gabriel Cuéllar-Partida Rebecca Danning E. Warwick Daw Frauke Degenhard Graciela E. Delgado Alessandro Delitala Ayşe Demirkan Xuan Deng Poornima Devineni Alexander Dietl Maria Dimitriou Latchezar Dimitrov Rajkumar Dorajoo Arif B. Ekici Jorgen Engmann Zammy Fairhurst-Hunter Aliki‐Eleni Farmaki Jessica D. Faul Juan-Carlos Fernandez-Lopez Lukas Forer Margherita Francescatto Sandra Freitag‐Wolf Christian Fuchsberger Tessel E. Galesloot Yan Gao Zishan Gao Frank Geller Olga Giannakopoulou Franco Giulianini Anette P. Gjesing Anuj Goel Scott D. Gordon Mathias Gorski Jakob Grove Xiuqing Guo

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes

10.1038/s41586-022-05275-y article EN cc-by Nature 2022-10-12
Joshua C. Randall Thomas W. Winkler Zoltán Kutalik Sonja I. Berndt Anne Jackson and 95 more Keri L. Monda Tuomas O. Kilpeläinen Tõnu Esko Reedik Mägi Shengxu Li Tsegaselassie Workalemahu Mary F. Feitosa Damien C. Croteau‐Chonka Felix R. Day Tove Fall Teresa Ferreira Stefan Gustafsson Adam E. Locke Iain Mathieson André Scherag Sailaja Vedantam Andrew R. Wood Liming Liang Valgerður Steinthórsdóttir Guðmar Þorleifsson Emmanouil T. Dermitzakis Antigone S. Dimas Fredrik Karpe Josine L. Min Geoffrey C. Nicholson Deborah J. Clegg Thomas N. Person Jon P. Krohn Sabrina Bauer Christa Buechler Kristina Eisinger Amélie Bonnefond Philippe Froguel Jouke‐Jan Hottenga Inga Prokopenko Lindsay L. Waite Tamara B. Harris Albert V. Smith Alan R. Shuldiner Wendy L. McArdle Mark J. Caulfield Patricia B. Munroe Henrik Grönberg Yii-Der Ida Chen Li Guo J. Beckmann Toby Johnson Unnur Þorsteinsdóttir Maris Teder‐Laving Kay‐Tee Khaw Nicholas J. Wareham Wei Zhao Najaf Amin Ben A. Oostra Aldi T. Kraja Michael A. Province L. Adrienne Cupples Nancy L. Heard‐Costa Jaakko Kaprio Samuli Ripatti Ida Surakka Francis S. Collins Jouko Saramies Jaakko Tuomilehto Antti Jula Veikko Salomaa Jeanette Erdmann Christian Hengstenberg Christina Loley Heribert Schunkert Claudia Lamina H.-Erich Wichmann Eva Albrecht Christian Gieger Andrew A. Hicks Åsa Johansson Peter P. Pramstaller Sekar Kathiresan Elizabeth K. Speliotes Brenda W.J.H. Penninx Anna-Liisa Hartikainen Marjo‐Riitta Järvelin Ulf Gyllensten Dorret I. Boomsma Harry Campbell James F. Wilson Stephen J. Chanock Martin Farrall Anuj Goel Carolina Medina‐Gómez Fernando Rivadeneira Karol Estrada André G. Uitterlinden Albert Hofman M. Carola Zillikens

Given the anthropometric differences between men and women previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip waist-to-hip-ratio (133,723 individuals) took forward 348 SNPs into follow-up (additional 137,052 total 94 studies. Seven loci displayed significant (FDR<5%), including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA,...

10.1371/journal.pgen.1003500 article EN cc-by PLoS Genetics 2013-06-06

Ezetimibe lowers plasma levels of low-density lipoprotein (LDL) cholesterol by inhibiting the activity Niemann-Pick C1-like 1 (NPC1L1) protein. However, whether such inhibition reduces risk coronary heart disease is not known. Human mutations that inactivate a gene encoding drug target can mimic action an inhibitory and thus be used to infer potential effects drug.We sequenced exons NPC1L1 in 7364 patients with 14,728 controls without who were European, African, or South Asian ancestry. We...

10.1056/nejmoa1405386 article EN New England Journal of Medicine 2014-11-12

Exome sequencing studies in complex diseases are challenged by the allelic heterogeneity, large number and modest effect sizes of associated variants on disease risk presence numbers neutral variants, even phenotypically relevant genes. Isolated populations with recent bottlenecks offer advantages for studying rare as they have deleterious that present at higher frequencies well a substantial reduction variation. To explore potential Finnish founder population low-frequency (0.5–5%)...

10.1371/journal.pgen.1004494 article EN cc-by PLoS Genetics 2014-07-31
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