A5080523435- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Lung Cancer Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Hormonal and reproductive studies
- Cancer Risks and Factors
- Genetic Associations and Epidemiology
- Smoking Behavior and Cessation
- Cancer, Lipids, and Metabolism
- Head and Neck Cancer Studies
- Health disparities and outcomes
- Colorectal Cancer Screening and Detection
- Inflammatory Biomarkers in Disease Prognosis
- Glutathione Transferases and Polymorphisms
- Advanced Causal Inference Techniques
- Cervical Cancer and HPV Research
- Cardiovascular Health and Risk Factors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bladder and Urothelial Cancer Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Patient-Provider Communication in Healthcare
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Nutritional Studies and Diet
Temple University Health System
2024-2025
Fox Chase Cancer Center
2023-2025
Thomas Jefferson University
2014-2024
University of Pennsylvania
2005-2023
Sidney Kimmel Cancer Center
2014-2020
Philadelphia University
2020
Thomas Jefferson University Hospital
2014
Moffitt Cancer Center
2011
University of Southern California
2011
Johns Hopkins University
2011
Prostate cancer (CaP) is the leading among men of African descent in USA, Caribbean, and Sub-Saharan Africa (SSA). The estimated number CaP deaths SSA during 2008 was more than five times that Americans expected to double by 2030. We summarize publicly available data collected from Carcinoma (MADCaP) Consortium Caribbean Cancer (AC3) evaluate incidence mortality worldwide. are highest USA Caribbean. Tumor stage grade were SSA. report a higher proportion T1 prostate tumors countries with...
Germline testing (GT) is a central feature of prostate cancer (PCA) treatment, management, and hereditary assessment. Critical needs include optimized multigene strategies that incorporate evolving genetic data, consistency in GT indications alternate evaluation models address the rising demand for services. A multidisciplinary consensus conference included experts, stakeholders, national organization leaders was convened response to current practice challenges develop implementation...
Background The association between homocysteine and isolated systolic hypertension in older adults was evaluated using a case-control design, the relationship clinical or subclinical atherosclerosis explored. Methods Results Cases were 179 ≥60 years with blood pressure of ≥160 mm Hg diastolic <90 Hg. One hundred seventy-one control subjects had same criteria except pressures <160 All normal creatinine levels. Homocysteine levels performed on fasting samples that been stored at −70°C....
Abstract Background Racial disparities are well-documented in preventive cancer care, but they have not been fully explored the context of lung screening. We sought to explore racial differences screening outcomes within a program (LCSP) at our urban academic medical center including baseline low-dose computed tomography (LDCT) results, time follow-up, adherence, as well return annual after additional imaging, loss and diagnoses patients with positive scans. Methods A historical cohort study...
Abstract The CYP3A genes reside on chromosome 7q21 in a multigene cluster. enzyme products of CYP3A4 and CYP3A43 are involved testosterone metabolism. CYP3A5 have been associated previously with prostate cancer occurrence severity. To comprehensively examine the effects these severity, we studied 622 incident cases 396 controls. Substantial race-specific linkage disequilibrium was observed between both races but not other pairs loci. We found no association genotypes or disease CYP3A43*3...
Genome-wide association studies (GWAS) have identified numerous prostate cancer susceptibility alleles, but these loci been primarily in men of European descent. There is limited information about the role African
Genome-wide association studies have identified multiple genetic variants associated with prostate cancer risk which explain a substantial proportion of familial relative risk. These can be used to stratify individuals by their cancer.
<i>Objectives:</i> Ethnic differences in prostate cancer incidence are well documented, with African-Americans having among the highest rates world. genotypes for genes associated androgen metabolism including <i>SRD5A2</i> and <i>CYP3A4</i> also may exist. The aim of this study was to evaluate these by ethnicity. <i>Methods:</i> We studied cancer-free controls representative four groups: 147 African Americans, 410 Caucasian-Americans, 129...
Abstract Reported associations of ELAC2/HPC2, RNASEL/HPC1, and MSR1 with prostate cancer have been inconsistent understudied in African Americans. We evaluated the role 16 sequence variants these genes using 888 European American 131 cases, 473 163 American, controls. observed significant differences ELAC2, RNASEL, allele frequencies by race. However, we did not observe between any examined for both races combined. Associations were when stratified race, family history, or disease severity....
