Loreall Pooler
A5049518334- Genetic Associations and Epidemiology
- Hematopoietic Stem Cell Transplantation
- Prostate Cancer Treatment and Research
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Renal Transplantation Outcomes and Treatments
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- T-cell and B-cell Immunology
- Prostate Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Genetic factors in colorectal cancer
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- Genetic and phenotypic traits in livestock
- CAR-T cell therapy research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetic Mapping and Diversity in Plants and Animals
- Genomic variations and chromosomal abnormalities
- Chronic Myeloid Leukemia Treatments
- IL-33, ST2, and ILC Pathways
- Diabetes and associated disorders
- Genomics and Chromatin Dynamics
University of Southern California
2015-2024
Center for Human Genetics
2022
Fred Hutch Cancer Center
2022
Vanderbilt University Medical Center
2020
Centre Hospitalier Universitaire Pointe-à-Pitre
2020
Office of Public Health Genomics
2020
University of Virginia
2020
Stanford University
2016
Howard Hughes Medical Institute
2016
National Institutes of Health
2016
Endometrial cancer is the most commonly diagnosed of female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, present an expanded meta-analysis 12,906 cases and 108,979 controls (including new genotype data 5624 cases) identify nine novel significant loci, including a locus on 12q24.12 by meta-GWAS colorectal At five expression quantitative trait (eQTL) analyses candidate...
GWAS of prostate cancer have been remarkably successful in revealing common genetic variants and novel biological pathways that are linked with its etiology. A more complete understanding inherited susceptibility to the general population will come from continuing such discovery efforts testing known risk alleles diverse racial ethnic groups. In this large study African American men (3,425 cases 3,290 controls), we tested 49 located 28 genomic regions identified through European Asian...
The 8q24 region harbors multiple risk variants for distinct cancers, including >8 prostate cancer. In this study, we conducted fine mapping of the (127.8–128.8Mb) in search novel associations with common and rare variation 4853 cancer case patients 4678 control subjects African ancestry. All statistical tests were two-sided. We identified three independent at P values less than 5.00×10 –8 , all which replicated studies from Ghana Uganda (combined sample = 5869 patients, 5615 subjects;...
A rare African ancestry-specific germline deletion variant in HOXB13 (X285K, rs77179853) was recently reported Martinican men with early-onset prostate cancer. Given the role of variation cancer, we investigated association between X285K and cancer risk a large sample 22 361 ancestry men, including 11 688 cases. The allele present only West ancestry, an frequency that ranged from 0.40% Ghana 0.31% Nigeria to 0% Uganda South Africa, range frequencies admixed North America Europe (0-0.26%)....
Rare variation in protein coding sequence is poorly captured by GWAS arrays and has been hypothesized to contribute disease heritability. Using the Illumina HumanExome SNP array, we successfully genotyped 191,032 common rare non-synonymous, splice site, or nonsense variants a multiethnic sample of 2,984 breast cancer cases, 4,376 prostate 7,545 controls. In cancer, strongest associations included either SNPs gene burden scores for genes LDLRAD1, SLC19A1, FGFBP3, CASP5, MMAB, SLC16A6,...
Abstract Background There is an urgent need to identify factors specifically associated with aggressive prostate cancer (PCa) risk. We investigated whether rare pathogenic, likely or deleterious (P/LP/D) germline variants in DNA repair genes are PCa risk a case-case study of vs nonaggressive disease. Methods Participants were 5545 European-ancestry men, including 2775 and 2770 cases, which included 467 metastatic cases (16.9%). Samples assembled from 12 international studies sequenced...
Abstract Blood lipids have been associated with the development of a range cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies reported inconsistent associations between blood cancer risk. To reduce biases from unmeasured confounding, we performed bidirectional, two‐sample Mendelian randomization analysis to investigate relationship levels three (low‐density lipoprotein [LDL] high‐density [HDL] cholesterol, triglycerides) Genetic variants each...
Germline gene panel testing is recommended for men with advanced prostate cancer (PCa) or a family history of cancer. While evidence limited some genes currently included in testing, panels are also likely to be incomplete and missing that influence PCa risk aggressive disease.
Although men of African ancestry have a high risk prostate cancer (PCa), no genes or mutations been identified that contribute to familial clustering PCa in this population. We investigated whether the ancestry–specific variant at 8q24, rs72725854, is enriched with family history 9052 cases, 143 cases from high-risk families, and 8595 controls ancestry. found allele be significantly associated earlier age diagnosis, more aggressive disease, (32% carried vs 23% without 12% controls). For two...
Abstract Background: There have been few genome-wide association studies (GWAS) of prostate cancer among diverse populations. To search for novel risk variants, we conducted GWAS in Japanese and Latinos. In addition, tested variants developed genetic models Methods: Our first-stage included (cases/controls = 1,033/1,042) Latino 1,043/1,057) from the Multiethnic Cohort (MEC). Significant associations stage I (P < 1.0 × 10−4) were examined silico (stage II) 1,583/3,386) Europeans...
Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is most common gynecological malignancy in developed countries and fourth among US women. Women with family history EC have an increased risk for disease, suggesting that inherited genetic factors play role. We conducted two-stage genome-wide association study Type I EC. Stage 1 included 5,472 women (2,695 cases 2,777 controls) European ancestry from seven studies. selected independent single-nucleotide polymorphisms...
Abstract Statistical imputation applied to genome-wide array data is the most cost-effective approach complete catalog of genetic variation in a study population. However, imputed genotypes underrepresented populations incur greater inaccuracies due ascertainment bias and lack representation among reference individuals, further contributing obstacles these populations. Here we examined consequences by genotyping large number self-reported Native Hawaiians (N = 3693) functionally important,...
Studies in animals and humans clearly indicate a role for prolactin (PRL) breast epithelial proliferation, differentiation, tumorigenesis. Prospective epidemiological studies have also shown that women with higher circulating PRL levels an increase risk of cancer, suggesting variability may be important determining woman's risk. We evaluated genetic variation the receptor (PRLR) genes as predictors plasma cancer among African-American, Native Hawaiian, Japanese-American, Latina, White...