A5075656855- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Breast Lesions and Carcinomas
- Ultrasound Imaging and Elastography
- HER2/EGFR in Cancer Research
- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related Molecular Pathways
- Medical and Health Sciences Research
- Ultrasound and Hyperthermia Applications
- Breast Implant and Reconstruction
- Mobile Health and mHealth Applications
- Metabolomics and Mass Spectrometry Studies
- Health and Medical Studies
- Cancer Treatment and Pharmacology
- Photoacoustic and Ultrasonic Imaging
- Epigenetics and DNA Methylation
- Medical History and Research
- MRI in cancer diagnosis
- Healthcare Systems and Technology
- Colorectal Cancer Treatments and Studies
- Lung Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Advanced Breast Cancer Therapies
Heidelberg University
2015-2025
University Hospital Heidelberg
2014-2024
Frauenklinik Heidelberg
2014-2023
Universitäts Frauenklinik
2014-2022
National Center for Tumor Diseases
2014-2018
Metastasis is the principal cause of high morbidity and mortality among breast cancer (BC) patients. Identification markers that can be routinely monitored to predict onset metastasis in BC patients prognosis metastatic (MBC) would increase their median survival. In this study, plasma miRNAs 40 MBC were profiled by TaqMan low density arrays with prognostic capacity identified. The candidates validated initially samples 237 subsequently 335 from an independent study cohort Sixteen established...
In metastatic breast cancer (MBC), antigen profiles of tissue and primary tumor differ in up to 20 % patients. Reassessment predictive markers, including human epidermal growth factor receptor 2 (HER2) expression, might help optimize MBC treatment. While sampling is invasive often difficult repeat, circulating cell (CTC) analysis requires only a blood sample provide an easy-to-repeat, real-time “liquid biopsy” approach. The present retrospective study was conducted compare HER2 expression...
To prospectively assess circulating tumor cell (CTC) status at baseline (CTCBL) and after one cycle of a new line systemic therapy (CTC1C), changes from CTCBL to CTC1C (CTC kinetics, CTCKIN) for their utility in predicting response, progression-free (PFS) overall survival (OS) metastatic breast cancer (MBC). was determined as negative (-) or positive (+) < 5 ≥ CTCs/7.5 ml blood using CellSearch™ (Veridex). CTCKIN categorized favorable (CTC1C-) unfavorable (CTC1C+). Tumor response be assessed...
Abstract Li-Fraumeni syndrome is a cancer predisposition caused by pathogenic TP53 germline variants and associated with high lifelong risk. We analysed the German LFS registry that contains data on 304 individuals. Cancer phenotypes were correlated grouped according to their ability transactivate target genes in yeast assay using traditional (non-functional, partially-functional) novel (clusters A, B, C) classification of into different groups. Partially-functional cluster B or C enriched...
In recent years, metabolites have attracted substantial attention as promising novel biomarkers of various diseases. However, breast cancer plasma metabolite studies are still in their infancy. Here, we investigated the potential to serve minimally invasive, early detection markers primary cancer. We profiled extracted from patients and healthy controls using tandem mass spectrometry (UHPLC‐MS/MS FIA‐MS/MS). Two were found be upregulated, while 16 downregulated compared both training...
Abstract Background The estrogen receptor (ER), progesterone (PR), and human epidermal growth factor 2 (HER2) statuses are frequently discordant between the primary tumor metastatic lesions in breast cancer. This can have important therapeutic implications. Patients methods In all, 541 patients with available from both lesion treated at Heidelberg Tuebingen University Hospitals 1982 2018 were included. Results Statistically significant discordance rates of 14% 32% found for ER PR. HER2...
The demand for fetal monitoring and constant reassurance is high in pregnant women. Consequently, women use various health apps are more likely to visit emergency departments due subjective but nonurgent complaints. However, electronic (eHealth) mobile (mHealth) solutions rarely used prevent consultations. To implement modern care solutions, a better understanding of the attitudes, fears, hopes professionals toward eHealth mHealth needed.The aim this study was investigate attitudes...
