A5029243196- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Immune cells in cancer
- BRCA gene mutations in cancer
- Cancer Risks and Factors
- Endometriosis Research and Treatment
- Pain Management and Opioid Use
- Anesthesia and Pain Management
- Intraperitoneal and Appendiceal Malignancies
- Reproductive System and Pregnancy
- Cancer, Lipids, and Metabolism
- Acute Myocardial Infarction Research
- Genetic factors in colorectal cancer
- Viral-associated cancers and disorders
- Cervical Cancer and HPV Research
- Neuroendocrine Tumor Research Advances
- Chemotherapy-induced organ toxicity mitigation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Lung Cancer Research Studies
- Venous Thromboembolism Diagnosis and Management
- Breast Implant and Reconstruction
- Reproductive Biology and Fertility
- Economic and Financial Impacts of Cancer
- Vascular Tumors and Angiosarcomas
Kaiser Permanente
2023
Roswell Park Comprehensive Cancer Center
2016-2019
Indiana University School of Medicine
2015
Indiana University – Purdue University Indianapolis
2015
York District Hospital
2002
CancerCare
2002
The Christie Hospital
1990
We evaluated the overall and site-specific incidence of cancer in subjects with primary immunodeficiency diseases (PIDD) enrolled United States Immune Deficiency Network (USIDNET) registry compared age-adjusted Surveillance, Epidemiology End Results Program (SEER) database.
<h3>Importance</h3> Opioids are routinely prescribed for postoperative home pain management most patients in the United States, with limited evidence of amount needed to be dispensed. Opioid-based treatment often adversely affects recovery. Prescribed opioids increase risk chronic opioid use, abuse, and diversion contribute current epidemic. <h3>Objective</h3> To evaluate whether after hospital discharge, postsurgical acute can effectively managed a markedly reduced number doses. <h3>Design,...
Epithelial ovarian cancer (EOC) often presents with metastases and ascites. Granulocytic myeloid-derived suppressor cells are an immature population that impairs antitumor immunity. Since suppressive granulocytes in the ascites of patients newly diagnosed EOC were morphologically mature, we hypothesized PMN rendered tumor microenvironment (TME). Circulating from not but acquired a phenotype (defined as ≥1 log10 reduction anti-CD3/CD28-stimulated T cell proliferation) after supernatant...
Advanced cancer causes necrosis and releases damage-associated molecular patterns (DAMPs). Mitochondrial DAMPs activate neutrophils, including generation of neutrophil extracellular traps (NETs), which are injurious, thrombogenic, implicated in metastasis. We hypothesised that mitochondrial DNA (mtDNA) ascites from patients with epithelial ovarian (EOC) would correlate worse outcomes.Banked supernatants newly diagnosed advanced EOC were analysed for mtDNA, elastase, activation healthy donor...
• Secondary, reversion mutations in BRCA genes can restore protein function. Reversion underlie resistance to therapies such as PARP inhibitors. arise during the course of treatment.
Campylobacter jejuni frequently infects humans causing many gastrointestinal symptoms, fever, fatigue and several long-term debilitating diseases. Current treatment for campylobacteriosis includes rehydration in some cases, antibiotic therapy. Probiotics are used to treat Butyrate is a short-chain fatty acid known promote intestinal health. Interaction of butyrate with its respective receptor (HCAR2) transporter (SLC5A8), both expressed the intestine, associated water electrolyte absorption...
Findings from in vitro studies suggest that increased exposure to thyroid hormones can influence progression of ovarian tumours. However, epidemiologic evidence on this topic is limited.
Objective In this study, we investigated whether physical inactivity was associated with risk of cervical cancer in women treated at an American hospital. Methods This case-control study included 128 patients and 512 controls matched on age. Controls were suspected having but not ultimately diagnosed a neoplasm. Physical defined accordance the 2008 Activity Guidelines for Americans. Thus, participants reporting, average, no moderate or vigorous recreational activity classified as inactive....
<h3>Objective</h3> There is a mounting body of evidence demonstrating higher percentages regulatory T (Treg) cells in the peripheral blood patients with cancer comparison to healthy controls, but there paucity epidemiological literature characterizing circulating Treg among epithelial ovarian (EOC). To investigate role neoplasms, we conducted case–control study characterize concentrations EOC, women benign conditions, and controls without history cancer. <h3>Materials Methods</h3>...
Abstract Background: Comorbidities can affect survival of ovarian cancer patients by influencing treatment efficacy. However, little evidence exists on the association between individual concurrent comorbidities and prognosis in patients. Methods: Among diagnosed with invasive carcinoma who participated 23 studies included Ovarian Cancer Association Consortium, we explored associations histories endometriosis; asthma; depression; osteoporosis; autoimmune, gallbladder, kidney, liver,...
Large-amplitude circadian rhythms in immune responses and the known variations effects of glucocorticoids with time day administration suggest that immunosuppressive regimens may need to take this variable into account. In two similar groups patients renal transplants functioning satisfactorily after three months subsequent graft failure developed 66% those taking all immunosuppressives evening, compared only 22% twice daily (p < 0.05). A survey other transplant units showed one unit...
1520 Background: We reported the overall and site-specific incidence of cancer in United States Immune Deficiency Network (USIDNET) Registry.We hypothesized that patients with Primary Immunodeficiency Diseases will have an increased due to impaired immune function. Methods: Data were abstracted from USIDNET Registry (n = 3,665) 2003 2015. Site-specific rates generated for within registry. Age adjusted using SEER database comparison Results: observed a 1.34-fold excess relative risk (p <...
5551 Background: Tumors with genomic alteration (GA) of BRCA1 or BRCA2 ( BRCA) may be more sensitive to platinum (Pt) therapies and PARP inhibitors (PARPi). However, secondary reversion mutations (revGA) can arise that restore BRCA function underlie reduced sensitivity Pt compounds PARPi. Methods: DNA extracted from FFPE tumor tissue blood samples obtained during routine clinical care for patients predominantly relapsed, refractory metastatic breast cancer (10967) ovarian/peritoneal (8352)...