Allan Jensen
A5008310706- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- BRCA gene mutations in cancer
- Cancer-related molecular mechanisms research
- Cancer Risks and Factors
- Reproductive Biology and Fertility
- Genetic Associations and Epidemiology
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian function and disorders
- RNA modifications and cancer
- RNA Research and Splicing
- Reproductive System and Pregnancy
- Reproductive Health and Technologies
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Screening and Detection
- Nonmelanoma Skin Cancer Studies
- Global Cancer Incidence and Screening
- Nutrition, Genetics, and Disease
- Kruppel-like factors research
- Prenatal Screening and Diagnostics
- Genetic factors in colorectal cancer
- PARP inhibition in cancer therapy
- Cutaneous Melanoma Detection and Management
Danish Cancer Society
2016-2025
Rigshospitalet
2009-2025
Copenhagen University Hospital
2014-2025
Aarhus University Hospital
2009-2025
Lundbeck (Denmark)
2024-2025
Danish Multiple Sclerosis Center
2025
Cancer Institute (WIA)
2024
Jazz Pharmaceuticals (United States)
2023
Karyopharm Therapeutics (United States)
2023
Bristol-Myers Squibb (Germany)
2023
Background Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which turn may promote formation reactive oxygen species, promoting DNA damage expression key regulatory cancer genes. As uncontrolled proliferation are hallmarks cancer, including epithelial ovarian (EOC), we hypothesized that inherited variation genes contributes EOC risk. Methods In total, samples were obtained from 14,525 case subjects...
Endometriosis is a risk factor for epithelial ovarian cancer; however, whether this extends to all invasive histological subtypes or borderline tumours not clear. We undertook an international collaborative study assess the association between endometriosis and of cancer.
Cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic patterns TILs by histotype and relation to other clinical factors.
The aim of this study was to estimate the contribution deleterious mutations in RAD51B, RAD51C, and RAD51D genes invasive epithelial ovarian cancer (EOC) population a screening trial individuals at high risk cancer.
Whilst previous studies have reported that higher BMI increases a woman's risk of developing ovarian cancer, associations for the different histological subtypes not been well defined. As prevalence obesity has increased dramatically, and classification histology improved in last decade, we sought to examine association pooled analysis recent participating Ovarian Cancer Association Consortium. We evaluated between (recent, maximum young adulthood) cancer using original data from 15...
BackgroundATP-binding cassette (ABC) transporters play various roles in cancer biology and drug resistance, but their association with outcomes serous epithelial ovarian (EOC) is unknown.
Nonmelanoma skin cancer (NMSC) is the most common among Caucasian populations worldwide, and incidence rates are increasing. However, NMSC data not routinely collected by registries, but Denmark has extensive registration of in two nationwide population-based registries. We assessed trends from 1978 to 2007. Data for basal cell carcinoma (BCC) squamous (SCC) were obtained Danish Cancer Registry Pathology. For both genders, age-specific overall rates, age-adjusted according World standard...
Background Tubal ligation is a protective factor for ovarian cancer, but it unknown whether this protection extends to all invasive histological subtypes or borderline tumors. We undertook an international collaborative study examine the association between tubal and cancer subtypes. Methods pooled primary data from 13 population-based case-control studies, including 10 157 patients with (7942 invasive; 2215 borderline) 904 control women. Invasive cases were analysed by type, grade stage,...
HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing serous leading us to hypothesize that variation this gene differentially associates with cancer risk according histological subtype. Here comprehensively map respect analyse DNA methylation expression profiles across subtypes. Different single-nucleotide polymorphisms associate invasive (rs7405776 odds ratio (OR)=1.13, P=3.1 × 10−10) (rs11651755 OR=0.77, P=1.6 10−8) cancer. Risk alleles for...
To analyze the effect of germline mutations in BRCA1 and BRCA2 on mortality patients with ovarian cancer up to 10 years after diagnosis.
In Brief OBJECTIVE: To investigate the association between cone depth of loop electrosurgical excision procedure (LEEP) cervix and subsequent risk spontaneous preterm delivery. METHODS: The study included all deliveries in Denmark over a 9-year period, 1997-2005, with information obtained from various public health registries. Of 552,678 singleton study, 19,049 were 8,180 to LEEP. prior LEEP, 273 two or more LEEPs. only one we extracted about on 3,605 deliveries, which 223 (6.2%). Logistic...
The purpose of this study was to estimate precise age-specific tubo-ovarian carcinoma (TOC) and breast cancer (BC) risks for carriers pathogenic variants in RAD51C RAD51D.
<b>Objective</b> To examine the effects of fertility drugs on overall risk ovarian cancer using data from a large cohort infertile women. <b>Design</b> Population based study. <b>Setting</b> Danish hospitals and private clinics. <b>Participants</b> 54 362 women with infertility problems referred to all clinics during 1963-98. The median age at first evaluation was 30 years (range 16-55 years), end follow-up 47 18-81) years. Included in analysis were 156 invasive epithelial (cases) 1241...
Confounding from comorbidity and socioeconomic status may have biased earlier findings of all-cause mortality among patients with basal cell carcinoma (BCC) squamous (SCC). We therefore examined 72,295 Danish BCC, 11,601 SCC, 383,714 age- gender-matched population control cohort subjects extensive for status. Data on cancer, death, were obtained medical databases Statistics Denmark. analysed data using Cox regression analysis, estimation 10-year rate ratios (MRRs) 95% confidence intervals...
<h3>Importance</h3> Breastfeeding has been associated with a reduced risk of epithelial ovarian cancer in multiple studies, but others showed no association. Whether reduction extends beyond that provided by pregnancy alone or differs histotype is unclear. Furthermore, the observed associations between duration and timing breastfeeding have inconsistent. <h3>Objective</h3> To determine association (ie, ever/never, duration, timing) overall histotype. <h3>Design, Setting, Participants</h3> A...
Background:In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between ovarian is uncertain, with generating conflicting findings. A potential limitation of inadequate control confounding. To overcome this problem, we used Mendelian randomization (MR) to evaluate association single nucleotide polymorphisms (SNPs) associated circulating 25-hydroxyvitamin [25(OH)D] concentration risk cancer. Methods: We...
Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized the 3′ untranslated region at putative microRNA (miRNA)-binding sites represent functional targets influence EOC susceptibility. Here, we evaluate association between 767 miRNA-related single-nucleotide polymorphisms (miRSNPs) and risk 18,174 cases 26,134 controls from 43 studies genotyped through...