Conventional tumor markers have limited value for prognostication and treatment monitoring in metastatic breast cancer (MBC) patients novel circulating therefore need to be explored. Hyaluronic acid (HA) is a major macropolysaccharide the extracellular matrix reported associated with progression. In our study, we investigated plasma HA level respect progression free survival (PFS) overall (OS), as well MBC patients. The prognostic of was discovery cohort 212 2.5-year follow-up validated an...
Abstract Purpose As an independent, negative-prognostic biomarker for progression-free survival (PFS) and overall (OS), circulating tumor cells (CTCs) constitute a promising component developing liquid biopsy patients with metastatic breast cancer (MBC). The effects of HER2-targeted therapy such as trastuzumab, pertuzumab, T-DM1, lapatinib on CTC status longitudinal enumeration were assessed in this trial. Methods 264 MBC was analyzed prior to after 4 weeks new line palliative systemic...
Abstract Objectives AI-based algorithms for medical image analysis showed comparable performance to human readers. However, in practice, diagnoses are made using multiple imaging modalities alongside other data sources. We determined the importance of this multi-modal information and compared diagnostic routine breast cancer diagnosis ultrasound interpretations by humans or algorithms. Methods Patients were recruited as part a multicenter trial (NCT02638935). The enrolled 1288 women...
Abstract Li‐Fraumeni syndrome (LFS) is a rare autosomal dominant cancer predisposition associated with highly elevated lifetime risk. This and the recommended intense surveillance program represent large psychological burden on families. In order to develop targeted psychosocial interventions, we conducted needs assessment. Adults (≥18 years) LFS were included via regular hospital visits online support groups newsletters. Individuals filled out questionnaire addressing among others: fear of...
Preoperative evaluation of axillary lymph node status is crucial for the selection both systemic and surgical treatment in early breast cancer. This study assessed particular role additional shear wave elastography (SWE) staging patients undergoing initial cancer diagnostics.
Abstract Objectives Response assessment to neoadjuvant systemic treatment (NAST) guide individualized in breast cancer is a clinical research priority. We aimed develop an intelligent algorithm using multi-modal pretreatment ultrasound and tomosynthesis radiomics features addition variables predict pathologic complete response (pCR) prior the initiation of therapy. Methods used retrospective data on patients who underwent before starting NAST. developed support vector machine patient tumor...
Background: Pregnancy can be distressing, particularly if expectant mothers are worried about the well-being of their fetus.Consequently, desire for reassurance and frequent fetal monitoring is often pronounced.Smart wearable devices telemedicine promising tools that could assist women in self-monitoring pregnancy at home, hence disburdening emergency departments (EDs).They present possibility to clarify need urgent care remotely offer tighter monitoring.However, patients' acceptance such...
The Histolog® Scanner (SamanTree Medical SA, Lausanne, Switzerland) is a large field-of-view confocal laser scanning microscope designed to allow intraoperative margin assessment by the production of histological images ready for in operating room. We evaluated feasibility and performance (HS) correctly identify infiltrated margins clinical practice lumpectomy specimens. It was extrapolated if utilization HS has potential reduce therefore re-operation rates patients undergoing breast...
Machine learning with radiomics showed great potential to predict response neoadjuvant systemic treatment (NAST) for breast cancer. However, performance across different ethnicities and racial bias remain unclear. We aimed develop an intelligent algorithm using pretreatment MRI in addition clinical variables, validate their ethnically diverse populations. used institutional data of patients who underwent before NAST. developed a support vector machine based on German features patient tumor...
Objectives Patients with triple‐negative breast cancer (TNBC) exhibit a fast tumor growth rate and poor survival outcomes. In this study, we aimed to develop compare intelligent algorithms using ultrasound radiomics features in addition clinical variables identify patients TNBC prior histopathologic diagnosis. Methods We used single‐center, retrospective data of who underwent before verification subsequent neoadjuvant systemic treatment (NAST). developed logistic regression an elastic net...
Abstract Objective The FUSION-X-US-II prototype was developed to combine 3D automated breast ultrasound (ABUS) and digital tomosynthesis in a single device. We evaluated the performance of ABUS examination clinical setting. Methods In this prospective feasibility study, were performed using without any change position patients referred for clarification lesions with an indication tomosynthesis. images interpreted independently from standard by diagnostics specialist. Any detected lesion...