Lasse Folkersen
A5031969480- Genetic Associations and Epidemiology
- Atherosclerosis and Cardiovascular Diseases
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
- Aortic aneurysm repair treatments
- Protease and Inhibitor Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Nutrition, Genetics, and Disease
- Rheumatoid Arthritis Research and Therapies
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Rare Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Aortic Disease and Treatment Approaches
- BRCA gene mutations in cancer
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Adipokines, Inflammation, and Metabolic Diseases
- RNA Research and Splicing
- Cardiac Valve Diseases and Treatments
- Chronic Lymphocytic Leukemia Research
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Genetic and phenotypic traits in livestock
Karolinska University Hospital
2011-2023
Karolinska Institutet
2013-2023
Technical University of Denmark
2015-2022
Lundbeck (Denmark)
2017-2022
Sankt Hans Hospital
2018-2021
Mental Health Services
2017-2021
Lundbeck Foundation
2017-2021
Roskilde Sygehus
2019
University of Copenhagen
2018-2019
Capital Region of Denmark
2017-2019
Tissue-resident memory T (Trm) cells form a heterogeneous population that provides localized protection against pathogens. Here, we identify CD49a as marker differentiates CD8+ Trm on compartmental and functional basis. In human skin epithelia, CD8+CD49a+ produced interferon-γ, whereas CD8+CD49a− interleukin-17 (IL-17). addition, from healthy rapidly induced the expression of effector molecules perforin granzyme B when stimulated with IL-15, thereby promoting strong cytotoxic response....
OBJECTIVE Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, resistance, type 2 diabetes (T2D). Studies the processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS We have conducted meta-analysis genome-wide association tests ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) fasting in 10,701 nondiabetic adults...
Circulating proteins have important functions in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted genome-wide protein quantitative trait locus (pQTL) study 91 plasma measured using the Olink Target platform 14,824 participants. We identified 180 pQTLs (59 cis, 121 trans). Integration pQTL data with eQTL disease association studies provided insight into pathogenesis, implicating lymphotoxin-α multiple sclerosis. Using...
Recent advances in highly multiplexed immunoassays have allowed systematic large-scale measurement of hundreds plasma proteins large cohort studies. In combination with genotyping, such studies offer the prospect to 1) identify mechanisms involved regulation protein expression plasma, and 2) determine whether are likely be causally implicated disease. We report here results genome-wide association (GWA) 83 considered relevant cardiovascular disease (CVD), measured 3,394 individuals multiple...
Background The NLR family, pyrin domain containing 3 ( NLRP 3) inflammasome is an interleukin IL )‐1β and ‐18 cytokine processing complex that activated in inflammatory conditions. role of the pathogenesis atherosclerosis myocardial infarction not fully understood. Methods Results Atherosclerotic plaques were analyzed for transcripts inflammasome, ‐1β release. Swedish First‐ever Infarction study Ac‐county FIA ) cohort consisting DNA from 555 patients 1016 healthy individuals was used to...
The predictive utility of polygenic scores is increasing, and many scoring methods are available, but it unclear which method performs best. This study evaluates the within a reference-standardized framework, uses common set variants reference-based estimates linkage disequilibrium allele frequencies to construct scores. Eight score were tested: p-value thresholding clumping (pT+clump), SBLUP, lassosum, LDpred1, LDpred2, PRScs, DBSLMM SBayesR, evaluating their performance predict outcomes in...
DNA variation analysis has become indispensable in many aspects of modern biomedicine, most prominently the comparison normal and tumor samples. Thousands samples are collected local sequencing efforts public databases requiring highly scalable, portable, automated workflows for streamlined processing. Here, we present nf-core/sarek 3, a well-established, comprehensive variant calling annotation pipeline germline somatic It is suitable any genome with known reference. We full rewrite...
Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality has significant heritability. We carried out genome-wide association discovery study 1866 patients with AAA 5435 controls replication promising signals (lead SNP p value < 1 × 10−5) in 2871 additional cases 32,687 performed further follow-up 1491 11,060 controls. In the study, nine loci demonstrated (p 10−5). sample, lead at one these loci, rs1466535, located within intron low-density-lipoprotein receptor-related...
Objective— Based on the emerging importance of wingless (Wnt) pathways in inflammation and vascular biology, we hypothesized a role for Dickkopf-1 (DKK-1), major modulator Wnt signaling, atherogenesis plaque destabilization. Methods Results— We report increased levels DKK-1 experimental (ApoE −/− mice) clinical (patients with coronary artery disease [n=80] patients carotid [n=47]) atherosclerosis, both systemically (serum) within lesion, particularly high advanced unstable disease....
Several genome-wide association studies have recently linked a group of single nucleotide polymorphisms in the 9p21 region with cardiovascular disease. The molecular mechanisms this link are not fully understood. We investigated five different expression microarray datasets order to determine if genotype had effect on any gene transcript aorta, mammary artery, carotid plaque and lymphoblastoid cells.After multiple testing correction, no genes were found relation rs2891168 risk genotype,...