Kirsten B. Moysich
A5057283450- Ovarian cancer diagnosis and treatment
- Cancer Risks and Factors
- Endometrial and Cervical Cancer Treatments
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- BRCA gene mutations in cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Genomics, phytochemicals, and oxidative stress
- Inflammatory mediators and NSAID effects
- Multiple Myeloma Research and Treatments
- Estrogen and related hormone effects
- Endometriosis Research and Treatment
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Tryptophan and brain disorders
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Glutathione Transferases and Polymorphisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Epigenetics and DNA Methylation
- Nutritional Studies and Diet
- Toxic Organic Pollutants Impact
- Childhood Cancer Survivors' Quality of Life
- Head and Neck Cancer Studies
Roswell Park Comprehensive Cancer Center
2016-2025
Cancer Genetics (United States)
2009-2023
National Cancer Institute
2000-2022
University of Hawaii System
2010-2022
Cancer Research Center
2010-2022
Moffitt Cancer Center
2022
Huntsman Cancer Institute
2022
American Cancer Society
2022
University at Buffalo, State University of New York
1998-2017
Heritage Foundation
2017
Endometriosis is a risk factor for epithelial ovarian cancer; however, whether this extends to all invasive histological subtypes or borderline tumours not clear. We undertook an international collaborative study assess the association between endometriosis and of cancer.
Cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic patterns TILs by histotype and relation to other clinical factors.
We evaluated the overall and site-specific incidence of cancer in subjects with primary immunodeficiency diseases (PIDD) enrolled United States Immune Deficiency Network (USIDNET) registry compared age-adjusted Surveillance, Epidemiology End Results Program (SEER) database.
Abstract Breast cancer in men is a rare disease, accounting for ∼1% of all breast cases. Although the epidemiologic literature regarding female extensive, relatively little known about etiology male (MBC). This review intended to summarize existing body evidence on genetic and risk factors men. Overall, epidemiology MBC presents similarities with cancer. Major associated an increased include BRCA2 mutations, which are believed account majority inherited men, Klinefelter syndrome, positive...
Abstract Abstract: Cruciferous vegetables contain anticarcinogenic isothiocyanates (ITCs), particularly the potent sulforaphane, which may decrease risk of prostate cancer through induction phase II enzymes, including glutathione S-transferases (GSTs). We evaluated this hypothesis in a population-based, case-control study cancer, 428 men with incident and 537 community controls. An in-person interview included an extensive food-frequency questionnaire. Genotyping for deletions GSTM1 GSTT1...
Background Tubal ligation is a protective factor for ovarian cancer, but it unknown whether this protection extends to all invasive histological subtypes or borderline tumors. We undertook an international collaborative study examine the association between tubal and cancer subtypes. Methods pooled primary data from 13 population-based case-control studies, including 10 157 patients with (7942 invasive; 2215 borderline) 904 control women. Invasive cases were analysed by type, grade stage,...
Abstract Cruciferous vegetables contain isothiocyanates, which show potent chemopreventive activity against bladder cancer in both vitro and vivo studies. However, previous epidemiologic studies investigating cruciferous vegetable intake risk have been inconsistent. Cooking can substantially reduce or destroy could account for study inconsistencies. In this hospital-based case-control involving 275 individuals with incident, primary 825 without cancer, we examined the usual prediagnostic of...
Abstract It has been reported that levo-1-methyl tryptophan (L-1MT) can block indoleamine-2,3-dioxygenase (IDO) expressed by human dendritic cells (DC), whereas dextro-1-methyl (D-1MT) is inefficient. However, whether L-1MT or D-1MT efficiently reverse IDO-induced arrest of T-cell proliferation not clarified. Here, we show a marked immunosuppressive effect IDO derived from INDO-transfected 293 cell, IDO+ ovarian cancer cells, and monocyte-derived DCs on CD4+ Th1 CD8+ T natural killer...
<h3>Importance</h3> Breastfeeding has been associated with a reduced risk of epithelial ovarian cancer in multiple studies, but others showed no association. Whether reduction extends beyond that provided by pregnancy alone or differs histotype is unclear. Furthermore, the observed associations between duration and timing breastfeeding have inconsistent. <h3>Objective</h3> To determine association (ie, ever/never, duration, timing) overall histotype. <h3>Design, Setting, Participants</h3> A...
Background: Periodontal pathogens have been isolated from precancerous and cancerous lesions also shown to promote a procarcinogenic microenvironment. Few studies examined periodontal disease as risk factor for total cancer, none focused on older women. We whether is associated with incident cancer among postmenopausal women in the Women's Health Initiative Observational Study.Methods: Our prospective cohort study comprised 65,869 women, ages 54 86 years. information was obtained via...
Epithelial ovarian cancer (EOC) often presents with metastases and ascites. Granulocytic myeloid-derived suppressor cells are an immature population that impairs antitumor immunity. Since suppressive granulocytes in the ascites of patients newly diagnosed EOC were morphologically mature, we hypothesized PMN rendered tumor microenvironment (TME). Circulating from not but acquired a phenotype (defined as ≥1 log10 reduction anti-CD3/CD28-stimulated T cell proliferation) after supernatant...
Abstract Genome-wide association studies (GWAS) have led to the identification of hundreds susceptibility loci across cancers, but impact further remains uncertain. Here we analyse summary-level data from GWAS European ancestry fourteen cancer sites estimate number common variants (polygenicity) and underlying effect-size distribution. All cancers show a high degree polygenicity, involving at minimum thousands loci. We project that sample sizes required explain 80% heritability vary 60,000...
A number of epidemiological studies have suggested that diet may affect the etiology prostate cancer, but few investigated impact phytochemical intakes on this cancer. We conducted a case-control study and cancer in western New York involving 433 men with primary, histologically confirmed 538 population-based controls, frequency matched to cases age county residence. Diet was assessed detailed food-frequency questionnaire. calculated daily nutrients phytochemicals beta-sitosterol,...
Background: Environmental exposure to organochlorines has been examined as a potential risk factor for breast cancer. In 1993, five large U.S. studies of women located mainly in the northeastern United States were funded evaluate association levels 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (DDE) and polychlorinated biphenyls (PCBs) blood plasma or serum with cancer risk. We present combined analysis these results increase precision maximize statistical power detect effect modification by...
Abstract Background: Intake of cruciferous vegetables, a rich source dietary isothiocyanates, has been inversely associated with risk bladder cancer. Due to the potent antiproliferative effects isothiocyanates on cancer in vitro and vivo models, vegetable intake may also play role survival among patients Methods: Using information obtained from Roswell Park Cancer Institute Tumor Registry, patient medical records, routinely collected questionnaire data, we examined potential associations...