Roger L. Milne

ORCID: 0000-0001-5764-7268
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • BRCA gene mutations in cancer
  • Adipokines, Inflammation, and Metabolic Diseases
  • Genetic Associations and Epidemiology
  • Cancer Risks and Factors
  • Epigenetics and DNA Methylation
  • Nutrition, Genetics, and Disease
  • Nutritional Studies and Diet
  • Global Cancer Incidence and Screening
  • Genetic factors in colorectal cancer
  • Vitamin D Research Studies
  • Cancer Genomics and Diagnostics
  • Colorectal Cancer Screening and Detection
  • Cancer survivorship and care
  • Ovarian cancer diagnosis and treatment
  • Estrogen and related hormone effects
  • Breast Cancer Treatment Studies
  • Pancreatic and Hepatic Oncology Research
  • Genomic variations and chromosomal abnormalities
  • RNA modifications and cancer
  • Cancer, Stress, Anesthesia, and Immune Response
  • Birth, Development, and Health
  • Bioinformatics and Genomic Networks
  • Genomics and Chromatin Dynamics
  • DNA Repair Mechanisms
  • Gene expression and cancer classification

The University of Melbourne
2016-2025

Monash University
2018-2025

Cancer Council Victoria
2016-2025

Monash Health
2018-2025

QIMR Berghofer Medical Research Institute
2010-2024

Spanish National Cancer Research Centre
2008-2023

Imperial College London
2021-2023

Centre International de Recherche sur le Cancer
2022-2023

University of Kansas Medical Center
2023

Murdoch Children's Research Institute
2023

Douglas F. Easton Karen A. Pooley Alison M. Dunning Paul D.P. Pharoah Deborah J. Thompson and 95 more Dennis G. Ballinger Jeffery P. Struewing Jonathan J. Morrison Helen I. Field Robert Luben Nicholas J. Wareham Shahana Ahmed Catherine S. Healey Richard Bowman Craig Luccarini Don Conroy Mitul Shah Hannah Munday Clare Jordan Barbara Perkins Judy West Karen Redman Kristy Driver Kerstin B. Meyer Christopher A. Haiman Laurence Kolonel Brian E. Henderson Loı̈c Le Marchand Paul Brennan Suleeporn Sangrajrang Valérie Gaborieau Fabrice Odefrey Chen‐Yang Shen Pei‐Ei Wu Hui‐Chun Wang Diana Eccles D. Gareth Evans Julian Peto Olivia Fletcher Nichola Johnson Sheila Seal Michael R. Stratton Nazneen Rahman Georgia Chenevix‐Trench Stig E. Bojesen Børge G. Nordestgaard C. K. Axelsson Montserrat García‐Closas Louise A. Brinton Stephen J. Chanock Jolanta Lissowska Beata Pepłońska Heli Nevanlinna Rainer Fagerholm Hannaleena Eerola Daehee Kang Keun-Young Yoo Dong‐Young Noh Sei Hyun Ahn David J. Hunter Susan E. Hankinson David G. Cox Per Hall Sara Wedrén Jianjun Liu Yen-Ling Low Natalia Bogdanova Peter Schürmann Thilo Dörk Rob A.�E.�M. Tollenaar Catharina E. Jacobi Peter Devilee Jan G.M. Klijn Alice J. Sigurdson Michele M. Doody Bruce H. Alexander Jinghui Zhang Angela Cox Ian W. Brock Gordon R. Macpherson Malcolm Reed Fergus J. Couch Ellen L. Goode Janet E. Olson Hanne Meijers‐Heijboer Ans van den Ouweland André G. Uitterlinden Fernando Rivadeneira Roger L. Milne Glòria Ribas Anna González‐Neira Javier Benı́tez John L. Hopper Margaret McCredie Melissa C. Southey Graham G. Giles Chris Schroen Christina Justenhoven Hiltrud Brauch Ute Hamann

10.1038/nature05887 article EN Nature 2007-05-27

<h3>Importance</h3> The clinical management of<i>BRCA1</i>and<i>BRCA2</i>mutation carriers requires accurate, prospective cancer risk estimates. <h3>Objectives</h3> To estimate age-specific risks of breast, ovarian, and contralateral breast for mutation to evaluate modification by family history location. <h3>Design, Setting, Participants</h3> Prospective cohort study 6036<i>BRCA1</i>and 3820<i>BRCA2</i>female (5046 unaffected 4810 with or ovarian both at baseline) recruited in 1997-2011...

