A5067793495- Reproductive Biology and Fertility
- Ovarian function and disorders
- Constraint Satisfaction and Optimization
- Ovarian cancer diagnosis and treatment
- Cancer Risks and Factors
- Sperm and Testicular Function
- Logic, programming, and type systems
- Hypothalamic control of reproductive hormones
- Reproductive Health and Technologies
- Assisted Reproductive Technology and Twin Pregnancy
- Childhood Cancer Survivors' Quality of Life
- Data Management and Algorithms
- Reproductive System and Pregnancy
- Clinical practice guidelines implementation
- Advanced Database Systems and Queries
- AI-based Problem Solving and Planning
- Artificial Intelligence in Healthcare and Education
- Topic Modeling
- Birth, Development, and Health
- Formal Methods in Verification
- Machine Learning in Healthcare
- Gynecological conditions and treatments
- Patient-Provider Communication in Healthcare
- Distributed and Parallel Computing Systems
- Natural Language Processing Techniques
University of St Andrews
2016-2025
St Andrew's Healthcare
2024
University of Copenhagen
2017
Copenhagen University Hospital
2017
Aarhus University Hospital
2017
The measurement of circulating anti-Müllerian hormone (AMH) has been applied to a wide array clinical applications, mainly based on its ability reflect the number antral and pre-antral follicles present in ovaries. AMH suggested predict ovarian response hyperstimulation ovaries for IVF timing menopause, indicate iatrogenic damage follicle reserve. It also proposed as surrogate count (AFC) diagnosis polycystic ovary syndrome (PCOS). This paper is summary presentations at European Society...
The human ovary contains a fixed number of non-growing follicles (NGFs) established before birth that decline with increasing age culminating in the menopause at 50–51 years. objective this study is to model age-related population NGFs from conception menopause. Data were taken eight separate quantitative histological studies (n = 325) which NGF populations known ages seven weeks post 51 years (median 32 years) calculated. data set was fitted 20 peak function models, results ranked by...
We determined the best model available for natural follicle decline in healthy women and used this to calculate radiosensitivity of human oocyte.Ovarian failure was diagnosed six patients with a median age 13.2 years (range 12.5-16.0) who were treated total body irradiation (14.4 Gy) at 11.5 (4.9-15.1). previously estimated dose radiation required destroy 50% oocytes (LD(50)) be <4 Gy. This estimate is an oversimplification, because decay represents instantaneous rate temporal change based...
Background Anti-Müllerian hormone (AMH) is a product of growing ovarian follicles. The concentration AMH in blood may also reflect the non-growing follicle (NGF) population, i.e. reserve, and be value predicting reproductive lifespan. A full description production up to menopause has not been previously reported. Methodology/Principal Findings By searching published literature for concentrations healthy pre-menopausal females, using our own data (combined ) we have generated robustly...
Anti-Müllerian hormone (AMH) is exclusively produced by granulosa cells (GC) of the developing pre-antral and antral follicles, AMH increasingly used to assess ovarian function. It unclear which size follicles make most (total content) are main contributors circulating concentrations. To determine gene expression in GC (q-RT–PCR) follicular production (Elisa RIA) relation development, 87 (3–13 mm diameter) including both corresponding fluid (FF) were collected connection with fertility...
Ovarian tissue cryopreservation with later reimplantation has been shown to preserve fertility in adult women, but this approach remains unproven and experimental children adolescents. We aimed assess the use of Edinburgh selection criteria for ovarian girls young women cancer determine whether we are offering invasive procedure patients who most at risk premature insufficiency.Cryopreservation selectively offered met since 1996. Between Jan 1, 1996, June 30, 2012, 410 female younger than 18...
What is the impact of cancer in females aged ≤39 years on subsequent chance pregnancy? Cancer survivors achieved fewer pregnancies across all types, and achieving a first pregnancy was also lower. The diagnosis treatment young may be associated with reduced fertility but true deficit population unknown. We performed retrospective cohort study relating incident diagnosed between 1981 2012 to female patients Scotland 39 or less at (n = 23 201). Pregnancies were included up end 2014. Females...
