Melanie Meersch
A5101532663- Acute Kidney Injury Research
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Muscle and Compartmental Disorders
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- Dialysis and Renal Disease Management
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Heart Failure Treatment and Management
- SARS-CoV-2 and COVID-19 Research
- Renal function and acid-base balance
- Traumatic Brain Injury and Neurovascular Disturbances
- Chronic Kidney Disease and Diabetes
- Intensive Care Unit Cognitive Disorders
- GDF15 and Related Biomarkers
- Alkaline Phosphatase Research Studies
- Neonatal and Maternal Infections
- Vitamin C and Antioxidants Research
- Metabolism and Genetic Disorders
- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Atrial Fibrillation Management and Outcomes
- Heparin-Induced Thrombocytopenia and Thrombosis
University of Münster
2025
University Hospital Münster
2020-2024
The incidence, patient features, risk factors and outcomes of surgery-associated postoperative acute kidney injury (PO-AKI) across different countries health care systems is unclear. We conducted an international prospective, observational, multi-center study in 30 patients undergoing major surgery (> 2-h duration intensive unit (ICU) or high dependency admission). primary endpoint was the occurrence PO-AKI within 72 h defined by Kidney Disease: Improving Global Outcomes (KDIGO) criteria....
Ilofotase alfa is a human recombinant alkaline phosphatase with reno-protective effects that showed improved survival and reduced Major Adverse Kidney Events by 90 days (MAKE90) in sepsis-associated acute kidney injury (SA-AKI) patients. REVIVAL, was phase-3 trial conducted to confirm its efficacy safety. In this international double-blinded randomized-controlled trial, SA-AKI patients were enrolled < 72 h on vasopressor 24 of AKI. The primary endpoint 28-day all-cause mortality. main...
Vasoplegia is common after cardiac surgery, associated with hyperreninemia, and can lead to acute kidney stress. We aimed conduct a pilot study test the hypothesis that, in vasoplegic surgery patients, angiotensin-II (AT-II) may not increase stress (measured by [TIMP-2]*[IGFBP7]).
Novel interventions for the prevention or treatment of acute kidney injury (AKI) are currently lacking. To facilitate evaluation and adoption new treatments, use most appropriate design endpoints clinical trials in AKI is critical yet there little consensus regarding these issues. We aimed to develop recommendations on trial studies based existing data expert consensus. At 31st Acute Disease Quality Initiative (ADQI) meeting, international experts care, nephrology, involving adults...
Introduction Previous studies demonstrated that the implementation of Kidney Disease Improving Global Outcomes (KDIGO) guideline-based bundle, consisting different supportive measures in patients at high risk for acute kidney injury (AKI), might reduce rate and severity AKI after surgery. However, effects care bundle broader population undergoing surgery require confirmation. Methods analysis The BigpAK-2 trial is an international, randomised, controlled, multicentre trial. aims to enrol...
Abstract Purpose There is evidence that lower activity of the RAF/MEK/ERK network associated with positive outcomes in mild and moderate courses COVID-19. The effect this cascade COVID-19 sepsis still undetermined. Therefore, we tested hypothesis COVID-19-induced an impact on 30-day survival. Methods We used biomaterial from 81 prospectively recruited patients multicentric CovidDataNet.NRW-study cohort (German clinical trial registry: DRKS00026184) their collected medical history, vital...
Abstract Rationale Steroid profiles in combination with a corticotropin stimulation test provide information about steroidogenesis and its functional reserves critically ill patients. Objectives We investigated whether steroid before after can predict the risk of in-hospital death sepsis. Methods An exploratory data analysis double blind, randomized trial sepsis (HYPRESS [HYdrocortisone for PRevention Septic Shock]) was performed. The included adult patients who were not shock randomly...
Sepsis remains the leading cause of mortality in critically ill patients, and is increased when acute kidney injury (AKI) occurs. The Kidney Disease: Improving Global Outcomes (KDIGO) guideline recommends implementation supportive measures patients at high risk for AKI. However, it unclear to what extent these nephroprotective are implemented daily clinical practice especially those with high-risk exposures such as sepsis.We analyzed Medical Information Mart Intensive Care IV (MIMIC-IV)...
Introduction More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and associated with adverse short-term long-term outcomes. However, there large variation in the incidence of reported AKI rates. The establishment an accurate epidemiology surgery-associated important for healthcare policy, quality initiatives, clinical trials, as well improving guidelines. objective Epidemiology Surgery-associated Kidney...
Abstract Purpose: Ilofotase alfa is a human recombinant alkaline phosphatase with reno-protective effects that showed improved survival and reduced MAKE90 in sepsis-associated acute kidney injury (SA-AKI) patients. ‘ REVIVAL’, was aphase 3 trial, conducted to confirm its efficacy safety. Methods: In this international double-blinded randomized-controlled SA-AKI patients were enrolled <72 hours on vasopressor <24 of AKI. The primary endpoint 28-day all-cause mortality. key secondary...
GDF-15 prevents ventilator-induced lung injury by inhibiting the formation of platelet-neutrophil aggregates -
Ischemia-reperfusion injury is a major cause of acute kidney injury. Many cytokines are involved in the pathogenesis renal ischemia-reperfusion IL24 member IL10 family and has gained importance because its apoptosis-inducing effects tumor disease besides immunoregulative function. Littles known about role disease. Using mouse model, we found that upregulated after tubular epithelial cells infiltrating inflammatory source IL24. Mice lacking protected from inflammation. Cell culture studies...
This article describes the statistical analysis plan for Biomarker-guided intervention to prevent AKI after major surgery (BigpAK-2) trial.
Acute kidney injury (AKI) is a frequent complication in critically ill patients. Supportive treatment of AKI patients based on renal-replacement therapy, including continuous veno-venous hemofiltration (CVVH). To limit clotting events extracorporeal surfaces, anticoagulants are administered, systemic heparin and local citrate. The differential comparative effects these leukocyte function acute are, so far, insufficiently understood. In this bio-add-on-study, were randomized as part...