A5073661795- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Cancer survivorship and care
- Breast Lesions and Carcinomas
- Pancreatic and Hepatic Oncology Research
- Cancer Treatment and Pharmacology
- Pancreatitis Pathology and Treatment
- Maternal Mental Health During Pregnancy and Postpartum
- Aortic Disease and Treatment Approaches
- Cancer Cells and Metastasis
- Cardiac, Anesthesia and Surgical Outcomes
- Gallbladder and Bile Duct Disorders
- Economic and Financial Impacts of Cancer
- Gastric Cancer Management and Outcomes
- Workplace Health and Well-being
- Colorectal Cancer Treatments and Studies
- Mental Health Treatment and Access
- Chemotherapy-related skin toxicity
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Genomics and Diagnostics
- Hip and Femur Fractures
- Cardiac Valve Diseases and Treatments
- Advanced Breast Cancer Therapies
- Organ Transplantation Techniques and Outcomes
- Maternal and Perinatal Health Interventions
Heidelberg University
2017-2025
Zimmer Biomet (Germany)
2017-2025
University Hospital Heidelberg
2017-2024
Institut für Medizinische Biometrie, Informatik und Epidemiologie
2017-2024
Heidelberg University
2024
Zimmer Biomet (Netherlands)
2023-2024
Heidelberg University of Education
2024
University of Potsdam
2023-2024
University Hospital Ulm
2023
Erasmus University Rotterdam
2023
Abstract OBJECTIVES The goal was to develop a scoring system predict the 30-day mortality rate for patients undergoing surgery acute type A aortic dissection on basis of German Registry Acute Type Aortic Dissection (GERAADA) data set and provide Web-based application standard use. METHODS total 2537 enrolled in GERAADA who underwent between 2006 2015 were analysed. Variable selection performed using R-package FAMoS. robustness results confirmed via bootstrap procedure. coefficients final...
To investigate the perioperative and oncologic long-term outcomes of patients with LAPC after surgical resection at a high-volume center for pancreatic surgery.The role surgery in arterial involvement is controversial.We analyzed 385 consecutive undergoing PAR (n = 195) or PAD 190) encased artery between January 1, 2003 April 30, 2019.There were 183 total pancreatectomies, 113 partial pancreatoduodenectomies, 79 distal 10 resections tumor recurrences, including 121 multivisceral 171 venous...
Chemotherapy is established as primary treatment in patients with stage IV colorectal cancer and unresectable metastases. Data from nonrandomized clinical trials have fueled persistent uncertainty if tumor resection (PTR) before chemotherapy prolongs survival. We investigated the prognostic value of PTR newly diagnosed colon who were not amenable to curative treatment.
Patient Reported Outcomes (PRO) are gaining more and importance in the context of clinical trials. The assessment PRO is frequently performed by questionnaires where multiple items a questionnaire usually pooled within summarizing scores. These scores used as variables to measure subjective aspects treatments diseases. In research, calculation these mostly kept very simple, e.g. simple summation item values. medical literature, there hardly any guidance for performing refinements deducing...
Due to the intense crosstalk between coagulation and immune systems, disorders are an integral part of disturbed host response infection that defines sepsis. These so-called sepsis-induced coagulopathies (SIC) associated with increased morbidity mortality. However, we still do not know enough about prevalence risk factors for SIC in different patient groups. In this study, present a secondary analysis prospective, observational study. The objectives were (1) estimate at onset sepsis, (2)...
Background: Breast cancer represents the most common malignant disease in women worldwide. As currently systematic palliative treatment only has a limited effect on survival rates, concept of health-related quality life (HRQoL) is gaining more and importance therapy setting metastatic breast cancer. One major patient-reported outcomes (PROs) for measuring HRQoL patients with provided by European Organization Research Treatment Cancer (EORTC). Currently, paper-based surveys still predominate,...
LBA3507 Background: Systemic chemotherapy improves survival of patients with stage IV colon cancer who are no candidates for curative therapy. However, it has remained controversial, if primary tumor resection prior to further prolongs these patients. We report the combined results SYNCHRONOUS and CCRe-IV trial, comparing followed by systemic alone in Methods: The trial (ISRCTN30964555) is a multicentre, randomized, controlled, superiority two-group parallel design. Colon synchronous...
Current clinical guidelines recommend antifibrinolytic treatment for liver transplantation to reduce blood loss and transfusion utilization. However, the relevance of fibrinolysis during is questionable, a benefit tranexamic acid (TXA) in this context not supported by sufficient evidence, adverse effects are also conceivable. Therefore, we tested hypothesis that use TXA associated with reduced loss.
