A5005482775- Endometrial and Cervical Cancer Treatments
- Breast Cancer Treatment Studies
- Uterine Myomas and Treatments
- Ovarian cancer diagnosis and treatment
- HER2/EGFR in Cancer Research
- Endometriosis Research and Treatment
- Advanced Breast Cancer Therapies
- Cancer Cells and Metastasis
- Gynecological conditions and treatments
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- PARP inhibition in cancer therapy
- Cervical Cancer and HPV Research
- BRCA gene mutations in cancer
- Management of metastatic bone disease
- Breast Lesions and Carcinomas
- Ovarian function and disorders
- Reproductive System and Pregnancy
- Cancer Immunotherapy and Biomarkers
- Metastasis and carcinoma case studies
- Global Cancer Incidence and Screening
- Cell Adhesion Molecules Research
- Ultrasound Imaging and Elastography
- Reproductive Biology and Fertility
- Pelvic floor disorders treatments
University Medical Center Freiburg
2021-2024
University of Freiburg
2021-2024
Klinik für Frauenheilkunde
2011-2024
Institut für Frauengesundheit
2014-2021
Universitätsklinikum Tübingen
2011-2021
University of Tübingen
2011-2021
University Hospital of Zurich
2020
University Children's Hospital Tübingen
2013-2020
Weatherford College
2019
Universitäts Frauenklinik
2012-2015
Although unequivocal evidence has shown the prognostic relevance of circulating tumor cells (CTC) in peripheral blood patients with metastatic breast cancer, less is available for CTCs at time primary diagnosis.We conducted a pooled analysis individual data from 3,173 nonmetastatic (stage I-III) cancer five institutions. The prevalence and numbers were assessed diagnosis FDA-cleared CellSearch System (Janssen Diagnostics, LLC). Patient outcomes analyzed using meta-analytic procedures,...
Cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic patterns TILs by histotype and relation to other clinical factors.
Many women with ovarian endometrioid carcinoma present concurrent endometrial carcinoma. Organ-confined and low-grade synchronous tumors (SEOs) clinically behave as independent primary rather than a single advanced-stage We used 18 SEOs to investigate the ancestral relationship between components. Based on both targeted exome sequencing, 17 of patient cases simultaneous cancer endometrium ovary from our series showed evidence clonal relationship, ie, tumor metastasis. Eleven fulfilled...
Adenomyosis is an important clinical challenge in gynecology and healthcare economics; its fully developed form, hysterectomy often used to treat it premenopausal perimenopausal women. Symptoms of adenomyosis typically include menorrhagia, pelvic pain dysmenorrhea. Moreover, leiomyomas commonly coexist the same uterus, differentiating symptoms for each pathological process can be problematic. Although has been recognized over a century, reliable epidemiological studies on this condition are...
Background Mast cells (MCs) have long been suspected as important players for implantation based on the fact that their degranulation causes release of pivotal factors, e.g., histamine, MMPs, tryptase and VEGF, which are known to be involved in attachment posterior invasion embryo into uterus. Moreover, MC correlates with angiogenesis during pregnancy. The number MCs uterus has shown fluctuate menstrual cycle human estrus rat mouse indicating a hormonal influence recruitment from periphery...
Among patients with metastatic breast cancer (mBC), the frequency of germline mutations in susceptibility genes and clinical relevance these are unclear. In this study, a prospective cohort mBC was used to determine mutation rates for (BC) predisposition genes, evaluate characteristics mutations, assess influence on patient outcome.
Fifteen to thirty percent of all patients with metastatic breast cancer (MBC) develop brain metastases (BCBMs). Recently, the antibody-drug conjugates (ADCs) sacituzumab govitecan (SG) and trastuzumab deruxtecan (T-DXd) have shown be highly effective in treatment MBC. However, there are only limited data whether these macromolecules also BCBMs. We therefore aimed examine efficacy SG T-DXd stable active BCBMs a multicenter real-world analysis.
