A5074433394- Gynecological conditions and treatments
- Cellular Automata and Applications
- Cancer Cells and Metastasis
- Theoretical and Computational Physics
- Breast Cancer Treatment Studies
- Endometrial and Cervical Cancer Treatments
- Cancer Genomics and Diagnostics
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Stochastic processes and statistical mechanics
- HER2/EGFR in Cancer Research
- Ovarian cancer diagnosis and treatment
- Female Genital Mutilation/Cutting Issues
- Mathematical and Theoretical Epidemiology and Ecology Models
- Cancer survivorship and care
- Nonlinear Dynamics and Pattern Formation
- Reproductive System and Pregnancy
- Complex Systems and Time Series Analysis
- Sexual function and dysfunction studies
- Advanced Thermodynamics and Statistical Mechanics
- Cervical Cancer and HPV Research
- Statistical Mechanics and Entropy
- Genetics, Bioinformatics, and Biomedical Research
- Advanced MRI Techniques and Applications
- Cancer Immunotherapy and Biomarkers
University of Tübingen
2011-2024
Institut für Frauengesundheit
2016-2024
University Children's Hospital Tübingen
2013-2024
Universitäts Frauenklinik
2014-2024
Universitätsklinikum Tübingen
2016-2018
Institut für Medizinische Biometrie, Informatik und Epidemiologie
2008-2009
Heidelberg University
2000
Proteasomes are the main proteases responsible for cytosolic protein degradation and production of major histocompatibility complex class I ligands. Incorporation interferon γ–inducible subunits low molecular weight (LMP)-2, LMP-7, multicatalytic endopeptidase complex–like (MECL)-1 leads to formation immunoproteasomes which have been associated with more efficient antigen processing. Although differences in cleavage specificities constitutive observed frequently, motifs not described...
In metastatic breast cancer (MBC), antigen profiles of tissue and primary tumor differ in up to 20 % patients. Reassessment predictive markers, including human epidermal growth factor receptor 2 (HER2) expression, might help optimize MBC treatment. While sampling is invasive often difficult repeat, circulating cell (CTC) analysis requires only a blood sample provide an easy-to-repeat, real-time “liquid biopsy” approach. The present retrospective study was conducted compare HER2 expression...
To prospectively assess circulating tumor cell (CTC) status at baseline (CTCBL) and after one cycle of a new line systemic therapy (CTC1C), changes from CTCBL to CTC1C (CTC kinetics, CTCKIN) for their utility in predicting response, progression-free (PFS) overall survival (OS) metastatic breast cancer (MBC). was determined as negative (-) or positive (+) < 5 ≥ CTCs/7.5 ml blood using CellSearch™ (Veridex). CTCKIN categorized favorable (CTC1C-) unfavorable (CTC1C+). Tumor response be assessed...
The Mayer–Rokitansky–Küster–Hauser syndrome is characterized by aplasia of the uterus and upper two-thirds vagina. While it can appear as an isolated genital malformation, often associated with extragenital abnormalities, little still known about pathogenetic background. To provide overview malformations syndromes well to examine possible ties between rudimentary tissue patient characteristics, we analyzed a cohort 469 patients MRKHS 298 uterine rudiments removed during surgery. A total 165...
Abstract The main part of cytosolic protein degradation depends on the ubiquitin-proteasome system. Proteasomes degrade their substrates into small peptide fragments, some which are translocated endoplasmatic reticulum and loaded onto MHC class I molecules, then transported to cell surface for inspection by CTL. A reliable prediction proteasomal cleavages in a given identification CTL epitopes would benefit immensely from additional cleavage data training algorithms. To increase knowledge...
Cervical cancer represents the fourth leading cause of among women and is associated with over 311,000 annual deaths worldwide. Timely diagnosis crucial given lengthy pre-cancerous phase, which typified by cervical intraepithelial neoplastic lesions. However, current treatment methods are often tissue-destructive can be accompanied severe side effects. To address these concerns, our study introduces a novel, gentle approach for tissue-preserving CIN lesions.We present findings controlled,...
In cancer patients, the pathology report serves as an important basis for treatment. Therefore, a correct diagnosis is crucial, and diagnostic discrepancies may be of clinical relevance. It was aim this study to perform specialized histopathology review investigate potential implications expert second opinion in endometrial cancer.Patients treated carcinoma at Tübingen University Women's hospital between 2003 2013 were identified. Original reports reviewed, contributing pathologists asked...
We undertook to study possible determinants of female sexual dysfunction (FSD) in a large cohort medical students from German-speaking countries.We conducted an online questionnaire-based anonymous survey >2600 enrolled at universities. The questionnaire comprised the Female Sexual Function Index (FSFI) plus additional questions regarding contraception, activity, age, height, weight, lifestyle, activity work, sexuality and emotional interaction with steady partner, pregnancy history plans,...
Background/Aims: Uterine rudiments from patients with Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) contain all tissues typically found in the uterus. Endometrium predominantly exhibits basalis-like features, and endometrial proliferative capacity patients’ epithelium stroma is significantly lower. Methods: This single-center, prospective study conducted at a major German university hospital compared in-vitro decidualization cultured ESCs MRKHS hysterectomy controls. Primary ESC cultures...