10.1001/jama.2017.7112 article EN JAMA 2017-06-20

Data for front-line health-care workers and risk of COVID-19 are limited. We sought to assess among compared with the general community effect personal protective equipment (PPE) on risk.

10.1016/s2468-2667(20)30164-x article EN cc-by-nc-nd The Lancet Public Health 2020-07-31
Kyriaki Michailidou Per Hall Anna González‐Neira Maya Ghoussaini Joe Dennis and 95 more Roger L. Milne Marjanka K. Schmidt Jenny Chang‐Claude Stig E. Bojesen Manjeet K. Bolla Qin Wang Ed Dicks Andrew Lee Clare Turnbull Nazneen Rahman Olivia Fletcher Julian Peto Lorna J. Gibson Isabel dos‐Santos‐Silva Heli Nevanlinna Taru Muranen Kristiina Aittomäki Carl Blomqvist Kamila Czene Astrid Irwanto Jianjun Liu Quinten Waisfisz Hanne Meijers‐Heijboer Muriel A. Adank Rob B. van der Luijt Rebecca Hein Norbert Dahmen L. Beckman Alfons Meindl Rita K. Schmutzler Bertram Müller‐Myhsok Peter Lichtner John L. Hopper Melissa C. Southey Enes Makalic Daniel F. Schmidt André G. Uitterlinden Albert Hofman David J. Hunter Stephen J. Chanock Daniel Vincent François Bacot Daniel C. Tessier Sander Canisius Lodewyk F.A. Wessels Christopher A. Haiman Mitul Shah Robert Luben Judith Brown Craig Luccarini Nils Schoof Keith Humphreys Jingmei Li Børge G. Nordestgaard Sune F. Nielsen Henrik Flyger Fergus J. Couch Xianshu Wang Celine M. Vachon Kristen N. Stevens Diether Lambrechts Matthieu Moisse Robert Paridaens Marie‐Rose Christiaens Anja Rudolph Stefan Nickels Dieter Flesch‐Janys Nichola Johnson Zoe Aitken Kirsimari Aaltonen Tuomas Heikkinen Annegien Broeks Laura J. van’t Veer C. Ellen van der Schoot Pascal Guénel Thérèse Truong Pierre Laurent–Puig F. Ménégaux Frederik Marmé Andreas Schneeweiß Christof Sohn Barbara Burwinkel M. Pilar Zamora José Ignacio Arias Pérez Guillermo Pita M. Rosario Alonso Angela Cox Ian W. Brock Simon S. Cross Malcolm Reed Elinor J. Sawyer Ian Tomlinson Michael J. Kerin Nicola Miller Brian E. Henderson

10.1038/ng.2563 article EN Nature Genetics 2013-03-27
Ganna Chornokur Hui‐Yi Lin Jonathan P. Tyrer Kate Lawrenson Joe Dennis and 95 more Ernest K. Amankwah Xiaotao Qu Ya-Yu Tsai Heather Jim Zhihua Chen Y. Ann Chen Jennifer Permuth‐Wey Katja K.H. Aben Hoda Anton‐Culver Natalia Antonenkova Fiona Bruinsma Elisa V. Bandera Yukie T. Bean Matthias W. Beckmann Maria Bisogna Line Bjørge Natalia Bogdanova Louise A. Brinton Angela Brooks‐Wilson Clareann H. Bunker Ralf Bützow Ian Campbell Karen Carty Jenny Chang‐Claude Linda S. Cook Daniel W. Cramer Julie M. Cunningham Cezary Cybulski Agnieszka Dansonka‐Mieszkowska Andreas du Bois Evelyn Despierre Ed Dicks Jennifer A. Doherty Thilo Dörk Matthias Dürst Douglas F. Easton Diana Eccles Robert P. Edwards Arif B. Ekici Peter A. Fasching Brooke L. Fridley Yu‐Tang Gao Aleksandra Gentry‐Maharaj Graham G. Giles Rosalind Glasspool Marc T. Goodman Jacek Gronwald Patricia Harrington Philipp Harter Alexander Hein Florian Heitz Michelle A.T. Hildebrandt Peter Hillemanns Claus Høgdall Estrid Høgdall Satoyo Hosono Anna Jakubowska Allan Jensen Bu‐Tian Ji Beth Y. Karlan Linda E. Kelemen Mellissa Kellar Lambertus A. Kiemeney Camilla Krakstad Susanne K. Kjær Jolanta Kupryjańczyk Diether Lambrechts Sandrina Lambrechts Nhu D. Le Alice W. Lee Shashi Lele Arto Leminen Jenny Lester Douglas A. Levine Dong Liang Boon Kiong Lim Jolanta Lissowska Karen H. Lu Jan Lubiński Lene Lundvall Leon F.A.G. Massuger Keitaro Matsuo Valerie McGuire Esther M. John Iain A. McNeish Usha Menon Roger L. Milne Francesmary Modugno Kirsten B. Moysich Roberta B. Ness Heli Nevanlinna Ursula Eilber Kunle Odunsi Sara H. Olson Irene Orlow