Chemotherapy-induced peripheral neuropathy (CIPN) is a common, dose-limiting adverse effect of taxane-based chemotherapies. Currently, there no established strategy for prevention or treatment. To compare the effectiveness 1-sided hand cooling and compression preventing CIPN in patients with primary breast cancer receiving chemotherapy. The POLAR randomized clinical trial was conducted at National Center Tumor Diseases Heidelberg between November 2019 January 2022. Female who received weekly...
BackgroundAxillary ultrasound (AUS) is a standard procedure in the preoperative clinical identification of axillary metastatic lymph node (LN) involvement. It guides decisions about local and systemic therapy for patients with early breast cancer (EBC). But there only weak evidence on diagnostic criteria interpretation. The aim this study was to assess performance AUS detection exclusion LN metastases.MethodsIn retrospective single-center study, 611 consecutive EBC 622 axillae underwent +/-...
The most frequent malignant disease in women is breast cancer. In the metastatic setting, quality of life primary therapeutic goal, and systematic treatment has only a limited effect on survival rates; therefore, concept health-related (HRQoL) measurement patient-reported outcomes (PROs) are gaining more importance therapy setting diseases such as One frequently used questionnaires for measuring HRQoL patients with cancer Functional Assessment Cancer Therapy-Breast (FACT-B). Currently,...
Abstract Purpose As an independent, negative-prognostic biomarker for progression-free survival (PFS) and overall (OS), circulating tumor cells (CTCs) constitute a promising component developing liquid biopsy patients with metastatic breast cancer (MBC). The effects of HER2-targeted therapy such as trastuzumab, pertuzumab, T-DM1, lapatinib on CTC status longitudinal enumeration were assessed in this trial. Methods 264 MBC was analyzed prior to after 4 weeks new line palliative systemic...
Background Pregnant women are increasingly using mobile apps to access health information during the antenatal period. Therefore, digital solutions can potentially be used as monitoring instruments pregnancy. However, a main factor of success is high user engagement. Objective The aim this study was analyze engagement and factors influencing compliance in longitudinal targeting pregnant app with self-tracking. Methods Digitally collected data concerning demographics, medical history,...
Poor patient-reported satisfaction after breast-conserving therapy (BCT) has been associated with impaired health-related quality of life (HRQOL) and subsequent depression in retrospective analysis. This prospective cohort study aimed to assess the HRQOL patients who have undergone BCT using BREAST-Q, identify clinical risk factors for lower patient satisfaction.Patients primary breast cancer undergoing were asked complete BREAST-Q preoperatively (T1) baseline evaluation, then 3 4 weeks...
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) insufficiency and lipopolysaccharide-responsive beige-like anchor (LRBA) deficiency are both complex immune dysregulation syndromes with an underlying regulatory T cell dysfunction due to the lack of CTLA-4 protein. As anticipated, clinical phenotypes LRBA similar. Main manifestations include hypogammaglobulinemia, lymphoproliferation, autoimmune cytopenia, immune-mediated respiratory, gastrointestinal, neurological, skin involvement,...
Today, the decision to treat patients with chemotherapy for early breast cancer (EBC) is made based on patient's individual risk stratification and tumor biology. In cases indication, neoadjuvant application (NACT) preferred option in comparison primary surgery adjuvant (ACT). Age remains a relevant factor decision-making process. The aim of present study was illustrate impact age use systemic therapy clinical routine.The separately analyzed among six cohorts EBC who had been treated at 104...
To determine perioperative and oncologic outcomes after distal pancreatectomy with en bloc resection of the celiac axis (DP-CAR).DP-CAR can be used in a selective group patients to resect locally advanced pancreatic cancer involving or common hepatic artery without arterial reconstruction by preserving retrograde blood flow via gastroduodenal liver stomach.We analyzed all consecutive who had undergone DP-CAR between May 2003 April 2022 at tertiary hospital specialized surgery present one...
Abstract OBJECTIVES Several short-term analyses from German Registry for Acute Aortic Dissection Type A (GERAADA) have been published. This study investigated whether risk factors are transferable to the long-term prognosis of patients. METHODS Thirty-three centres with 2686 patients participated in follow-up. total 1164 died, 1063 survived and 459 were lost follow-up during timeframe (mean duration: 10.2 years). Long-term mortality cohort was compared an age-stratified, population. RESULTS...
Preoperative evaluation of axillary lymph node status is crucial for the selection both systemic and surgical treatment in early breast cancer. This study assessed particular role additional shear wave elastography (SWE) staging patients undergoing initial cancer diagnostics.