Sarah Parish
A5072077709- Lipoproteins and Cardiovascular Health
- Genetic Associations and Epidemiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Systems, Economic Evaluations, Quality of Life
- Cancer, Lipids, and Metabolism
- Blood Pressure and Hypertension Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Atherosclerosis and Cardiovascular Diseases
- Folate and B Vitamins Research
- Adipokines, Inflammation, and Metabolic Diseases
- Retinal Diseases and Treatments
- Cardiovascular Health and Risk Factors
- Heart Failure Treatment and Management
- Pharmaceutical Economics and Policy
- Eicosanoids and Hypertension Pharmacology
- Esophageal and GI Pathology
- Nutrition, Genetics, and Disease
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Inflammatory mediators and NSAID effects
University of Oxford
2016-2025
Medical Research Council
2016-2024
Nuffield Health
2016-2023
Royal North Shore Hospital
2023
MRC Population Health Research Unit
2016-2019
University of Virginia
2019
Queen Mary University of London
2019
Royal Prince Alfred Hospital
2019
Harvard University
2019
University of Edinburgh
2019
Lowering low-density lipoprotein cholesterol with statin therapy results in substantial reductions cardiovascular events, and larger may produce benefits. In rare cases, myopathy occurs association therapy, especially when the statins are administered at higher doses certain other medications.We carried out a genomewide study using approximately 300,000 markers (and additional fine-mapping) 85 subjects definite or incipient 90 controls, all of whom were taking 80 mg simvastatin daily as part...
An increased level of Lp(a) lipoprotein has been identified as a risk factor for coronary artery disease that is highly heritable. The genetic determinants the and their relevance are incompletely understood.We used novel gene chip containing 48,742 single-nucleotide polymorphisms (SNPs) in 2100 candidate genes to test associations 3145 case subjects with 3352 control subjects. Replication was tested three independent populations involving 4846 additional 4594 subjects.Three chromosomal...
BackgroundModerate alcohol intake has been associated with reduced cardiovascular risk in many studies, comparison abstinence or heavier drinking. Studies east Asia can help determine whether these associations are causal, since two common genetic variants greatly affect drinking patterns. We used to assess the relationships between and genotype-predicted mean men, contrasting findings men those women (few of whom drink).MethodsThe prospective China Kadoorie Biobank enrolled 512 715 adults...
<h3>Abstract</h3> <b>Objective:</b> To assess effects of intravenous streptokinase, one month oral aspirin, or both, on long term survival after suspected acute myocardial infarction. <b>Design:</b> Randomised, "2×2 factorial," placebo controlled trial. <b>Setting:</b> 417 hospitals in 16 countries. <b>Subjects:</b> 17 187 patients with infarction randomised between March 1985 and December 1987. Follow up vital status complete to at least 1 January 1990 for 95% all mid-1997 the 6213 United...
Blood lipids are established risk factors for myocardial infarction (MI), but uncertainty persists about the relevance of lipids, lipoprotein particles, and circulating metabolites MI stroke subtypes. This study sought to investigate associations plasma metabolic markers with risks incident MI, ischemic (IS), intracerebral hemorrhage (ICH). In a nested case-control (912 1,146 IS, 1,138 ICH cases, 1,466 common control subjects) 30 79 years age in China Kadoorie Biobank, nuclear magnetic...
OBJECTIVE Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, resistance, type 2 diabetes (T2D). Studies the processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS We have conducted meta-analysis genome-wide association tests ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) fasting in 10,701 nondiabetic adults...
Blood homocysteine levels are positively associated with cardiovascular disease, but it is uncertain whether the association causal.To assess effects of reducing folic acid and vitamin B(12) on vascular nonvascular outcomes.Double-blind randomized controlled trial 12,064 survivors myocardial infarction in secondary care hospitals United Kingdom between 1998 2008.2 mg plus 1 daily vs matching placebo.First major event, defined as coronary event (coronary death, infarction, or...
Elevated plasma homocysteine is a risk factor for Alzheimer disease, but the relevance of lowering to slow rate cognitive aging uncertain. The aim was assess effects treatment with B vitamins compared placebo, when administered several years, on composite domains function, global and aging. A meta-analysis conducted by using data combined from 11 large trials in 22,000 participants. Domain-based z scores (for memory, speed, executive function domain-composite score function) were available...
Background— Low-density lipoprotein (LDL) cholesterol and high-density (HDL) are established risk factors for vascular disease, but particle concentrations may be stronger determinants of risk. Methods Results— Associations between events baseline fractions, apolipoproteins B A 1 , particles assessed by nuclear magnetic resonance were considered in the Heart Protection Study randomized trial simvastatin versus placebo (>5000 during 5.3 years follow-up among 20 000 participants). Major...
<h3>Abstract</h3> <b>Objectives</b>: To assess the effects of cigarette smoking on incidence non-fatal myocardial infarction, and to compare tar in different types manufactured cigarettes. <b>Methods</b>: In early 1990s responses a postal questionnaire were obtained from 13926 survivors infarction (cases) recently discharged hospitals United Kingdom 32389 their relatives (controls). Blood had been cases soon after admission for index was also sought controls. 4923 6880 controls current...
Lowering LDL cholesterol reduces the risk of developing atherosclerotic events in CKD, but effects such treatment on progression kidney disease remain uncertain. Here, 6245 participants with CKD (not dialysis) were randomly assigned to simvastatin (20 mg) plus ezetimibe (10 daily or matching placebo. The main prespecified renal outcome was ESRD (defined as initiation maintenance dialysis transplantation). During 4.8 years follow-up, allocation resulted an average difference (SEM) 0.96 (0.02)...
Background: Genetic studies have shown lipoprotein(a) (Lp[a]) to be an important causal risk factor for coronary disease. Apolipoprotein(a) isoform size is the chief determinant of Lp(a) levels, but its impact on benefits therapies that lower remains unclear. Methods: HPS2-THRIVE (Heart Protection Study 2–Treatment HDL Reduce Incidence Vascular Events) a randomized trial niacin–laropiprant versus placebo background simvastatin therapy. Plasma levels at baseline and 1 year post-randomization...