Morten H. Bestle
A5054243473- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- COVID-19 Clinical Research Studies
- Acute Kidney Injury Research
- Electrolyte and hormonal disorders
- Long-Term Effects of COVID-19
- Renal function and acid-base balance
- Nosocomial Infections in ICU
- Thermal Regulation in Medicine
- Cardiac, Anesthesia and Surgical Outcomes
- Family and Patient Care in Intensive Care Units
- Anesthesia and Neurotoxicity Research
- Muscle and Compartmental Disorders
- Anesthesia and Sedative Agents
- Pneumonia and Respiratory Infections
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Emergency and Acute Care Studies
- Blood transfusion and management
- Platelet Disorders and Treatments
- Health, psychology, and well-being
- Thermoregulation and physiological responses
University of Copenhagen
2016-2025
Zealand University Hospital
2013-2025
Copenhagen University Hospital
2012-2025
Centre for Research in Intensive Care
2019-2024
Rigshospitalet
2012-2024
Nordsjællands Hospital
2014-2023
Glostrup Hospital
2019-2023
Peking University People's Hospital
2023
Peking University
2023
Stavanger University Hospital
2022
Hydroxyethyl starch (HES) [corrected] is widely used for fluid resuscitation in intensive care units (ICUs), but its safety and efficacy have not been established patients with severe sepsis.In this multicenter, parallel-group, blinded trial, we randomly assigned sepsis to the ICU either 6% HES 130/0.42 (Tetraspan) or Ringer's acetate at a dose of up 33 ml per kilogram ideal body weight day. The primary outcome measure was death end-stage kidney failure (dependence on dialysis) 90 days after...
<h3>Abstract</h3> Micro-CT is a powerful tool to analyze and visualize the internal morphology of human permanent teeth. It increasingly used for investigation epidemiological questions provide dentist with necessary information required successful endodontic treatment. The aim present paper was propose an image processing method automate parts work needed fully describe One hundred four teeth were scanned on high-resolution micro-CT using automatic specimen changer. Python code in Jupyter...
For patients in intensive care units, sepsis is a common and potentially deadly complication prompt initiation of appropriate antimicrobial therapy improves prognosis. The objective this trial was to determine whether strategy spectrum escalation, guided by daily measurements the biomarker procalcitonin, could reduce time therapy, thus improving survival.Randomized controlled open-label trial.Nine multidisciplinary units across Denmark.A total 1,200 critically ill were included after meeting...
Prophylaxis for gastrointestinal stress ulceration is frequently given to patients in the intensive care unit (ICU), but its risks and benefits are unclear.In this European, multicenter, parallel-group, blinded trial, we randomly assigned adults who had been admitted ICU an acute condition (i.e., unplanned admission) were at risk bleeding receive 40 mg of intravenous pantoprazole (a proton-pump inhibitor) or placebo daily during stay. The primary outcome was death by 90 days after...
Patients with acute hypoxemic respiratory failure in the intensive care unit (ICU) are treated supplemental oxygen, but benefits and harms of different oxygenation targets unclear. We hypothesized that using a lower target for partial pressure arterial oxygen (Pao2) would result mortality than higher target.
Intravenous fluids are recommended for the treatment of patients who in septic shock, but higher fluid volumes have been associated with harm intensive care unit (ICU).In this international, randomized trial, we assigned shock ICU had received at least 1 liter intravenous to receive restricted or standard therapy; were included if onset within 12 hours before screening. The primary outcome was death from any cause 90 days after randomization.We enrolled 1554 patients; 770 restrictive-fluid...
We compared dexamethasone 12 versus 6 mg daily for up to 10 days in patients with coronavirus disease 2019 (COVID-19) and severe hypoxaemia the international, randomised, blinded COVID STEROID 2 trial. In primary, conventional analyses, predefined statistical significance thresholds were not reached. conducted a pre-planned Bayesian analysis facilitate probabilistic interpretation. analysed outcome data within 90 intention-to-treat population (data available 967 982 patients) using models...
