Declan Bradley
A5080557082- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- COVID-19 and Mental Health
- Retinal Diseases and Treatments
- Complement system in diseases
- Influenza Virus Research Studies
- SARS-CoV-2 detection and testing
- Antibiotic Use and Resistance
- Animal Virus Infections Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Health disparities and outcomes
- Aortic aneurysm repair treatments
- Bacterial Infections and Vaccines
- COVID-19 and healthcare impacts
- Aortic Disease and Treatment Approaches
- Viral gastroenteritis research and epidemiology
- Zoonotic diseases and public health
- COVID-19 Pandemic Impacts
- Behavioral Health and Interventions
- Respiratory viral infections research
- Data-Driven Disease Surveillance
- Food Security and Health in Diverse Populations
- Delphi Technique in Research
Queen's University Belfast
2014-2024
Public Health Agency
2014-2024
Environmental Protection Agency
2019-2022
Queens University
2022
Royal Victoria Hospital
2011-2021
University of Ulster
2011-2021
La Trobe University
2006
Abstract Reports of ChAdOx1 vaccine–associated thrombocytopenia and vascular adverse events have led to some countries restricting its use. Using a national prospective cohort, we estimated associations between exposure first-dose or BNT162b2 vaccination hematological using nested incident-matched case-control study confirmatory self-controlled case series (SCCS) analysis. An association was found idiopathic thrombocytopenic purpura (ITP) (0–27 d after vaccination; adjusted rate ratio (aRR)...
BackgroundCurrent UK vaccination policy is to offer future COVID-19 booster doses individuals at high risk of serious illness from COVID-19, but it still uncertain which groups the population could benefit most. In response an urgent request Joint Committee on Vaccination and Immunisation, we aimed identify factors for severe outcomes (ie, COVID-19-related hospitalisation or death) in who had completed their primary schedule received first vaccine.MethodsWe constructed prospective cohorts...
Background: The BNT162b2 mRNA (Pfizer-BioNTech) and ChAdOx1 (Oxford-AstraZeneca) COVID-19 vaccines have demonstrated high efficacy against infection in phase 3 clinical trials are now being used national vaccination programmes the UK several other countries. There is an urgent need to study 'real-world' effects of these vaccines. aim our was estimate effectiveness first dose preventing hospital admissions.Methods: We conducted a prospective cohort using Early Pandemic Evaluation Enhanced...
Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality has significant heritability. We carried out genome-wide association discovery study 1866 patients with AAA 5435 controls replication promising signals (lead SNP p value < 1 × 10−5) in 2871 additional cases 32,687 performed further follow-up 1491 11,060 controls. In the study, nine loci demonstrated (p 10−5). sample, lead at one these loci, rs1466535, located within intron low-density-lipoprotein receptor-related...
The Delta (B.1.617.2) variant was the predominant UK circulating SARS-CoV-2 strain between May and December 2021. How infection compares with previous variants is unknown. This prospective observational cohort study assessed symptomatic adults participating in app-based COVID Symptom Study who tested positive for from 26 to July 1, 2021 (Delta overwhelmingly variant), compared (1:1, age- sex-matched) individuals presenting 28, 2020 6, (Alpha (B.1.1.7) variant). We illness (symptoms,...
Several countries restricted the administration of ChAdOx1 to older age groups in 2021 over safety concerns following case reports and observed versus expected analyses suggesting a possible association with cerebral venous sinus thrombosis (CVST). Large datasets are required precisely estimate between Coronavirus Disease 2019 (COVID-19) vaccination CVST due extreme rarity this event. We aimed accomplish by combining national data from England, Scotland, Wales.We created platforms consisting...
While population estimates suggest high vaccine effectiveness against SARS-CoV-2 infection, the protection for health care workers, who are at higher risk of exposure, is less understood.
We investigated the association between a wide range of comorbidities and COVID-19 in-hospital mortality assessed influence multi morbidity on risk COVID-19-related death using large, regional cohort 6036 hospitalized patients. This retrospective study was conducted Patient Administration System Admissions Discharges data. The International Classification Diseases 10th edition (ICD-10) diagnosis codes were used to identify common outcome measure. Individuals with lymphoma (odds ratio [OR],...
Abstract The emergence of the COVID-19 vaccination has been critical in changing course pandemic. To ensure protection remains high vulnerable groups booster vaccinations UK have targeted based on age and clinical vulnerabilities. We undertook a national retrospective cohort study using data from 2021 Census linked to electronic health records. fitted cause-specific Cox models examine association between conditions risk death all-other-cause for adults aged 50-100-years England vaccinated...
Enteroviruses are a common cause of seasonal childhood infections. The vast majority enterovirus infections mild and self-limiting, although neonates can sometimes develop severe disease. Myocarditis is rare complication infection. Between June 2022 April 2023, twenty cases neonatal enteroviral myocarditis caused by coxsackie B viruses were reported in the United Kingdom. Sixteen required critical care support two died. Enterovirus PCR on whole blood was most sensitive diagnostic test. We...
Since the end of November 2023, European Mortality Monitoring Network (EuroMOMO) has observed excess mortality in Europe. During weeks 48 2023–6 2024, preliminary results show a substantially increased rate 95.3 (95% CI: 91.7–98.9) all-cause deaths per 100,000 person-years for all ages. This is seen adults aged 45 years and older, coincides with widespread presence COVID-19, influenza respiratory syncytial virus (RSV) many countries during 2023/24 winter season.
Myopia is a complex trait affected by both genetic and environmental factors. High myopia associated with increased risk of sight threatening eye disorders such as retinal detachment. The purpose this genome-wide association study was to identify susceptibility genes contributing high in the French population.High myopic cases were genotyped using Affymetrix SNP 6.0 chips population controls selected from GABRIEL dataset, which samples Illumina Human610 quad array. conducted 152,234 single...