Abstract Infertility affects 1-in-6 couples, with repeated intensive cycles of assisted reproductive technology (ART) required by many to achieve a desired live birth. In ART, typically, clinicians and laboratory staff consider patient characteristics, previous treatment responses, ongoing monitoring determine decisions. However, the reproducibility, weighting, interpretation these characteristics are contentious, highly operator-dependent, resulting in considerable reliance on clinical...
Abstract Current understanding is that the human ovary contains a fixed number of several million non-growing follicles (NGF), established by five months gestational age, declines with increasing age to menopause when approximately 1,000 NGF remain at an average 50-51 years. With 450 ovulatory monthly cycles in normal reproductive lifespan, this progressive decline numbers attributed follicle death apoptosis. Individual histological studies have quantified over limited ranges. However, no...
The diagnosis of hypogonadism in human males includes identification low serum testosterone levels, and hence there is an underlying assumption that normal ranges for the healthy population are known all ages. However, to our knowledge, no such reference model exists literature, availability applicable biochemical range would be helpful clinical assessment hypogonadal men. In this study, using selection validation analysis data identified extracted from thirteen studies, we derive validate a...
Improving survival for women with early breast cancer (eBC) requires greater attention to the consequences of treatment, including risk ovarian function. We have assessed whether biochemical markers reserve might improve prediction chemotherapy related amenorrhoea.Women (n=59, mean age 42.6 years [(range 23.3-52.5]) eBC were recruited before any treatment. Pretreatment (anti-Müllerian hormone [AMH], follicle-stimulating [FSH], inhibin B) analysed in relation status at 2 years.Pretreatment...
How does in vitro culture alter the human ovarian cortical extracellular matrix (ECM) network structure? The ECM composition and architecture vary different layers of cortex are remodelled during culture. is scaffold within which follicles stromal cells organized. Its structural properties constantly evolve to accommodate follicle development expansion. Tissue preparation for primordial native involves mechanical loosening; this induces undefined modifications alters cell–cell contact,...
Large language models (LLMs), such as ChatGPT (Open AI), are increasingly used in medicine and supplement standard search engines information sources. This leads to more "consultations" of LLMs about personal medical symptoms.This study aims evaluate ChatGPT's performance answering clinical case-based questions otorhinolaryngology (ORL) comparison ORL consultants' answers.We 41 from established books past German state examinations for doctors. The were answered by both consultants 3. rated...
Abstract Infertility affects one-in-six couples, often necessitating in vitro fertilization treatment (IVF). IVF generates complex data, which can challenge the utilization of full richness data during decision-making, leading to reliance on simple ‘rules-of-thumb’. Machine learning techniques are well-suited analyzing provide data-driven recommendations improve decision-making. In this multi-center study ( n = 19,082 treatment-naive female patients), including 11 European centers, we...
The human ovary contains a fixed number of primordial follicles that decreases bi-exponentially with age, culminating in the menopause at an average age 50-51 years. There currently is no reliable test ovarian reserve for individual women will accurately predict their remaining reproductive lifespan.We use Faddy-Gosden model follicle population decline to describe natural decay pool. Assuming wide distribution due variation birth, we early and late menopausal women. Using published data on...
The measurement of ovarian volume has been shown to be a useful indirect indicator the reserve in women reproductive age, diagnosis and management number disorders puberty adult function, is under investigation as screening tool for cancer. To date there no normative model throughout life. By searching published literature healthy females, using our own data from multiple sources (combined n=59,994) we have generated robustly validated first conception 82 years age. This shows that 69%...
Do women with BRCA1 or BRCA2 mutations have reduced ovarian reserve, as measured by circulating anti-Müllerian hormone (AMH) concentration? Women a germline mutation in reserve AMH. The DNA repair enzymes encoded and are implicated reproductive aging. Circulating AMH is biomarker of hence lifespan. This was cross-sectional study concentrations 693 at the time enrolment into Kathleen Cuningham Foundation Consortium for research Familial Breast Cancer (kConFab) cohort (recruitment from 19...