A5039603242- COVID-19 Impact on Reproduction
- Child and Adolescent Health
- Health disparities and outcomes
- Global Maternal and Child Health
- Maternal and Perinatal Health Interventions
- Birth, Development, and Health
- Maternal and fetal healthcare
- Pregnancy and preeclampsia studies
- Vaccine Coverage and Hesitancy
- Pregnancy and Medication Impact
- COVID-19 and healthcare impacts
- Infant Development and Preterm Care
- Neonatal Respiratory Health Research
- Breastfeeding Practices and Influences
- Adolescent and Pediatric Healthcare
- COVID-19 Clinical Research Studies
- Chronic Disease Management Strategies
- Global Health Care Issues
- SARS-CoV-2 and COVID-19 Research
- Maternal Mental Health During Pregnancy and Postpartum
- Emergency and Acute Care Studies
- Employment and Welfare Studies
- COVID-19 and Mental Health
- Social Issues and Policies
- Migration, Health and Trauma
University of Edinburgh
2015-2025
Public Health Scotland
2019-2025
Brigham and Women's Hospital
2022-2024
Institute of Occupational Medicine
2023
Government of the United Kingdom
2022-2023
Royal Manchester Children's Hospital
2022-2023
University of Dundee
1974-2023
Southern Health NHS Foundation Trust
2018-2022
Epidemic Intelligence Service
2022
University of South Wales
2022
Abstract Objective To assess the risk of hospital admission for coronavirus disease 2019 (covid-19) among patient facing and non-patient healthcare workers their household members. Design Nationwide linkage cohort study. Setting Scotland, UK, 1 March to 6 June 2020. Participants Healthcare aged 18-65 years, households, other members general population. Main outcome measure Admission with covid-19. Results The comprised 158 445 workers, most them (90 733; 57.3%) being facing, 229 905 Of all...
Abstract Population-level data on COVID-19 vaccine uptake in pregnancy and SARS-CoV-2 infection outcomes are lacking. We describe pregnant women Scotland, using whole-population from a national, prospective cohort. Between the start of program 8 December 2020 31 October 2021, 25,917 vaccinations were given to 18,457 women. Vaccine coverage was substantially lower than general female population 18−44 years; 32.3% giving birth 2021 had two doses compared 77.4% all The extended perinatal...
Abstract Reports of ChAdOx1 vaccine–associated thrombocytopenia and vascular adverse events have led to some countries restricting its use. Using a national prospective cohort, we estimated associations between exposure first-dose or BNT162b2 vaccination hematological using nested incident-matched case-control study confirmatory self-controlled case series (SCCS) analysis. An association was found idiopathic thrombocytopenic purpura (ITP) (0–27 d after vaccination; adjusted rate ratio (aRR)...
What is the impact of cancer in females aged ≤39 years on subsequent chance pregnancy? Cancer survivors achieved fewer pregnancies across all types, and achieving a first pregnancy was also lower. The diagnosis treatment young may be associated with reduced fertility but true deficit population unknown. We performed retrospective cohort study relating incident diagnosed between 1981 2012 to female patients Scotland 39 or less at (n = 23 201). Pregnancies were included up end 2014. Females...
We aimed to examine time trends in national perinatal outcomes pregnancies complicated by pre-existing type 1 or 2 diabetes. analysed episode-level data on all obstetric inpatient delivery events (live stillbirth) between April 1998 and 31 March 2013 (n = 813,921) using the Scottish Morbidity Record (SMR02). Pregnancies mothers with 3229) 1452) diabetes were identified from database (Scottish Care Information-Diabetes), compared among women diabetes, those without The number of increased...
Background: The BNT162b2 mRNA (Pfizer-BioNTech) and ChAdOx1 (Oxford-AstraZeneca) COVID-19 vaccines have demonstrated high efficacy against infection in phase 3 clinical trials are now being used national vaccination programmes the UK several other countries. There is an urgent need to study 'real-world' effects of these vaccines. aim our was estimate effectiveness first dose preventing hospital admissions.Methods: We conducted a prospective cohort using Early Pandemic Evaluation Enhanced...
Paediatric Multisystem Inflammatory Syndrome temporally associated with SARS-CoV-2 (PIMS-TS), first identified in April 2020, shares features of both Kawasaki disease (KD) and toxic shock syndrome (TSS). The surveillance describes the epidemiology clinical characteristics PIMS-TS United Kingdom Ireland. Public Health England initiated prospective national through British Surveillance Unit. Paediatricians were contacted monthly to report PIMS-TS, KD TSS cases electronically complete a...
The COVID-19 pandemic is responsible for increasing deaths globally. Most estimates have focused on numbers of deaths, with little direct quantification years life lost (YLL) through COVID-19. As most people dying are older underlying long-term conditions (LTCs), some speculated that YLL low. We aim to estimate attributable COVID-19, before and after adjustment number/type LTCs.