Background Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which turn may promote formation reactive oxygen species, promoting DNA damage expression key regulatory cancer genes. As uncontrolled proliferation are hallmarks cancer, including epithelial ovarian (EOC), we hypothesized that inherited variation genes contributes EOC risk. Methods In total, samples were obtained from 14,525 case subjects...

10.1371/journal.pone.0128106 article EN cc-by PLoS ONE 2015-06-19
Xiaohong R. Yang Jenny Chang‐Claude Ellen L. Goode Fergus J. Couch Heli Nevanlinna and 95 more Roger L. Milne Mia M. Gaudet Marjanka K. Schmidt Annegien Broeks Angela Cox Peter A. Fasching Rebecca Hein Amanda B. Spurdle Fiona M. Blows Kristy Driver Dieter Flesch‐Janys Judith Heinz Hans‐Peter Sinn Alina Vrieling Tuomas Heikkinen Kristiina Aittomäki Päivi Heikkilä Carl Blomqvist Jolanta Lissowska Beata Pepłońska Stephen J. Chanock Jonine D. Figueroa Louise A. Brinton Per Hall Kamila Czene Keith Humphreys Hatef Darabi Jianjun Liu Laura van ‘t Veer Flora E. van Leeuwen Irene L. Andrulis Gord Glendon Julia A. Knight Anna Marie Mulligan Frances P. O’Malley Nayana Weerasooriya Esther M. John Matthias W. Beckmann Arndt Hartmann Sebastian Weihbrecht David L. Wachter Sebastian M. Jud Christian R. Loehberg Laura Baglietto Dallas R. English Graham G. Giles Catriona McLean Gianluca Severi Diether Lambrechts T. Vandorpe Caroline Weltens Robert Paridaens Ann Smeets Patrick Neven Hans Wildiers Xianshu Wang Janet E. Olson Victoria Cafourek Zachary Fredericksen Matthew Kosel Celine M. Vachon Helen Cramp Daniel Connley Simon S. Cross Sabapathy P. Balasubramanian Malcolm Reed Thilo Dörk Michael Bremer Andreas Meyer Johann H. Karstens Aysun Ay Tjoung‐Won Park‐Simon Peter Hillemanns José Ignacio Arias Pérez Primitiva Menéndez Rodríguez Pilar Zamora Javier Benı́tez Yon‐Dschun Ko Hans‐Peter Fischer Ute Hamann Beate Pesch Thomas Brüning Christina Justenhoven Hiltrud Brauch Diana Eccles William Tapper Sue Gerty Elinor J. Sawyer Ian Tomlinson Angela Jones Michael J. Kerin Nicola Miller Niall McInerney Hoda Anton‐Culver Argyrios Ziogas

Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone (PR) expression status of the tumors.

10.1093/jnci/djq526 article EN JNCI Journal of the National Cancer Institute 2010-12-29
Liisa M. Pelttari Sofia Khan Mikko Vuorela Johanna I. Kiiski Sara Vilske and 92 more Viivi Nevanlinna Salla Ranta Johanna Schleutker Robert Winqvist Anne Kallioniemi Thilo Dörk Natalia Bogdanova Jonine D. Figueroa Paul D.P. Pharoah Marjanka K. Schmidt Alison M. Dunning Montserrat García‐Closas Manjeet K. Bolla Joe Dennis Kyriaki Michailidou Sophia Wang John L. Hopper Melissa C. Southey Efraim H. Rosenberg Peter A. Fasching Matthias W. Beckmann Julian Peto Isabel dos‐Santos‐Silva Elinor J. Sawyer Ian Tomlinson Barbara Burwinkel Harald Surowy Pascal Guénel Thérèse Truong Stig E. Bojesen Børge G. Nordestgaard Javier Benı́tez Anna González‐Neira Susan L. Neuhausen Hoda Anton‐Culver Hermann Brenner Volker Arndt Alfons Meindl Rita K. Schmutzler Hiltrud Brauch Thomas Brüning Annika Lindblom Sara Margolin Graham J. Mann Jaana M. Hartikainen Georgia Chenevix‐Trench Laurien Van Dyck Hilde Janssen Jenny Chang-Claude Anja Rudolph Paolo Radice Paolo Peterlongo Emily Hallberg Janet E. Olson Graham G. Giles Roger L. Milne Christopher A. Haiman Fredrick R. Schumacher Jacques Simard Martine Dumont Vessela Kristensen Anne‐Lise Børresen‐Dale Wei Zheng Alicia Beeghly‐Fadiel Mervi Grip Irene L. Andrulis Gord Glendon Peter Devilee Caroline Seynaeve Maartje J. Hooning Margriet Collée Angela Cox Simon S. Cross Mitul Shah Robert Luben Ute Hamann Diana Torres Anna Jakubowska Jan Lubiński Fergus J. Couch Drakoulis Yannoukakos Nick Orr Anthony J. Swerdlow Hatef Darabi Jingmei Li Kamila Czene Per Hall Douglas F. Easton Johanna Mattson Carl Blomqvist Kristiina Aittomäki Heli Nevanlinna

Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 the risk of female cancer rs1314913 male cancer. The aim this study was investigate role RAD51B variants in predisposition, particularly context familial Finland. We sequenced coding region 168 Finnish patients from Helsinki for identification possible recurrent founder mutations. In addition, we studied known rs999737, rs2588809, SNPs haplotypes 44,791 cases 43,583 controls 40...

10.1371/journal.pone.0153788 article EN public-domain PLoS ONE 2016-05-05
Sofia Khan Dario Greco Kyriaki Michailidou Roger L. Milne Taru Muranen and 95 more Tuomas Heikkinen Kirsimari Aaltonen Joe Dennis Manjeet K. Bolla Jianjun Liu Per Hall Astrid Irwanto Keith Humphreys Jingmei Li Kamila Czene Jenny Chang‐Claude Rebecca Hein Anja Rudolph Petra Seibold Dieter Flesch‐Janys Olivia Fletcher Julian Peto Isabel dos‐Santos‐Silva Nichola Johnson Lorna J. Gibson Zoe Aitken John L. Hopper Helen Tsimiklis Minh Bui Enes Makalic Daniel F. Schmidt Melissa C. Southey Carmel Apicella Jennifer Stone Quinten Waisfisz Hanne Meijers‐Heijboer Muriel A. Adank Rob B. van der Luijt Alfons Meindl Rita K. Schmutzler Bertram Müller‐Myhsok Peter Lichtner Clare Turnbull Nazneen Rahman Stephen J. Chanock David J. Hunter Angela Cox Simon S. Cross Malcolm Reed Marjanka K. Schmidt Annegien Broeks Laura J. V. a. n't. Veer Frans B.L. Hogervorst Peter A. Fasching Michael Schrauder Arif B. Ekici Matthias W. Beckmann Stig E. Bojesen Børge G. Nordestgaard Sune F. Nielsen Henrik Flyger Javier Benı́tez Pilar Zamora José Ignacio Arias Pérez Christopher A. Haiman Brian E. Henderson Fredrick R. Schumacher Loı̈c Le Marchand Paul D.P. Pharoah Alison M. Dunning Mitul Shah Robert Luben Judith Brown Fergus J. Couch Xianshu Wang Celine M. Vachon Janet E. Olson Diether Lambrechts Matthieu Moisse Robert Paridaens Marie-Rose Christiaens Pascal Guénel Thérèse Truong Pierre Laurent–Puig Claire Mulot F. Marmé Barbara Burwinkel Andreas Schneeweiß Christof Sohn Elinor J. Sawyer Ian Tomlinson Michael J. Kerin Nicola Miller Irene L. Andrulis Julia A. Knight Sandrine Tchatchou Anna Marie Mulligan Thilo Dörk Natalia Bogdanova Natalia Antonenkova

Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or the miRNA binding sites may affect dependent gene expression regulation, which has been implicated various cancers, including breast cancer, and alter individual susceptibility to cancer. We investigated associations between related SNPs cancer risk. First we evaluated 2,196 a case-control study combining nine genome wide association studies (GWAS). Second, further 42 with suggestive evidence for using...

