Sarah J. Nyante
A5010322536- Global Cancer Incidence and Screening
- BRCA gene mutations in cancer
- Genetic Associations and Epidemiology
- Breast Cancer Treatment Studies
- Cancer Risks and Factors
- Cervical Cancer and HPV Research
- Breast Lesions and Carcinomas
- Digital Radiography and Breast Imaging
- Genomic variations and chromosomal abnormalities
- Nutrition, Genetics, and Disease
- AI in cancer detection
- Estrogen and related hormone effects
- Cancer Genomics and Diagnostics
- Genetic and phenotypic traits in livestock
- COVID-19 and healthcare impacts
- Genetics, Bioinformatics, and Biomedical Research
- Cancer-related molecular mechanisms research
- Gene expression and cancer classification
- Epigenetics and DNA Methylation
- Infrared Thermography in Medicine
- Colorectal Cancer Screening and Detection
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Health Systems, Economic Evaluations, Quality of Life
- Medical Imaging Techniques and Applications
University of North Carolina at Chapel Hill
2015-2024
UNC Lineberger Comprehensive Cancer Center
2011-2021
Public Health Department
2008-2021
National Cancer Institute
2010-2017
Division of Cancer Epidemiology and Genetics
2011-2017
Indiana University School of Medicine
2017
Kaiser Permanente Washington Health Research Institute
2015-2016
Kaiser Permanente Center for Health Research
2015-2016
The University of Texas Health Science Center at San Antonio
2016
National Institutes of Health
2010-2015
RNA-based, multi-gene molecular assays are available and widely used for patients with ER-positive/HER2-negative breast cancers. However, RNA-based genomic tests can be costly not in many countries. Methods inferring subtype from histologic images may identify most likely to benefit further testing. To who could testing based on H&E stained images, we developed an image analysis approach using deep learning. A training set of 571 tumors was create image-based classifiers tumor grade, ER...
The coronavirus disease 2019 (COVID-19) pandemic has disrupted breast cancer control through short-term declines in screening and delays diagnosis treatments. We projected the impact of COVID-19 on future mortality between 2020 2030.Three established Cancer Intervention Surveillance Modeling Network models modeled reductions mammography use, symptomatic diagnosis, reduced use chemotherapy for women with early-stage first 6 months return to prepandemic patterns after that time. Sensitivity...
Lobular carcinoma in situ (LCIS) of the breast is considered a marker for an increased risk both breasts. However, frequent association LCIS with invasive lobular (ILC) suggests precursor-product relation. The possible genomic relation between synchronous and ILC was analyzed using technique array-based comparative hybridization (CGH).Twenty-four samples from University California-San Francisco pathology archives that contained were identified. Array CGH performed random primer-amplified...
Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted genome-wide association study (GWAS) distribution among those predominantly African ancestry (AA). We performed GWAS WC and WHR, adjusted unadjusted for BMI, in up to 33,591 27,350 AA individuals, respectively. identified loci associated with individuals using meta-analyses GWA...
While genome-wide association studies (GWAS) have primarily examined populations of European ancestry, more recent often involve additional populations, including admixed such as African Americans and Latinos. In linkage disequilibrium (LD) exists both at a fine scale in ancestral coarse (admixture-LD) due to chromosomal segments distinct ancestry. Disease statistics previously considered SNP (LD mapping) or admixture (mapping by admixture-LD), but not both. Here, we introduce new...
BACKGROUND To understand how health care delays may affect breast cancer detection, the authors quantified changes in breast‐related preventive and diagnostic during coronavirus disease 2019 (COVID‐19) pandemic. METHODS Eligible women (N = 39,444) were aged ≥18 years received a screening mammogram, or biopsy between January 1, September 30, 2020, at 7 academic community imaging facilities North Carolina. Changes number of mammography examinations after March 3, 2020 (the first COVID‐19...
Twenty-nine single-nucleotide polymorphisms (SNPs) from previously published genome-wide association studies (GWAS) and multiple ancestry informative markers were genotyped in the Carolina Breast Cancer Study (CBCS) (742 African-American (AA) cases, 1230 White cases; 658 AA controls, 1118 controls). In entire study population, 9/10 SNPs fibroblast growth factor receptor 2 ( FGFR2 ) significantly associated with breast cancer after adjusting for age, race European [odds ratios (OR) range...
Sex steroid hormones and inflammatory biomarkers are both associated with the development progression of chronic diseases, but their interrelationship is relatively uncharacterized. We examined association sex hormone-binding globulin (SHBG) inflammation, C-reactive protein (CRP) white blood cell (WBC) count. The study included data from 809 adult men in National Health Nutrition Examination Survey 1999–2004. Geometric means 95% confidence intervals were estimated separately for CRP WBC...
The 2014 US Surgeon General's report noted research gaps necessary to determine a causal relationship between active cigarette smoking and invasive breast cancer risk, including the role of alcohol consumption, timing exposure, modification by menopausal status heterogeneity oestrogen receptor (ER) status.To address these issues, we pooled data from 14 cohort studies contributing 934 681 participants (36 060 cases). Cox proportional hazard regression models were used calculate...
Postmenopausal obesity is associated with increased circulating levels of androgens and estrogens elevated breast cancer risk. Crown-like structures (CLS; microscopic foci dying adipocytes surrounded by macrophages) are proposed to represent sites aromatization estrogens. Accordingly, we examined relationships between CLS sex-steroid hormones in adipose tissue serum from postmenopausal patients. Formalin-fixed paraffin embedded benign tissues collected for research women (n = 83) diagnosed...
Abstract Background Polygenic risk scores (PRSs) have been demonstrated to identify women of European, Asian, and Latino ancestry at elevated developing breast cancer (BC). We evaluated the performance existing PRSs trained in European populations among African ancestry. Methods assembled genotype data for ancestry, including 9241 case subjects 10 193 control subjects. associations 179- 313-variant with overall subtype-specific BC risk. PRS discriminatory accuracy was assessed using area...
Genome-wide association studies (GWAS) have revealed 19 common genetic variants that are associated with breast cancer risk. Testing of the index signals found through GWAS and fine-mapping each locus in diverse populations will be necessary for characterizing role these risk regions contributing to inherited susceptibility. In this large study African-American women (3016 cases 2745 controls), we tested known identified by replicated associations (P < 0.05) only 4 variants. Through...