To evaluate the risk of childhood hospitalization associated with infant feeding patterns at 6-8 weeks age in Scotland.A retrospective population level study based on linkage birth, death, maternity, health, child health surveillance, and admission records for children born as single births Scotland between 1997 2009 (n = 502 948) followed up to March 2012. Descriptive analyses, Kaplan Meier tests, Cox regression were used quantify association mode respiratory, gastrointestinal, urinary...
Following the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and subsequent global spread 2019 novel disease (COVID-19), health systems populations who use them have faced unprecedented challenges. We aimed to measure impact COVID-19 on uptake hospital-based care at a national level.The study period (weeks ending 5 January 28 June 2020) encompassed pandemic announcement by World Health Organization initiation UK lockdown. undertook an interrupted time-series...
<ns3:p><ns3:bold>Background:</ns3:bold> COVID-19 is responsible for increasing deaths globally. As most people dying with are older underlying long-term conditions (LTCs), some speculate that YLL low. We aim to estimate attributable COVID-19, before and after adjustment number/type of LTCs, using the limited data available early in pandemic.</ns3:p><ns3:p> <ns3:bold>Methods:</ns3:bold> first estimated from WHO life tables, based on published age/sex Italy. then used aggregate LTCs a Bayesian...
Abstract Background The effect of vaccination for COVID-19 on onward transmission is unknown. Methods A national record linkage study determined documented cases and hospitalisations in unvaccinated household members vaccinated healthcare workers from 8 th December 2020 to 3 rd March 2021. primary endpoint was 14 days following the first dose. Results cohort comprised 194,362 (mean age 31·1 ± 20·9 years) 144,525 44·4 11·4 years). 113,253 (78·3%) received at least one dose BNT162b2 mRNA or...
The objectives of this study were to identify risk factors for severe coronavirus disease 2019 (COVID-19) and lay the basis stratification based on demographic data health records.The design was a matched case-control study. Severe COVID-19 defined as either positive nucleic acid test acute respiratory syndrome 2 (SARS-CoV-2) in national database followed by entry critical care unit or death within 28 days certificate with underlying cause. Up 10 controls per case sex, age, primary practice...
To inform the on-going debate about use of universal prescriptive versus national intrauterine growth charts, we compared perinatal mortality for small and large-for-gestational-age (SGA/LGA) infants according to international charts in Europe.We classified singleton births from 33 42 weeks gestation 2010 2014 15 countries (N = 1,475,457) as SGA (birthweight <10th percentile) LGA (>90th using Intergrowth-21st newborn standards based on customised methodology. We computed sex-adjusted odds...
Abstract Evidence on associations between COVID-19 vaccination or SARS-CoV-2 infection and the risk of congenital anomalies is limited. Here we report a national, population-based, matched cohort study using linked electronic health records from Scotland (May 2020-April 2022) to estimate association and, separately, six weeks pre-conception 19 days gestation [1] any major anomaly [2] non-genetic anomaly. Mothers vaccinated in this pregnancy exposure period mostly received an mRNA vaccine...
Self‐poisoning by ingestion or inhalation is common, and it important to study its various epidemiological manifestations with clear definitions. Data on fatal self‐poisonings are recorded nationally within the UK codified according International Classification of Diseases (ICD) revision relevant at time. Most as suicides, accidental deaths undetermined (‘open verdicts’). Non‐fatal self‐poisoning data, whether a manifestation deliberate self‐harm, through hospital discharge information but...
To determine the degree to which changing patterns of deprivation in Scotland and rest Great Britain between 1981 2001 explain Scotland's higher mortality rates over that period.Cross-sectional analyses using population data from around 1981, 1991 censuses.Great (GB).Populations enumerated censuses.Carstairs scores derived for wards (England Wales) postcode sectors (Scotland). Mortality adjusted age, sex decile.Between became less deprived relative Britain. Age standardized all-cause...
Stillbirth risk is increased in pregnancy complicated by diabetes. Fear of stillbirth has major influence on obstetric management, particularly timing delivery. We analysed population-level data from Scotland to describe stillbirths women with diabetes and associated factors.A retrospective cohort singleton deliveries mothers type 1 (n = 3778) 2 1614) April 1998 30 June 2016 was using linked routine care datasets. Maternal fetal characteristics, HbA1c delivery were compared between stillborn...
Abstract Background The objective of this study was to investigate the relation severe COVID-19 prior drug prescribing. Methods Severe cases were defined by entry critical care or fatal outcome. For matched case-control (REACT-SCOT), all 4251 in Scotland since start epidemic for age, sex and primary practice 36,738 controls from population register. Records linked hospital discharges June 2015 dispensed prescriptions issued during last 240 days. Results strongly associated with number...