10.1371/journal.pone.0109973 article EN cc-by PLoS ONE 2014-11-12

10.1038/ng1981 article EN Nature Genetics 2007-02-11
Stig E. Bojesen Karen A. Pooley Sharon E. Johnatty Jonathan Beesley Kyriaki Michailidou and 95 more Jonathan P. Tyrer Stacey L. Edwards Hilda A. Pickett Howard C. Shen Chanel E. Smart Kristine M. Hillman L. Phuong Kate Lawrenson Michael D. Stutz Yi Lu Rod Karevan Nicholas T. Woods Rebecca L. Johnston Juliet D. French Xiaohong Chen Maren Weischer Sune F. Nielsen Melanie Maranian Maya Ghoussaini Shahana Ahmed Caroline Baynes Manjeet K. Bolla Qin Wang Joe Dennis Lesley McGuffog Daniel Barrowdale Andrew Lee Sue Healey Michael Lush Daniel C. Tessier Daniel Vincent Françis Bacot Ignace Vergote Sandrina Lambrechts Evelyn Despierre Harvey A. Risch Anna González‐Neira Mary Anne Rossing Guillermo Pita Jennifer A. Doherty Núria Álvarez Melissa C. Larson Brooke L. Fridley Nils Schoof Jenny Chang‐Claude Mine Cicek Julian Peto Kimberly R. Kalli Annegien Broeks Sebastian M. Armasu Marjanka K. Schmidt Linde M. Braaf Boris Winterhoff Heli Nevanlinna Gottfried E. Konecny Diether Lambrechts Lisa Rogmann Pascal Guénel Attila Teoman Roger L. Milne Joaquín J. García Angela Cox Vijayalakshmi Shridhar Barbara Burwinkel Frederik Marmé Rebecca Hein Elinor J. Sawyer Christopher A. Haiman Shan Wang‐Gohrke Irene L. Andrulis Kirsten B. Moysich John L. Hopper Kunle Odunsi Annika Lindblom Graham G. Giles Hermann Brenner Jacques Simard Galina Lurie Peter A. Fasching Michael E. Carney Paolo Radice Lynne R. Wilkens Anthony J. Swerdlow Marc T. Goodman Hiltrud Brauch Montserrat García‐Closas Peter Hillemanns Robert Winqvist Matthias Dürst Peter Devilee Ingo B. Runnebaum Anna Jakubowska Jan Lubiński Graham J. Mann Ralf Bützow

10.1038/ng.2566 article EN Nature Genetics 2013-03-27
Shahana Ahmed Gilles Thomas Maya Ghoussaini Catherine S. Healey Manjeet K. Humphreys and 95 more Radka Platte Jonathan J. Morrison Melanie Maranian Karen A. Pooley Robert Luben Diana Eccles D. Gareth Evans Olivia Fletcher Nichola Johnson Isabel dos‐Santos‐Silva Julian Peto Michael R. Stratton Nazneen Rahman Kevin B. Jacobs Ross L. Prentice Garnet L. Anderson Aleksandar Rajkovic J. David Curb Regina G. Ziegler Christine D. Berg Saundra S. Buys Catherine A. McCarty Heather Spencer Feigelson Eugenia E. Calle Michael J. Thun W. Ryan Diver Stig E. Bojesen Børge G. Nordestgaard Henrik Flyger Thilo Dörk Peter Schürmann Peter Hillemanns Johann H. Karstens Natalia Bogdanova Natalia Antonenkova Iosif V. Zalutsky Marina Bermisheva С.А. Федорова Э. К. Хуснутдинова Daehee Kang Keun-Young Yoo Dong‐Young Noh Sei-Hyun Ahn Peter Devilee Christi J. van Asperen Robert A.E.M. Tollenaar Caroline Seynaeve Montserrat García‐Closas Jolanta Lissowska Louise A. Brinton Beata Pepłońska Heli Nevanlinna Tuomas Heikkinen Kristiina Aittomäki Carl Blomqvist John L. Hopper Melissa C. Southey Letitia Smith Amanda B. Spurdle Marjanka K. Schmidt Annegien Broeks Richard R van Hien Sten Cornelissen Roger L. Milne Glòria Ribas Anna González‐Neira Javier Benı́tez Rita K. Schmutzler Barbara Burwinkel Claus R. Bartram Alfons Meindl Hiltrud Brauch Christina Justenhoven Ute Hamann Jenny Chang‐Claude Rebecca Hein Shan Wang‐Gohrke Annika Lindblom Sara Margolin Graham J. Mann Veli-Matti Kosma Vesa Kataja Janet E. Olson Xianshu Wang Zachary Fredericksen Graham G. Giles Gianluca Severi Laura Baglietto Dallas R. English Susan E. Hankinson David G. Cox Peter Kraft Lars J. Vatten Kristian Hveem Merethe Kumle

10.1038/ng.354 article EN Nature Genetics 2009-03-29

Abstract Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank GWA consortia, we found that a one standard deviation increment average acceleration was (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) (OR: 0.66, CI: 0.48 0.90, 0.01)....