Haloperidol is frequently used to treat delirium in patients the intensive care unit (ICU), but evidence of its effect limited.
Ilofotase alfa is a human recombinant alkaline phosphatase with reno-protective effects that showed improved survival and reduced Major Adverse Kidney Events by 90 days (MAKE90) in sepsis-associated acute kidney injury (SA-AKI) patients. REVIVAL, was phase-3 trial conducted to confirm its efficacy safety. In this international double-blinded randomized-controlled trial, SA-AKI patients were enrolled < 72 h on vasopressor 24 of AKI. The primary endpoint 28-day all-cause mortality. main...
Importance Supplemental oxygen is ubiquitously used in patients with COVID-19 and severe hypoxemia, but a lower dose may be beneficial. Objective To assess the effects of targeting Pa o 2 60 mm Hg vs 90 hypoxemia intensive care unit (ICU). Design, Setting, Participants Multicenter randomized clinical trial including 726 adults receiving at least 10 L/min or mechanical ventilation 11 ICUs Europe from August 2020 to March 2023. The was prematurely stopped prior outcome assessment due slow...
Norepinephrine, the first-line vasopressor for septic shock, is not always effective and has important catecholaminergic adverse effects. Selepressin, a selective vasopressin V1a receptor agonist, noncatecholaminergic that may mitigate sepsis-induced vasodilatation, vascular leakage, edema, with fewer To test whether selepressin improves outcome in shock. An adaptive phase 2b/3 randomized clinical trial comprising 2 parts included adult patients (n = 868) shock requiring more than 5 μg/min...
Importance Red blood cell (RBC) transfusion is common among patients admitted to the intensive care unit (ICU). Despite multiple randomized clinical trials of hemoglobin (Hb) thresholds for transfusion, little known about how these are incorporated into current practice. Objective To evaluate and describe ICU RBC practices worldwide. Design, Setting, Participants International, prospective, cohort study that involved 3643 adult from 233 ICUs in 30 countries on 6 continents March 2019 October...
To assess the incidence, risk factors, and outcomes of atrial fibrillation (AF) in ICU to describe current practice management AF.Multicenter, prospective, inception cohort study.Forty-four ICUs 12 countries four geographical regions.Adult, acutely admitted patients without a history persistent/permanent AF or recent cardiac surgery were enrolled; periods from October 2020 June 2021.None.We included 1,423 analyzed 1,415 (99.4%), among whom 221 had 539 episodes AF. Most (59%) diagnosed with...
We assessed long-term outcomes in acutely admitted adult patients with delirium treated intensive care unit (ICU) haloperidol versus placebo.
To explore whether a strategy of more intensive antibiotic therapy leads to emergence or prolongation renal failure in care patients.Secondary analysis from randomised trial (the Procalcitonin And Survival Study). The arms were conserved the primary for main analysis.Nine mixed surgical/medical units across Denmark.1200 adult patients, 18+ years, expected stay +24 h.bilirubin >40 mg/dl, triglycerides >1000 increased risk blood sampling, pregnant/breast feeding and psychiatric...
Background In the early phase of pandemic, some guidelines recommended use corticosteroids for critically ill patients with COVID‐19, whereas others against despite lack firm evidence either benefit or harm. COVID STEROID trial, we aimed to assess effects low‐dose hydrocortisone on patient‐centred outcomes in adults COVID‐19 and severe hypoxia. Methods this multicentre, parallel‐group, placebo‐controlled, blinded, centrally randomised, stratified clinical randomly assigned confirmed hypoxia...
Thrombocytopenia (platelet count < 150 × 109/L) is common in intensive care unit (ICU) patients and likely associated with worse outcomes. In this study we present international contemporary data on thrombocytopenia ICU patients. We conducted a prospective cohort adult 52 ICUs across 10 countries. assessed frequencies of thrombocytopenia, use platelet transfusions clinical outcomes including mortality. evaluated pre-selected potential risk factors for the development during stay associations...