No AccessJournal of UrologyAdult urology1 Nov 2007Association Obesity With Tumor Characteristics and Treatment Failure Prostate Cancer in African-American European American Menis accompanied byObesity Cancer: Importance Race Stage Disease E. Spangler, C.M. Zeigler-Johnson, M. Coomes, S.B. Malkowicz, A. Wein, T.R. Rebbeck SpanglerE. Spangler Center for Clinical Epidemiology Biostatistics, University Pennsylvania School Medicine, Philadelphia, , Zeigler-JohnsonC.M. Zeigler-Johnson CoomesM....
(1) Background: Lung cancer is the deadliest and second most prevalent in Pennsylvania (PA), African American patients are disproportionately affected. morbidity mortality Philadelphia County among highest PA. Geographic information systems (GIS) useful to explore geospatial variations burden risk factors. Therefore, we used GIS analyze lung assess which areas of city have mortality, identify potential clusters, determine census tract-level characteristics were associated with higher burden....
Purpose To identify the barriers and facilitators to help seeking, screening for early presentation diagnosis of prostate cancer in Kenya. Methods Seven focus group discussions (FGDs) were held with a total 46 patients diagnosed living cancer, 65% ( n = 30) from public Hospital 35% 16) private hospital. An FGD guide was used collect data on patients' screening, diagnosis. Results The distributed across different age groups: 4.3 % 2) aged 50–59, 41% 19) 60–69, 54% 25) 70 above. majority 7 th...
Abstract Background: Cervical cancer is the most prevalent and leading cause of cancer-related deaths among women in Eswatini, which reported world’s highest cervical incidence (95.9 per 100,000) mortality (64.3 rates 2022. Despite this significant burden, screening coverage was limited to 19% as WHO’s 2019 report. This study assessed progress prevalence identified predictors uptake aged 25-59 Eswatini. Method: Data were obtained from 2021 Eswatini Population-based HIV Impact Assessment...
Abstract The lung cancer mortality rate in Philadelphia is 16% higher than the national rate, making screening and prevention efforts paramount. To support efforts, Fox Chase Cancer Center operates a comprehensive Tobacco Treatment Program (TTP) that employs an Implementation Science (IS) approach provides over 1000 individuals with various therapeutic strategies to smoking cessation. Using TTP as case study, this brief report describes adaptation of Reach, Effectiveness, Adoption,...
Background Population history can be reflected in group genetic ancestry, where genomic variation captured by the mitochondrial DNA (mtDNA) and non-recombining portion of Y chromosome (NRY) separate female- male-specific admixture processes. Genetic ancestry may influence association studies due to differences individual within recently admixed populations like African Americans. Principal Findings We evaluated Senegalese as well European Americans from Philadelphia. mtDNA consisted ∼12% U...
Patient reports of health related quality life can provide important information about the long-term impact prostate cancer. Because patient symptoms and function differ by age survivor, aim our study was to examine patient-reported at diagnosis among a registry Dutch cancer survivors.A population 617 individuals from Reported Outcomes Following Initial Treatment Long-Term Evaluation Survivorship (PROFILES) database surveyed using European Organization for Research Cancer Quality Life...
Abstract Background Lung cancer screening uptake for individuals at high risk is generally low across the United States, and reporting of lung practices outcomes often limited to single hospitals or institutions. We describe a citywide, multicenter analysis receiving integrated with geospatial analyses neighborhood-level factors. Methods The Philadelphia Cancer Learning Community consists clinicians researchers 3 largest health systems in city. This multidisciplinary, multi-institutional...
Prostate cancer disparities have been reported in men of African descent who show the highest incidence, mortality, compared with other ethnic groups. Few studies explored genetic and environmental factors for prostate ancestry. The glutathione-S-transferases family conjugates carcinogens before their excretion is expressed tissue. This study addressed role GSTM1 GSTT1 deletions on risk populations descent. multi-institutional case-control gathered data from Genetic Susceptibility to...