Jennifer A. Doherty
A5075544315- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- BRCA gene mutations in cancer
- Epigenetics and DNA Methylation
- Cancer Risks and Factors
- Ferroptosis and cancer prognosis
- PARP inhibition in cancer therapy
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Estrogen and related hormone effects
- Gene expression and cancer classification
- Molecular Biology Techniques and Applications
- Bioinformatics and Genomic Networks
- Nutrition, Genetics, and Disease
- Cancer, Lipids, and Metabolism
- DNA Repair Mechanisms
- Telomeres, Telomerase, and Senescence
- CRISPR and Genetic Engineering
- Virus-based gene therapy research
- Cancer Immunotherapy and Biomarkers
- Reproductive System and Pregnancy
University of Utah
2017-2025
Huntsman Cancer Institute
2017-2025
Intermountain Healthcare
2022-2025
Dartmouth College
2013-2024
Huntsman (United States)
2024
Fred Hutch Cancer Center
2012-2023
National Cancer Institute
2010-2022
Cancer Research Center
2005-2022
University of Hawaii System
2010-2022
Moffitt Cancer Center
2010-2022
Somatic mutations in the tyrosine kinase (TK) domain of epidermal growth factor receptor (EGFR) gene are reportedly associated with sensitivity lung cancers to gefitinib (Iressa), inhibitor. In-frame deletions occur exon 19, whereas point frequently codon 858 (exon 21). We found from sequencing EGFR TK that 7 10 gefitinib-sensitive tumors had similar types alterations; no were eight gefitinib-refractory ( P = 0.004). Five seven sensitive erlotinib (Tarceva), a related inhibitor for which...
Background Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which turn may promote formation reactive oxygen species, promoting DNA damage expression key regulatory cancer genes. As uncontrolled proliferation are hallmarks cancer, including epithelial ovarian (EOC), we hypothesized that inherited variation genes contributes EOC risk. Methods In total, samples were obtained from 14,525 case subjects...
Endometriosis is a risk factor for epithelial ovarian cancer; however, whether this extends to all invasive histological subtypes or borderline tumours not clear. We undertook an international collaborative study assess the association between endometriosis and of cancer.
Background Assessing the relationship between lung cancer and metabolic conditions is challenging because of confounding effect tobacco. Mendelian randomization (MR), or use genetic instrumental variables to assess causality, may help identify drivers cancer. Methods findings We identified instruments for potential risk factors evaluated these in relation using 29,266 cases (including 11,273 adenocarcinomas, 7,426 squamous cell 2,664 small cases) 56,450 controls. The MR analysis suggested a...
The understanding of ovarian cancer pathogenesis has recently shifted to recognize distinct changes in how histotypes are defined. Using the 2014 World Health Organization (WHO) diagnostic guidelines, we classified Surveillance, Epidemiology, and End Results (SEER) registry data examined survival patterns by histotype disease stage. We extracted on 28 118 incident epithelial cases diagnosed 2004–2014 from SEER defined using WHO guidelines (high-grade serous, low-grade endometrioid, clear...
Telomere length within an individual varies in a correlated manner across most tissues.
Endometrial cancer is the most commonly diagnosed of female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, present an expanded meta-analysis 12,906 cases and 108,979 controls (including new genotype data 5624 cases) identify nine novel significant loci, including a locus on 12q24.12 by meta-GWAS colorectal At five expression quantitative trait (eQTL) analyses candidate...
Whilst previous studies have reported that higher BMI increases a woman's risk of developing ovarian cancer, associations for the different histological subtypes not been well defined. As prevalence obesity has increased dramatically, and classification histology improved in last decade, we sought to examine association pooled analysis recent participating Ovarian Cancer Association Consortium. We evaluated between (recent, maximum young adulthood) cancer using original data from 15...
Abstract Breast, ovarian, and prostate cancers are hormone-related may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these totaling 112,349 cases 116,421 controls of European ancestry, all together in pairs, identified at P < 10−8 seven new cross-cancer loci: three associated with susceptibility to (rs17041869/2q13/BCL2L11;...
Bidirectional Encoder Representations from Transformers (BERT) and BERT-based approaches are the current state-of-the-art in many natural language processing (NLP) tasks; however, their application to document classification on long clinical texts is limited. In this work, we introduce four methods scale BERT, which by default can only handle input sequences up approximately 400 words long, perform several thousand long. We compare these against two much simpler architectures - a word-level...
Endometriosis has been associated with an increased risk of ovarian cancer; however, the associations between endometriosis subtypes and cancer histotypes have not well-described.
Background Tubal ligation is a protective factor for ovarian cancer, but it unknown whether this protection extends to all invasive histological subtypes or borderline tumors. We undertook an international collaborative study examine the association between tubal and cancer subtypes. Methods pooled primary data from 13 population-based case-control studies, including 10 157 patients with (7942 invasive; 2215 borderline) 904 control women. Invasive cases were analysed by type, grade stage,...
Epidemiological studies have reported inconsistent associations between telomere length (TL) and risk for various cancers.These inconsistencies are likely attributable, in part, to biases that arise due post-diagnostic post-treatment TL measurement.To avoid such biases, we used a Mendelian randomization approach estimated nine TL-associated SNPs five common cancer types (breast, lung, colorectal, ovarian prostate cancer, including subtypes) using data on 51 725 cases 62 035 controls.We then...
<h3>Importance</h3> Breastfeeding has been associated with a reduced risk of epithelial ovarian cancer in multiple studies, but others showed no association. Whether reduction extends beyond that provided by pregnancy alone or differs histotype is unclear. Furthermore, the observed associations between duration and timing breastfeeding have inconsistent. <h3>Objective</h3> To determine association (ie, ever/never, duration, timing) overall histotype. <h3>Design, Setting, Participants</h3> A...
Background:In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between ovarian is uncertain, with generating conflicting findings. A potential limitation of inadequate control confounding. To overcome this problem, we used Mendelian randomization (MR) to evaluate association single nucleotide polymorphisms (SNPs) associated circulating 25-hydroxyvitamin [25(OH)D] concentration risk cancer. Methods: We...