Roger L. Milne
- BRCA gene mutations in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic Associations and Epidemiology
- Cancer Risks and Factors
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Nutritional Studies and Diet
- Global Cancer Incidence and Screening
- Genetic factors in colorectal cancer
- Vitamin D Research Studies
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- Cancer survivorship and care
- Ovarian cancer diagnosis and treatment
- Estrogen and related hormone effects
- Breast Cancer Treatment Studies
- Pancreatic and Hepatic Oncology Research
- Genomic variations and chromosomal abnormalities
- RNA modifications and cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Birth, Development, and Health
- Bioinformatics and Genomic Networks
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Gene expression and cancer classification
The University of Melbourne
2016-2025
Monash University
2018-2025
Cancer Council Victoria
2016-2025
Monash Health
2018-2025
QIMR Berghofer Medical Research Institute
2010-2024
Spanish National Cancer Research Centre
2008-2023
Imperial College London
2021-2023
Centre International de Recherche sur le Cancer
2022-2023
University of Kansas Medical Center
2023
Murdoch Children's Research Institute
2023
<h3>Importance</h3> The clinical management of<i>BRCA1</i>and<i>BRCA2</i>mutation carriers requires accurate, prospective cancer risk estimates. <h3>Objectives</h3> To estimate age-specific risks of breast, ovarian, and contralateral breast for mutation to evaluate modification by family history location. <h3>Design, Setting, Participants</h3> Prospective cohort study 6036<i>BRCA1</i>and 3820<i>BRCA2</i>female (5046 unaffected 4810 with or ovarian both at baseline) recruited in 1997-2011...
Data for front-line health-care workers and risk of COVID-19 are limited. We sought to assess among compared with the general community effect personal protective equipment (PPE) on risk.
Background Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which turn may promote formation reactive oxygen species, promoting DNA damage expression key regulatory cancer genes. As uncontrolled proliferation are hallmarks cancer, including epithelial ovarian (EOC), we hypothesized that inherited variation genes contributes EOC risk. Methods In total, samples were obtained from 14,525 case subjects...
Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone (PR) expression status of the tumors.
Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 the risk of female cancer rs1314913 male cancer. The aim this study was investigate role RAD51B variants in predisposition, particularly context familial Finland. We sequenced coding region 168 Finnish patients from Helsinki for identification possible recurrent founder mutations. In addition, we studied known rs999737, rs2588809, SNPs haplotypes 44,791 cases 43,583 controls 40...
Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or the miRNA binding sites may affect dependent gene expression regulation, which has been implicated various cancers, including breast cancer, and alter individual susceptibility to cancer. We investigated associations between related SNPs cancer risk. First we evaluated 2,196 a case-control study combining nine genome wide association studies (GWAS). Second, further 42 with suggestive evidence for using...
Abstract Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank GWA consortia, we found that a one standard deviation increment average acceleration was (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) (OR: 0.66, CI: 0.48 0.90, 0.01)....
The rapid pace of the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) presents challenges to robust collection population-scale data address this global health crisis. We established COronavirus Pandemic Epidemiology (COPE) Consortium unite scientists with expertise in big research and epidemiology develop COVID Symptom Study, previously known as Tracker, mobile application. This application-which offers on risk factors, predictive...
A three-stage genome-wide association study recently identified single nucleotide polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (FGFR2), trinucleotide repeat containing 9 (TNRC9), mitogen-activated protein kinase 3 K1 (MAP3K1), 8q24, and lymphocyte-specific 1 (LSP1)) associated with breast cancer risk. We investigated whether the associations between these SNPs risk varied by clinically important tumor characteristics up to 23,039 invasive cases 26,273 controls from 20...
An improved model for risk stratification can be useful guiding public health strategies of breast cancer prevention.
The association between increasing body mass index (BMI; calculated as weight in kilograms divided by height meters squared) and risk of breast cancer is unique epidemiology that a crossover effect exists, with reduction before increase after menopause. inverse premenopausal poorly characterized but might be important the understanding causation.
Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased postmenopausal women. It unclear whether this association mediated through shared genetic or environmental factors.
Endometrial cancer is the most commonly diagnosed of female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, present an expanded meta-analysis 12,906 cases and 108,979 controls (including new genotype data 5624 cases) identify nine novel significant loci, including a locus on 12q24.12 by meta-GWAS colorectal At five expression quantitative trait (eQTL) analyses candidate...