10.1038/s41467-020-14389-8 article EN cc-by Nature Communications 2020-01-30
Montserrat García‐Closas Fergus J. Couch Sara Lindström Kyriaki Michailidou Marjanka K. Schmidt and 95 more Mark N. Brook Nick Orr Suhn K. Rhie Elio Ríboli Heather Spencer Feigelson Loı̈c Le Marchand Julie E. Buring Diana Eccles Penelope Miron Peter A. Fasching Hiltrud Brauch Jenny Chang‐Claude Jane Carpenter Andrew K. Godwin Heli Nevanlinna Graham G. Giles Angela Cox John L. Hopper Manjeet K. Bolla Qin Wang Joe Dennis Ed Dicks Will J Howat Nils Schoof Stig E. Bojesen Diether Lambrechts Annegien Broeks Irene L. Andrulis Pascal Guénel Barbara Burwinkel Elinor J. Sawyer Antoinette Hollestelle Olivia Fletcher Robert Winqvist Hermann Brenner Graham J. Mann Ute Hamann Alfons Meindl Annika Lindblom Wei Zheng Peter Devillee Mark S. Goldberg Jan Lubiński Vessela N. Kristensen Anthony J. Swerdlow Hoda Anton‐Culver Thilo Dörk Kenneth Muir Keitaro Matsuo Anna H. Wu Paolo Radice Soo‐Hwang Teo Xiao‐Ou Shu William J. Blot Daehee Kang Mikael Hartman Suleeporn Sangrajrang Chen‐Yang Shen Melissa C. Southey Daniel J. Park Fleur Hammet Jennifer Stone Laura J. van’t Veer Emiel J. Rutgers Artitaya Lophatananon Sarah Stewart‐Brown Pornthep Siriwanarangsan Julian Peto Michael Schrauder Arif B. Ekici Matthias W. Beckmann Isabel dos‐Santos‐Silva Nichola Johnson Helen R. Warren Ian Tomlinson Michael J. Kerin Nicola Miller F Marmé Andreas Schneeweiß Christof Sohn Thérèse Truong Pierre Laurent–Puig Pierre Kerbrat Børge G. Nordestgaard Sune F. Nielsen Henrik Flyger Roger L. Milne José Ignacio Arias Pérez Primitiva Menéndez Heiko Müller Volker Arndt Christa Stegmaier Peter Lichtner Magdalena Lochmann Christina Justenhoven

10.1038/ng.2561 article EN Nature Genetics 2013-03-27

The rapid pace of the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) presents challenges to robust collection population-scale data address this global health crisis. We established COronavirus Pandemic Epidemiology (COPE) Consortium unite scientists with expertise in big research and epidemiology develop COVID Symptom Study, previously known as Tracker, mobile application. This application-which offers on risk factors, predictive...

10.1126/science.abc0473 article EN cc-by Science 2020-05-05
Montserrat García‐Closas Per Hall Heli Nevanlinna Karen A. Pooley Jonathan J. Morrison and 95 more Douglas Richesson Stig E. Bojesen Børge G. Nordestgaard C. K. Axelsson José Ignacio Arias Roger L. Milne Glòria Ribas Anna González‐Neira Javier Benı́tez Pilar Zamora Hiltrud Brauch Christina Justenhoven Ute Hamann Yon‐Dschun Ko Thomas Bruening Susanne Haas Thilo Dörk Peter Schürmann Peter Hillemanns Natalia Bogdanova Michael Bremer Johann H. Karstens Rainer Fagerholm Kirsimari Aaltonen Kristiina Aittomäki Karl von Smitten Carl Blomqvist Graham J. Mann Matti Uusitupa Matti Eskelinen Maria Tengström Veli‐Matti Kosma Vesa Kataja Georgia Chenevix‐Trench Amanda B. Spurdle Jonathan Beesley Xiaohong Chen Peter Devilee Christi J. van Asperen Catharina E. Jacobi Rob A.�E.�M. Tollenaar Petra E.A. Huijts Jan G.M. Klijn Jenny Chang‐Claude Silke Kropp Tracy Slanger Dieter Flesch‐Janys Elke Mutschelknauss Ramona Salazar Shan Wang‐Gohrke Fergus J. Couch Ellen L. Goode Janet E. Olson Celine M. Vachon Zachary S. Fredericksen Graham G. Giles Laura Baglietto Gianluca Severi John L. Hopper Dallas R. English Melissa C. Southey Christopher A. Haiman Brian E. Henderson Laurence N. Kolonel Loı̈c Le Marchand Daniel O. Stram David J. Hunter Susan E. Hankinson David G. Cox Rulla M. Tamimi Peter Kraft Mark E. Sherman Stephen J. Chanock Jolanta Lissowska Louise A. Brinton Beata Pepłońska Jan G.M. Klijn Maartje J. Hooning Han Meijers-Heijboer J. Margriet Collée Ans van den Ouweland André G. Uitterlinden Jianjun Liu Low Yen Lin Yuqing Li Keith Humphreys Kamila Czene Angela Cox Sabapathy P. Balasubramanian Simon S. Cross Malcolm Reed Fiona M. Blows Kristy Driver Alison M. Dunning Jonathan P. Tyrer

