A5084110893- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Cardiac and Coronary Surgery Techniques
- Anesthesia and Pain Management
- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Intensive Care Unit Cognitive Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Organ Transplantation Techniques and Outcomes
- Cardiac Arrest and Resuscitation
- Aortic aneurysm repair treatments
- Hip and Femur Fractures
- Anesthesia and Sedative Agents
- Mechanical Circulatory Support Devices
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Sphingolipid Metabolism and Signaling
- Biosensors and Analytical Detection
- Cancer, Stress, Anesthesia, and Immune Response
- Lipoproteins and Cardiovascular Health
- SARS-CoV-2 detection and testing
- Pain Management and Opioid Use
- Advanced biosensing and bioanalysis techniques
University Hospital Heidelberg
2015-2025
Heidelberg University
2015-2025
RWTH Aachen University
2025
Amsterdam University Medical Centers
2025
University of Amsterdam
2025
University Hospital Bonn
2025
Universitätsklinikum Würzburg
2025
University of Ferrara
2024
Iuliu Hațieganu University of Medicine and Pharmacy
2024
Jagiellonian University
2024
Background— All treatments of acute myocardial infarction are aimed at rapid revascularization the occluded vessel; however, no clinical strategies currently available to protect heart from ischemia/reperfusion injury after restitution blood flow. We hypothesized that some cholesterol transport–independent biological properties high-density lipoprotein (HDL) implied in atheroprotection may also be beneficial settings reperfusion injury. Methods and Results— In an vivo mouse model...
ABSTRACT Background SARS-CoV-2 antigen rapid diagnostic tests (Ag-RDTs) are increasingly being integrated in testing strategies around the world. Studies of Ag-RDTs have shown variable performance. In this systematic review and meta-analysis, we assessed clinical accuracy (sensitivity specificity) commercially available Ag-RDTs. Methods Results We registered on PROSPERO (Registration number: CRD42020225140). systematically searched multiple databases (PubMed, Web Science Core Collection,...
Background: The invisible fluid leaking from a partially resected pancreas is associated with complications including postoperative pancreatic fistula (POPF), calling for strategies to visualize intraoperative leakage. This single-arm, monocentric trial aims evaluate the usefulness and safety of SmartPAN, hydrogel that reacts alkali fluids by changing color thus enables surgeon take immediate action close Methods: Patients awaiting partial resection any indication were recruited receive...
Myocardial infarction after major surgery is frequent, drives outcome, and consumes health resources. Specific prediction detection of perioperative myocardial an unmet clinical need. With the widespread use high-sensitive cardiac troponin T assays, positive tests become but their diagnostic or prognostic impact arguable. We, therefore, studied association routinely determined pre- postoperative with occurrence adverse events.This study was a prospective non-interventional trial.This...
Abstract Background Preoperative risk prediction in patients at elevated cardiovascular shows limited accuracy. Platelet to lymphocyte ratio (PLR) and neutrophil (NLR) indicate systemic inflammation. Both have been investigated for outcome the field of oncology medicine, as well adverse events non-surgical increased risk. Methods For this post-hoc analysis, we included all 38 coronary heart disease from Leukocytes Cardiovascular Perioperative Events cohort-1 study scheduled elective...
<h3>Importance</h3> Morbidity is still high in pancreatic surgery, driven mainly by gastrointestinal complications such as fistula. Perioperative thoracic epidural analgesia (EDA) and patient-controlled intravenous (PCIA) are frequently used for pain control after surgery. Evidence from a post hoc analysis suggests that PCIA associated with fewer complications. <h3>Objective</h3> To determine whether postoperative decreases the occurrence of surgery compared EDA. <h3>Design, Setting,...
Intraoperative handovers of anesthesia care are common. Handovers might improve by reducing physician fatigue, but there is also an inherent risk losing critical information. Large observational analyses report associations between handover and adverse events, including higher mortality.To determine the effect on postoperative morbidity mortality.This was a parallel-group, randomized clinical trial conducted in 12 German centers with patients enrolled June 2019 2021 (final follow-up, July...
Introduction Previous studies demonstrated that the implementation of Kidney Disease Improving Global Outcomes (KDIGO) guideline-based bundle, consisting different supportive measures in patients at high risk for acute kidney injury (AKI), might reduce rate and severity AKI after surgery. However, effects care bundle broader population undergoing surgery require confirmation. Methods analysis The BigpAK-2 trial is an international, randomised, controlled, multicentre trial. aims to enrol...
Current clinical guidelines recommend antifibrinolytic treatment for liver transplantation to reduce blood loss and transfusion utilization. However, the relevance of fibrinolysis during is questionable, a benefit tranexamic acid (TXA) in this context not supported by sufficient evidence, adverse effects are also conceivable. Therefore, we tested hypothesis that use TXA associated with reduced loss.
Higher levels of carbon dioxide (CO
Taking the best possible care of our patients has been main driver to constantly develop specialty and pushing boundaries what 50, 20 or 10 years ago was beyond imagination. Clinical research paved way for these improvements. Large international observational multicentre studies randomised controlled trials have enabled translation promising findings into improved patient care. However, serious challenges are piling up on horizon. Europe is facing a dramatic healthcare workforce crisis.1 The...
The main risk factor for developing transplant vasculopathy (TV) after solid organ transplantation is de-novo production of donor-specific antibodies (DSAs) binding to endothelial cells (ECs) within the graft’s vasculature. Diverse leukocyte populations recruited into vessel wall via activated ECs contribute vascular inflammation. Subsequent smooth muscle cell proliferation results in intima hyperplasia, pathophysiological correlate TV. We demonstrated that incubating aortic EC with...
Thrombomodulin (TM), via its lectin-like domain (LLD), exhibits anti-inflammatory properties partly by sequestering the pro-inflammatory cytokine, high-mobility group box 1 (HMGB1). Since myocardial damage after ischaemia and reperfusion is mediated inflammation, we evaluated cardioprotective effects of LLD TM. Using an in vivo mouse model transient vitro models cardiomyocyte hypoxia, assessed ability to suppress HMGB1-mediated activation receptors, receptor for advanced glycation...
Myocardial infarction (MI) results in acute impairment of left ventricular (LV) function through the initial development cardiomyocyte death and subsequent progression LV remodelling. The expression syndecan-4 (Sdc4), a transmembrane proteoglycan, is up-regulated after MI, but its heart remains unknown. Here, we characterize effects Sdc4 deficiency murine myocardial ischaemia permanent infarction. Targeted deletion (Sdc4–/–) leads to increased damage ischaemic–reperfusion injury due enhanced...
Vascular calcification is a severe consequence of several pathological processes with lack effective therapy. Recent studies suggest that circulating and resident mesenchymal stem cells (MSC) contribute to the osteogenic program vascular calcification. Molecular mechanisms underlying MSC potential differentiation remain, however, sparsely explored. We investigated role for complement receptor C5aR in these processes. found expression was upregulated upon human osteoblasts. inhibition by...
Importance Nearly 16 million surgical procedures are conducted in North America yearly, and postoperative cardiovascular events frequent. Guidelines suggest functional capacity or B-type natriuretic peptides (BNP) to guide perioperative management. Data comparing the performance of these approaches scarce. Objective To compare addition either N-terminal pro-BNP (NT-proBNP) self-reported clinical scores estimate risk major adverse cardiac (MACE). Design, Setting, Participants This cohort...
The American Heart Association (AHA) recently defined the cardiovascular-kidney-metabolic syndrome (CKM) as a new entity to address complex interactions between heart, kidneys, and metabolism. aim of this study was assess outcome impact CKM in patients undergoing noncardiac surgery.