Abstract Objectives To compare women undergoing magnetic resonance‐guided focused ultrasound (MRgFUS) to a group of contemporaneously recruited total abdominal hysterectomy. Patient demographics, safety parameters, quality life outcomes and disability measures are reported. Methods One hundred nine were in seven centers for MRgFUS treatment 83 who underwent hysterectomy separate provide contemporaneous assessment safety. The adverse‐event profile parameters prospectively assessed. Patients...
Adenomyosis is rarely diagnosed before hysterectomy and commonly coexists with uterine leiomyomas. The objective of this study was to identify distinct features a concurrent diagnosis adenomyosis in women leiomyomas.We conducted case-control undergoing histologic both leiomyomas but no adenomyosis. A retrospective medical record review hospital ambulatory records performed ascertain sociodemographic anthropometric variables, as well confirm intraoperative pathologic findings.Our sample...
Recent publications have shown a negative influence of SLE on female ovarian reserve. Other authors not found significant impact Crohn's disease or early RA anti-Müllerian hormone (AMH) levels. This study aimed to investigate the potential effect Behçet's (BD), and SpA reserve as reflected by serum AMH levels.Serum samples from 33 RA, 32 30 BD patients without previous cytotoxic treatment were analysed compared with age-matched, healthy controls. was quantified using standard ELISA value 1-8...
Abstract We aimed to validate the prognostic association of p16 expression in ovarian high‐grade serous carcinomas (HGSC) and explore it other carcinoma histotypes. protein was assessed by clinical‐grade immunohistochemistry 6525 including 4334 HGSC using tissue microarrays from 24 studies participating Ovarian Tumor Tissue Analysis consortium. patterns were interpreted as abnormal (either overexpression referred block or absence) normal (heterogeneous). CDKN2A (which encodes p16) mRNA also...
In metastatic breast cancer (MBC), antigen profiles of tissue and primary tumor differ in up to 20 % patients. Reassessment predictive markers, including human epidermal growth factor receptor 2 (HER2) expression, might help optimize MBC treatment. While sampling is invasive often difficult repeat, circulating cell (CTC) analysis requires only a blood sample provide an easy-to-repeat, real-time “liquid biopsy” approach. The present retrospective study was conducted compare HER2 expression...
The telomerase reverse transcriptase (TERT) gene is highly expressed in stem cells and silenced upon differentiation. Cancer can attain immortality by activating TERT to maintain telomere length activity, which a crucial step of tumorigenesis. Two somatic mutations the promoter (C228T; C250T) have been identified as gain-of-function that promote transcriptional activation multiple cancers, such melanoma glioblastoma. A recent study investigating ovarian carcinomas found C228T C250T 15.9%...
PTEN loss is a putative driver in histotypes of ovarian cancer (high-grade serous (HGSOC), endometrioid (ENOC), clear cell (CCOC), mucinous (MOC), low-grade (LGSOC)). We aimed to characterise expression as biomarker epithelial large population-based study.
Abstract Objective To compare the mean hospital discharge times and perioperative outcomes for radiofrequency volumetric thermal ablation (RFVTA) of fibroids laparoscopic myomectomy (LM). Methods The present postmarket, randomized, prospective, single‐center, longitudinal, comparative study, conducted in Tübingen, Germany, evaluated RFVTA current standard care (LM) symptomatic uterine women who desired conservation. surgeons were blinded to treatment until all had been mapped by ultrasound....
The NATALEE study showed a significant benefit in invasive disease-free survival (iDFS) for patients with HR+/HER2− early breast cancer (eBC) at intermediate and high risk of recurrence who were treated the CDK4/6 inhibitor Ribociclib combination endocrine therapy (ET). This retrospective aims to apply inclusion criteria representative real-world cohort estimate proportion eligible adjuvant therapy. Patients underwent full surgical treatment eBC between January 2018 December 2020 two large...
Previous publications suggest a reduction in the ovarian reserve following surgery. The influence of underlying disease, histology, size cyst and type procedure remains unclear. aim this study was to investigate an operation on reserve, based anti-Müllerian hormone levels. values were determined by means standardized enzyme-linked immunosorbent assay. In total, 52 patients with one or more cysts different histologic entities treated at Department Women's Health University Hospital Tübingen...