A three-stage genome-wide association study recently identified single nucleotide polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (FGFR2), trinucleotide repeat containing 9 (TNRC9), mitogen-activated protein kinase 3 K1 (MAP3K1), 8q24, and lymphocyte-specific 1 (LSP1)) associated with breast cancer risk. We investigated whether the associations between these SNPs risk varied by clinically important tumor characteristics up to 23,039 invasive cases 26,273 controls from 20...

10.1371/journal.pgen.1000054 article EN cc-by PLoS Genetics 2008-04-25
Roger L. Milne Karoline Kuchenbaecker Kyriaki Michailidou Jonathan Beesley Siddhartha Kar and 95 more Sara Lindström Shirley Hui Audrey Lemaçon Penny Soucy Joe Dennis Xia Jiang Asha Rostamianfar Hilary K. Finucane Manjeet K. Bolla Lesley McGuffog Qin Wang Cora M. Aalfs Marcia Adams Julian Adlard Simona Agata Shahana Ahmed Habibul Ahsan Kristiina Aittomäki Fares Al‐Ejeh Jamie Allen Christine B. Ambrosone Christopher I. Amos Irene L. Andrulis Hoda Anton‐Culver Natalia Antonenkova Volker Arndt Norbert Arnold Kristan J. Aronson Bernd Auber Paul L. Auer Margreet G.E.M. Ausems Jacopo Azzollini François Bacot Judith Balmañà Monica Barile Laure Barjhoux Rósa B. Barkardóttir Myrto Barrdahl Daniel R. Barnes Daniel Barrowdale Caroline Baynes Matthias W. Beckmann Javier Benı́tez Marina Bermisheva Leslie Bernstein Yves‐Jean Bignon Kathleen R. Blazer Marinus J. Blok Carl Blomqvist William J. Blot Kristie Bobolis Bram Boeckx Natalia Bogdanova Anders Bojesen Stig E. Bojesen Bernardo Bonanni Anne‐Lise Børresen‐Dale Anikó Bozsik Angela R. Bradbury Judith S. Brand Hiltrud Brauch Hermann Brenner Brigitte Bressac–de Paillerets Carole Brewer Louise A. Brinton Per Broberg Angela Brooks‐Wilson Joan Brunet Thomas Brüning Barbara Burwinkel Saundra S. Buys Jinyoung Byun Qiuyin Cai Trinidad Caldés Maria A. Caligo Ian Campbell Federico Canzian Olivier Caron Ángel Carracedo Brian D. Carter Jose E. Castelao Laurent Castéra Virginie Caux‐Moncoutier Salina Chan Jenny Chang‐Claude Stephen J. Chanock Xiaohong Chen Ting‐Yuan David Cheng Jocelyne Chiquette Hans Christiansen Kathleen Claes Christine L. Clarke Thomas Conner Don Conroy Jackie Cook

10.1038/ng.3785 article EN Nature Genetics 2017-10-23

10.1016/j.ajhg.2008.02.008 article EN publisher-specific-oa The American Journal of Human Genetics 2008-03-24
Yan Guo Shaneda Warren Andersen Xiao‐Ou Shu Kyriaki Michailidou Manjeet K. Bolla and 95 more Qin Wang Montserrat García‐Closas Roger L. Milne Marjanka K. Schmidt Jenny Chang‐Claude Alison M. Dunning Stig E. Bojesen Habibul Ahsan Kristiina Aittomäki Irene L. Andrulis Hoda Anton‐Culver Volker Arndt Matthias W. Beckmann Alicia Beeghly‐Fadiel Javier Benı́tez Natalia Bogdanova Bernardo Bonanni Anne‐Lise Børresen‐Dale Judith S. Brand Hiltrud Brauch Hermann Brenner Thomas Brüning Barbara Burwinkel Graham Casey Georgia Chenevix‐Trench Fergus J. Couch Angela Cox Simon S. Cross Kamila Czene Peter Devilee Thilo Dörk Martine Dumont Peter A. Fasching Jonine D. Figueroa Dieter Flesch‐Janys Olivia Fletcher Henrik Flyger Florentia Fostira Marilie D. Gammon Graham G. Giles Pascal Guénel Christopher A. Haiman Ute Hamann Maartje J. Hooning John L. Hopper Anna Jakubowska Farzana Jasmine Mark A. Jenkins Esther M. John Nichola Johnson Michael E. Jones Maria Kabisch Muhammad G. Kibriya Julia A. Knight Linetta B. Koppert Veli‐Matti Kosma Vessela N. Kristensen Loı̈c Le Marchand Eunjung Lee Jingmei Li Annika Lindblom Robert Luben Jan Lubiński Kathi Malone Graham J. Mann Sara Margolin Frederik Marmé Catriona McLean Hanne Meijers‐Heijboer Alfons Meindl Susan L. Neuhausen Heli Nevanlinna Patrick Neven Janet E. Olson José Ignacio Arias Pérez Barbara Perkins Paolo Peterlongo Kelly‐Anne Phillips Katri Pylkäs Anja Rudolph Regina M. Santella Elinor J. Sawyer Rita K. Schmutzler Caroline Seynaeve Mitul Shah Martha J. Shrubsole Melissa C. Southey Anthony J. Swerdlow Amanda E. Toland Ian Tomlinson Diana Torres Thérèse Truong Giske Ursin Rob B. van der Luijt Senno Verhoef

Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased postmenopausal women. It unclear whether this association mediated through shared genetic or environmental factors.

10.1371/journal.pmed.1002105 article EN cc-by PLoS Medicine 2016-08-23
Tracy A. O’Mara Dylan M. Glubb Frédéric Amant Daniela Annibali Katie A. Ashton and 95 more John Attia Paul L. Auer Matthias W. Beckmann Amanda Black Manjeet K. Bolla Hiltrud Brauch Hermann Brenner Louise A. Brinton Daniel D. Buchanan Barbara Burwinkel Jenny Chang‐Claude Stephen J. Chanock Chu Chen Maxine M. Chen Timothy Cheng Christine L. Clarke Mark Clendenning Linda S. Cook Fergus J. Couch Angela Cox Marta Crous‐Bou Kamila Czene Felix R. Day Joe Dennis Jeroen Depreeuw Jennifer A. Doherty Thilo Dörk Sean C. Dowdy Matthias Dürst Arif B. Ekici Peter A. Fasching Brooke L. Fridley Christine M. Friedenreich Lin Fritschi Jenny N. Fung Montserrat García‐Closas Mia M. Gaudet Graham G. Giles Ellen L. Goode Maggie Gorman Christopher A. Haiman Per Hall Susan E. Hankison Catherine S. Healey Alexander Hein Peter Hillemanns Shirley Hodgson Erling A. Høivik Elizabeth Holliday John L. Hopper David J. Hunter Angela Jones Camilla Krakstad Vessela N. Kristensen Diether Lambrechts Loı̈c Le Marchand Xiaolin Liang Annika Lindblom Jolanta Lissowska Jirong Long Lingeng Lu Anthony M. Magliocco Lynn Martin Mark McEvoy Alfons Meindl Kyriaki Michailidou Roger L. Milne Miriam Mints Grant W. Montgomery Rami Nassir Håkan Olsson Irene Orlow Geoffrey Otton Claire Palles John R. B. Perry Julian Peto Loreall Pooler Jennifer Prescott Tony Proietto Timothy R. Rebbeck Harvey A. Risch Peter A. W. Rogers Matthias Rübner Ingo B. Runnebaum Carlotta Sacerdote Gloria E. Sarto Fredrick R. Schumacher Rodney J. Scott Veronica Wendy Setiawan Mitul Shah Xin Sheng Xiao‐Ou Shu Melissa C. Southey Anthony J. Swerdlow Emma Tham

Endometrial cancer is the most commonly diagnosed of female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, present an expanded meta-analysis 12,906 cases and 108,979 controls (including new genotype data 5624 cases) identify nine novel significant loci, including a locus on 12q24.12 by meta-GWAS colorectal At five expression quantitative trait (eQTL) analyses candidate...

10.1038/s41467-018-05427-7 article EN cc-by Nature Communications 2018-08-03
Coming Soon ...